Efficacy of prebiotics in promoting a healthy gut microbiota in adults and elderly persons in the community

Nutrire ◽  
2021 ◽  
Vol 46 (2) ◽  
Author(s):  
Jéssica Tatiane Sena da Silva ◽  
Carina Lumie Pereira Nagata
Keyword(s):  
Gut Microbiota ◽  
Elderly Persons

scholarly journals Influence of galacto-oligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabonomics in elderly persons

2015 ◽  
Vol 114 (4) ◽  
pp. 586-595 ◽  
Author(s):  
Jelena Vulevic ◽  
Aleksandra Juric ◽  
Gemma E. Walton ◽  
Sandrine P. Claus ◽  
George Tzortzis ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Immune Function ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Elderly Persons ◽  
Elderly Age ◽  
Double Blind ◽  
Bacterial Populations ◽  
Age Related

It is recognised that ageing induces various changes to the human colonic microbiota. Most relevant is a reduction in bifidobacteria, which is a health-positive genus. Prebiotics, such as galacto-oligosaccharides (GOS), are dietary ingredients that selectively fortify beneficial gut microbial groups. Therefore, they have the potential to reverse the age-related decline in bifidobacteria and modulate associated health parameters. We assessed the effect of GOS mixture (Bimuno (B-GOS)) on gut microbiota, markers of immune function and metabolites in forty elderly (age 65–80 years) volunteers in a randomised, double-blind, placebo (maltodextrin)-controlled, cross-over study. The intervention periods consisted of 10 weeks with daily doses of 5·5 g/d with a 4-week washout period in between. Blood and faecal samples were collected for the analyses of faecal bacterial populations and immune and metabolic biomarkers. B-GOS consumption led to significant increases in bacteroides and bifidobacteria, the latter correlating with increased lactic acid in faecal waters. Higher IL-10, IL-8, natural killer cell activity and C-reactive protein and lower IL-1β were also observed. Administration of B-GOS to elderly volunteers may be useful in positively affecting the microbiota and some markers of immune function associated with ageing.

scholarly journals Insights into the gut microbiota of Nigerian elderly with type 2 diabetes and non-diabetic elderly persons

Heliyon ◽  
2020 ◽  
Vol 6 (5) ◽  
pp. e03971 ◽  
Author(s):  
A.O. Afolayan ◽  
L.A. Adebusoye ◽  
E.O. Cadmus ◽  
F.A. Ayeni
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Elderly Persons

Differences in the gut microbiota between young and elderly persons in Korea

2021 ◽  
Vol 87 ◽  
pp. 31-40 ◽  
Author(s):  
Seung Yun Lee ◽  
Da Young Lee ◽  
Hea Jin Kang ◽  
Ji Hyeop Kang ◽  
Min Gi Cho ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Elderly Persons

scholarly journals Effect of prebiotics on the human gut microbiota of elderly persons

Gut Microbes ◽  
2012 ◽  
Vol 3 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Ruth Toward ◽  
Samantha Montandon ◽  
Gemma Walton ◽  
Glenn R. Gibson
Keyword(s):  
Gut Microbiota ◽  
Elderly Persons ◽  
Human Gut ◽  
Human Gut Microbiota

Folate and vitamin B-12 deficiencies additively impaired memory function and disturbed the gut microbiota in amyloid-β infused rats

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Sunmin Park ◽  
Sunna Kang ◽  
Da Sol Kim
Keyword(s):  
Insulin Resistance ◽  
Gut Microbiota ◽  
Insulin Signaling ◽  
Gut Microbiome ◽  
Metabolic Diseases ◽  
Memory Function ◽  
Amyloid Β ◽  
Impaired Memory ◽  
Ca1 Region ◽  
Folate And Vitamin B12

Abstract. Folate and vitamin B12(V-B12) deficiencies are associated with metabolic diseases that may impair memory function. We hypothesized that folate and V-B12 may differently alter mild cognitive impairment, glucose metabolism, and inflammation by modulating the gut microbiome in rats with Alzheimer’s disease (AD)-like dementia. The hypothesis was examined in hippocampal amyloid-β infused rats, and its mechanism was explored. Rats that received an amyloid-β(25–35) infusion into the CA1 region of the hippocampus were fed either control(2.5 mg folate plus 25 μg V-B12/kg diet; AD-CON, n = 10), no folate(0 folate plus 25 μg V-B12/kg diet; AD-FA, n = 10), no V-B12(2.5 mg folate plus 0 μg V-B12/kg diet; AD-V-B12, n = 10), or no folate plus no V-B12(0 mg folate plus 0 μg V-B12/kg diet; AD-FAB12, n = 10) in high-fat diets for 8 weeks. AD-FA and AD-VB12 exacerbated bone mineral loss in the lumbar spine and femur whereas AD-FA lowered lean body mass in the hip compared to AD-CON(P < 0.05). Only AD-FAB12 exacerbated memory impairment by 1.3 and 1.4 folds, respectively, as measured by passive avoidance and water maze tests, compared to AD-CON(P < 0.01). Hippocampal insulin signaling and neuroinflammation were attenuated in AD-CON compared to Non-AD-CON. AD-FAB12 impaired the signaling (pAkt→pGSK-3β) and serum TNF-α and IL-1β levels the most among all groups. AD-CON decreased glucose tolerance by increasing insulin resistance compared to Non-AD-CON. AD-VB12 and AD-FAB12 increased insulin resistance by 1.2 and 1.3 folds, respectively, compared to the AD-CON. AD-CON and Non-AD-CON had a separate communities of gut microbiota. The relative counts of Bacteroidia were lower and those of Clostridia were higher in AD-CON than Non-AD-CON. AD-FA, but not V-B12, separated the gut microbiome community compared to AD-CON and AD-VB12(P = 0.009). In conclusion, folate and B-12 deficiencies impaired memory function by impairing hippocampal insulin signaling and gut microbiota in AD rats.

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