scholarly journals Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Elhanan Nahum ◽  
Avichai Weissbach ◽  
Eytan Kaplan ◽  
Gili Kadmon
Keyword(s):  
Septic Shock ◽  
Critically Ill ◽  
Inotropic Support ◽  
Critically Ill Children ◽  
Hemodynamic Effects ◽  
Intravenous Paracetamol

scholarly journals Septic shock and vasopressor requirement is associated with lower vitamin D levels in critically ill children

Critical Care ◽  
2011 ◽  
Vol 15 (S3) ◽  
Author(s):  
K Madden ◽  
HA Feldman ◽  
E Smith ◽  
CM Gordon ◽  
S Keisling ◽  
...  
Keyword(s):  
Vitamin D ◽  
Septic Shock ◽  
Critically Ill ◽  
Critically Ill Children ◽  
Vitamin D Levels ◽  
Lower Vitamin

scholarly journals The Association Between Vitamin E Deficiency and Critically Ill Children With Sepsis and Septic Shock

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongxing Dang ◽  
Jing Li ◽  
Chengjun Liu ◽  
Feng Xu
Keyword(s):  
Septic Shock ◽  
Vitamin E ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Independent Effect ◽  
Critically Ill Children ◽  
Vitamin E Deficiency ◽  
Suspected Infection ◽  
Sepsis And Septic Shock ◽  
Vitamin E Status

Background: Literature is scarce on the assessment of vitamin E status in septic children. We aim to investigate the prevalence of vitamin E deficiency in critically ill children with sepsis and septic shock and its association with clinical features and outcomes.Methods: We compared serum vitamin E status between the confirmed or suspected infection and no infection groups, the sepsis shock and no sepsis shock groups upon pediatric intensive care unit admission. Clinical characteristics were compared in subgroup patients with and without vitamin E deficiency. The association between vitamin E deficiency and septic shock were evaluated using univariate and multivariable methods.Results: 182 critically ill children with confirmed or suspected infection and 114 without infection were enrolled. The incidence of vitamin E deficiency was 30.2% in the infection group and 61.9% in the septic shock subgroup (P < 0.001). Thirty-days mortality in critically ill children with vitamin E deficiency was significantly higher than that without vitamin E deficiency (27.3 vs. 14.2%, P < 0.05). Vitamin E levels were inversely associated with higher pediatric risk of mortality (r = − 0.238, P = 0.001) and cardiovascular sequential organ failure assessment (r = −0.249, p < 0.001) scores in critically ill children with infection. In multivariable logistic regression, vitamin E deficiency showed an independent effect on septic shock (adjusted OR: 6.749, 95%CI: 2.449–18.60, P < 0.001).Conclusion: Vitamin E deficiency is highly prevalent in critically ill children with sepsis and contributed to the septic shock.

scholarly journals Effectiveness of predicting outcome in septic shock in critically ill children by assessing serum lactate levels

2016 ◽  
Vol 3 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Dr. Jasashree Choudhury ◽  
◽  
Dr. Sidharth Sraban Routray ◽  
Dr Laxmidhar Dash ◽  
◽  
...  
Keyword(s):  
Septic Shock ◽  
Critically Ill ◽  
Serum Lactate ◽  
Critically Ill Children ◽  
Predicting Outcome ◽  
Lactate Levels

Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock

1997 ◽  
Vol 25 (9) ◽  
pp. 1588-1593 ◽  
Author(s):  
Brian Krafte-Jacobs ◽  
Richard Brilli ◽  
Csaba Szabo ◽  
Alvin Denenberg ◽  
Lori Moore ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Septic Shock ◽  
Critically Ill ◽  
Critically Ill Children ◽  
Nitrate Concentrations ◽  
Nitrite Nitrate

Evaluation of Sepsis-Induced Coagulopathy in Critically Ill Pediatric Patients with Septic Shock

2020 ◽  
Author(s):  
Won Kyoung Jhang ◽  
Seong Jong Park
Keyword(s):  
Septic Shock ◽  
Prognostic Factor ◽  
Critically Ill ◽  
Pediatric Patients ◽  
Characteristic Curve ◽  
Scoring Systems ◽  
Critically Ill Children ◽  
Good Ability ◽  
Number Of Patients ◽  
Sepsis And Septic Shock

Abstract Background Coagulopathy is a common serious complication of sepsis and septic shock; thus, its early detection and prompt management are important. For this purpose, recently the sepsis-induced coagulopathy (SIC) score was proposed. Methods We modified the SIC score for critically ill children with septic shock and evaluated its performance in comparison to several coagulopathy diagnostic scoring systems. Results Among 135 included patients, a significant number of patients were diagnosed with coagulopathy using different coagulopathy diagnostic criteria (up to 84.4% using the SIC score). The modified SIC score, comprising the pediatric sequential organ failure assessment (pSOFA) score, prothrombin time, and D-dimer, was used to diagnose SIC in 68 (50.4%) patients. It was well correlated with the pSOFA score and the International Society on Thrombosis and Haemostasis disseminated intravascular coagulation (DIC) score, as well as the SIC score (p < 0.001). The overall 28-day mortality rate was 18.7%. Patients with coagulopathy had worse clinical outcomes compared to those without coagulopathy. The modified SIC score was identified as an independent prognostic factor for 28-day mortality. The area under the receiver operating characteristic curve for performance of the modified SIC score to predict 28-day mortality evaluated was 0.771 (95% confidence interval: 0.658–0.883), better than those of the SIC and ISTH DIC scores (p < 0.05). Conclusion Critically ill pediatric patients with septic shock frequently had concomitant coagulopathy. The modified SIC score showed good ability to predict 28-day mortality, suggesting its potential as a prognostic factor in these critically ill pediatric patients.

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