scholarly journals Analysis of Guanine Oxidation Products in Double-Stranded DNA and Proposed Guanine Oxidation Pathways in Single-Stranded, Double-Stranded or Quadruplex DNA

Biomolecules ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 140-159 ◽  
Author(s):  
Masayuki Morikawa ◽  
Katsuhito Kino ◽  
Takanori Oyoshi ◽  
Masayo Suzuki ◽  
Takanobu Kobayashi ◽  
...  
Keyword(s):  
Oxidation Products ◽  
Guanine Oxidation ◽  
Quadruplex Dna ◽  
Double Stranded Dna

scholarly journals Guanine Oxidation in Double-stranded DNA by MnTMPyP/KHSO5: At Least Three Independent Reaction Pathways

2001 ◽  
Vol 8 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Andrea Lapi ◽  
Geneviève Pratviel ◽  
Bernard Meunier
Keyword(s):  
Degradation Products ◽  
Oxidation Products ◽  
Spiro Compound ◽  
Reaction Pathways ◽  
Guanine Oxidation ◽  
Double Stranded Dna ◽  
Independent Reaction ◽  
Reaction Routes ◽  
Damaged Dna

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to KHSO5 on oligonucleotides. We found that the three major products of guanine oxidation are formed by independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.

scholarly journals Targeted Guanine Oxidation by a Dinuclear Copper(II) Complex at Single-Stranded/Double-Stranded DNA Junctions.

2006 ◽  
Vol 45 (22) ◽  
pp. 9145-9145
Author(s):  
Lei Li ◽  
Narasimha N. Murthy ◽  
Joshua Telser ◽  
Lev N. Zakharov ◽  
Glenn P. A. Yap ◽  
...  
Keyword(s):  
Guanine Oxidation ◽  
Dinuclear Copper ◽  
Double Stranded Dna ◽  
Dna Junctions

scholarly journals Generation, repair and replication of guanine oxidation products

2017 ◽  
Vol 39 (1) ◽  
Author(s):  
Katsuhito Kino ◽  
Masayo Hirao-Suzuki ◽  
Masayuki Morikawa ◽  
Akane Sakaga ◽  
Hiroshi Miyazawa
Keyword(s):  
Oxidation Products ◽  
Guanine Oxidation

scholarly journals Mapping three guanine oxidation products along DNA following exposure to three types of reactive oxygen species

2018 ◽  
Vol 121 ◽  
pp. 180-189 ◽  
Author(s):  
Brock Matter ◽  
Christopher L. Seiler ◽  
Kristopher Murphy ◽  
Xun Ming ◽  
Jianwei Zhao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxidation Products ◽  
Oxygen Species ◽  
Guanine Oxidation

scholarly journals In Vivo Bypass Efficiencies and Mutational Signatures of the Guanine Oxidation Products 2-Aminoimidazolone and 5-Guanidino-4-nitroimidazole

2004 ◽  
Vol 279 (42) ◽  
pp. 43568-43573 ◽  
Author(s):  
William L. Neeley ◽  
James C. Delaney ◽  
Paul T. Henderson ◽  
John M. Essigmann
Keyword(s):  
Oxidation Products ◽  
Mutational Signatures ◽  
Guanine Oxidation

scholarly journals Exploring the preferential interaction of quercetin with VEGF promoter G-quadruplex DNA and construction of a pH-dependent DNA-based logic gate

RSC Advances ◽  
2017 ◽  
Vol 7 (59) ◽  
pp. 37230-37240 ◽  
Author(s):  
Snehasish Bhattacharjee ◽  
Pradeep K. Sengupta ◽  
Sudipta Bhowmik
Keyword(s):  
Logic Gate ◽  
Quadruplex Dna ◽  
Preferential Interaction ◽  
Double Stranded Dna ◽  
G4 Dna ◽  
G Quadruplex ◽  
Flavonoid Quercetin ◽  
Ph Dependent

The plant flavonoid quercetin (Que) binds more efficiently to VEGF G-quadruplex DNA (G4–DNA) compared to double stranded DNA as well as other G4–DNAs.

scholarly journals 9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene: Synthesis and G-quadruplex Selectivity

Molbank ◽  
10.3390/m1138 ◽  
2020 ◽  
Vol 2020 (2) ◽  
pp. M1138
Author(s):  
Giovanni Ribaudo ◽  
Alberto Ongaro ◽  
Erika Oselladore ◽  
Giuseppe Zagotto ◽  
Maurizio Memo ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Binding Mode ◽  
Sonogashira Reaction ◽  
Ionization Mass ◽  
Quadruplex Dna ◽  
Anthracene Derivative ◽  
Double Stranded Dna ◽  
G Quadruplex ◽  
A3 Coupling ◽  
Hydroxyethyl Piperazine

G-quadruplex DNA is the target of several natural and synthetic small molecules with antiproliferative and antiviral activity. We here report the synthesis through Sonogashira reaction and A3 coupling of a disubstituted anthracene derivative, 9,10-bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene. The binding of this compound to G-quadruplex and double stranded DNA sequences was evaluated using electrospray ionization mass spectrometry (ESI-MS), demonstrating selectivity for the first structure. The interaction pattern of the ligand with G-quadruplex was investigated by molecular docking and stacking was found to be the preferred binding mode.

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