scholarly journals Generation, repair and replication of guanine oxidation products

2017 ◽  
Vol 39 (1) ◽  
Author(s):  
Katsuhito Kino ◽  
Masayo Hirao-Suzuki ◽  
Masayuki Morikawa ◽  
Akane Sakaga ◽  
Hiroshi Miyazawa
Keyword(s):  
Oxidation Products ◽  
Guanine Oxidation

scholarly journals Mapping three guanine oxidation products along DNA following exposure to three types of reactive oxygen species

2018 ◽  
Vol 121 ◽  
pp. 180-189 ◽  
Author(s):  
Brock Matter ◽  
Christopher L. Seiler ◽  
Kristopher Murphy ◽  
Xun Ming ◽  
Jianwei Zhao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxidation Products ◽  
Oxygen Species ◽  
Guanine Oxidation

scholarly journals In Vivo Bypass Efficiencies and Mutational Signatures of the Guanine Oxidation Products 2-Aminoimidazolone and 5-Guanidino-4-nitroimidazole

2004 ◽  
Vol 279 (42) ◽  
pp. 43568-43573 ◽  
Author(s):  
William L. Neeley ◽  
James C. Delaney ◽  
Paul T. Henderson ◽  
John M. Essigmann
Keyword(s):  
Oxidation Products ◽  
Mutational Signatures ◽  
Guanine Oxidation

scholarly journals Rates of Chemical Cleavage of DNA and RNA Oligomers Containing Guanine Oxidation Products

2015 ◽  
Vol 28 (6) ◽  
pp. 1292-1300 ◽  
Author(s):  
Aaron M. Fleming ◽  
Omar Alshykhly ◽  
Judy Zhu ◽  
James G. Muller ◽  
Cynthia J. Burrows
Keyword(s):  
Oxidation Products ◽  
Guanine Oxidation ◽  
Chemical Cleavage ◽  
Dna And Rna ◽  
Rna Oligomers

scholarly journals Analysis of Guanine Oxidation Products in Double-Stranded DNA and Proposed Guanine Oxidation Pathways in Single-Stranded, Double-Stranded or Quadruplex DNA

Biomolecules ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 140-159 ◽  
Author(s):  
Masayuki Morikawa ◽  
Katsuhito Kino ◽  
Takanori Oyoshi ◽  
Masayo Suzuki ◽  
Takanobu Kobayashi ◽  
...  
Keyword(s):  
Oxidation Products ◽  
Guanine Oxidation ◽  
Quadruplex Dna ◽  
Double Stranded Dna

scholarly journals Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO5: At Least Three Independent Reaction Pathways

2001 ◽  
Vol 8 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Andrea Lapi ◽  
Geneviève Pratviel ◽  
Bernard Meunier
Keyword(s):  
Degradation Products ◽  
Oxidation Products ◽  
Spiro Compound ◽  
Reaction Pathways ◽  
Guanine Oxidation ◽  
Double Stranded Dna ◽  
Independent Reaction ◽  
Reaction Routes ◽  
Damaged Dna

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO5 on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.

scholarly journals On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

2020 ◽  
Vol 49 (18) ◽  
pp. 6524-6528 ◽  
Author(s):  
Aaron M. Fleming ◽  
Cynthia J. Burrows
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Hydroxyl Radical ◽  
Radical Anion ◽  
Oxidation Products ◽  
Oxygen Species ◽  
Carbonate Radical ◽  
Guanine Oxidation ◽  
Carbonate Radical Anion

Carbonate radical anion, not hydroxyl radical, is the principal reactive oxygen species generated from endogenous oxidative stress endowing epigenetic features to guanine oxidation products in DNA.

Sign in / Sign up

Export Citation Format

Share Document