scholarly journals Metal complexation-mediated stable and biocompatible nanoformulation of clinically approved near-infrared absorber for improved tumor targeting and photonic theranostics

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Yong-Deok Lee ◽  
Hyeon Jeong Shin ◽  
Jounghyun Yoo ◽  
Gayoung Kim ◽  
Min-Kyoung Kang ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Metal Ion ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Serum Proteins ◽  
Metal Complexation ◽  
Infrared Laser ◽  
Pluronic F127 ◽  
Great Promise ◽  
Infrared Laser Irradiation

AbstractIndocyanine green (ICG) is a clinically approved dye that has shown great promise as a phototheranostic material with fluorescent, photoacoustic and photothermal responses in the near-infrared region. However, it has certain limitations, such as poor photostability and non-specific binding to serum proteins, subjected to rapid clearance and decreased theranostic efficacy in vivo. This study reports stable and biocompatible nanoparticles of ICG (ICG-Fe NPs) where ICG is electrostatically complexed with an endogenously abundant metal ion (Fe3+) and subsequently nanoformulated with a clinically approved polymer surfactant, Pluronic F127. Under near-infrared laser irradiation, ICG-Fe NPs were found to be more effective for photothermal temperature elevation than free ICG molecules owing to the improved photostability. In addition, ICG-Fe NPs showed the markedly enhanced tumor targeting and visualization with photoacoustic/fluorescent signaling upon intravenous injection, attributed to the stable metal complexation that prevents ICG-Fe NPs from releasing free ICG before tumor targeting. Under dual-modal imaging guidance, ICG-Fe NPs could successfully potentiate photothermal therapy of cancer by applying near-infrared laser irradiation, holding potential as a promising nanomedicine composed of all biocompatible ingredients for clinically relevant phototheranostics.

scholarly journals An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Targeting Ability

Abstract Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods:The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated.Results:The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment.Conclusion:A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.

scholarly journals An Internal Cross-Linked Polymeric Nanoparticle with Dual Sensitivity for Combination Therapy of Muscle-Invasive Bladder Cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Photothermal Effect ◽  
Bladder Cancer Cells ◽  
Infrared Laser Irradiation

Abstract Chemotherapy is an emerging effective treatment for cancer. However, one of the reasons why chemotherapy has a limited therapeutic effect in bladder cancer is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that sensitive to high concentrations of glutathione and near-infrared laser irradiation, which increases the drug accumulation at the tumor site and combines chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods: The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and photothermal effect of NPs were demonstrated. Therapeutic efficacy of NPs for bladder cancer was evaluated.Results: The DOX&IR780@PEG-PCL-SS NPs we synthesized use internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes in nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drug from the nanoparticles, producing a photothermal effect and further killing the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of drugs in tumor cells. The mice in the experimental group can be found to have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by small animal imaging and have good imaging results, to facilitate our assessment during the experiment.Conclusion: A dual sensitivity to glutathione and near-infrared laser irradiation. Long-circulating nanoparticle was developed for delivering IR780 and DOX, which could achieve NIR laser-controlled drug release and imaging guidance for chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases.

scholarly journals An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Targeting Ability

Abstract Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods:The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated.Results:The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment.Conclusion:A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.

Near infrared laser irradiation induces NETosis via oxidative stress and autophagy

2018 ◽  
Vol 33 (9) ◽  
pp. 1919-1924 ◽  
Author(s):  
Mario Migliario ◽  
Stelvio Tonello ◽  
Vincenzo Rocchetti ◽  
Manuela Rizzi ◽  
Filippo Renò
Keyword(s):  
Oxidative Stress ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation

Facile synthesis of monodisperse chromogenic amylose–iodine nanoparticles as an efficient broad-spectrum antibacterial agent

2020 ◽  
Vol 8 (15) ◽  
pp. 3010-3015
Author(s):  
Yanbin Sun ◽  
Xianwen Wang ◽  
Linxin Fan ◽  
Xianli Xie ◽  
Zhaohua Miao ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Near Infrared ◽  
Infrared Laser ◽  
Facile Synthesis ◽  
Infrared Laser Irradiation

Monodisperse chromogenic amylose–iodine nanoparticles were developed as an efficient broad-spectrum antibacterial agent under the assistance of near-infrared laser irradiation.

Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation

2010 ◽  
Vol 42 (6) ◽  
pp. 566-576 ◽  
Author(s):  
Yoichi Uozumi ◽  
Hiroshi Nawashiro ◽  
Shunichi Sato ◽  
Satoko Kawauchi ◽  
Katsuji Shima ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation

Thermal effects of transcranial near-infrared laser irradiation on rabbit cortex

2013 ◽  
Vol 553 ◽  
pp. 99-103 ◽  
Author(s):  
Yongmei Chen ◽  
Luis De Taboada ◽  
Michael O’Connor ◽  
Scott Delapp ◽  
Justin A. Zivin
Keyword(s):  
Laser Irradiation ◽  
Thermal Effects ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation
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