Diabetic peripheral neuropathy: the potential role of vitamin D deficiency

Background: The exact pathogenic mechanism of the painful diabetic peripheral neuropathy (DPN) is poorly understood. Our study aimed to evaluate the association amongst vitamin D status, inflammatory cytokines, and painful DPN.Methods: A total of 483 patients were divided into three groups, i.e., diabetes without DPN (no-DPN, n = 86), diabetes with painless DPN (painless DPN, n = 176) and diabetes with painful DPN (painful DPN, n = 221) groups. Basic information and laboratory results were collected. The concentrations of vitamin D (25-hydroxyvitamin D), high-sensitivity C-reactive protein, interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were also measured.Results: The prevalence of severe vitamin D deficiency (<10 ng/mL) was more common in the painful DPN group than in the painless DPN and no-DPN groups (25.8,12.5, and 8.1%, respectively, P < 0.01). Cases in the painful DPN group had significantly higher concentrations of IL-6 (P < 0.01) and TNF-α (P < 0.01) than those in the two other groups. The multivariate logistic analysis showed that severe vitamin D deficiency, IL-6, and TNF-α were independent risks for painful DPN after adjusting for confounding factors. Furthermore, the vitamin D status had significantly negative correlations with IL-6 (r = −0.56, P < 0.01) and TNF-α (r = −0.47, P < 0.01) levels.Conclusion: Severe vitamin D deficiency was an independent risk factor for the painful DPN. Severe vitamin D deficiency status may play a role in the painful DPN pathogenesis through elevated IL-6 and TNF-α levels.

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Letter: sleep and psychological disorders in patients with inflammatory bowel diseases; another potential role of vitamin D deficiency

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.12614 ◽

2014 ◽

Vol 39 (5) ◽

pp. 548-548

Author(s):

A. Gholamrezaei ◽

M. H. Emami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Bowel Diseases ◽

Potential Role ◽

Psychological Disorders ◽

Bowel Diseases ◽

Inflammatory Bowel

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Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic

QJM ◽

10.1093/qjmed/hcaa234 ◽

2020 ◽

Cited By ~ 1

Author(s):

M Verdoia ◽

G De Luca

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Broad Spectrum ◽

Potential Role ◽

Hypovitaminosis D ◽

Mechanisms Of Action ◽

Vitamin D Supplementation ◽

Current Status ◽

Special Focus

Summary Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide and displaying a broad spectrum of implications on cardiovascular and inflammatory disorders. Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-CoV-2 infection. We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic.

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Potential role of vitamin D deficiency on Fabry cardiomyopathy

Journal of Inherited Metabolic Disease ◽

10.1007/s10545-013-9653-8 ◽

2013 ◽

Vol 37 (2) ◽

pp. 289-295 ◽

Cited By ~ 4

Author(s):

Christiane Drechsler ◽

Benjamin Schmiedeke ◽

Markus Niemann ◽

Daniel Schmiedeke ◽

Johannes Krämer ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Potential Role

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Vitamin D Deficiency in Patients with Diabetic Peripheral Neuropathy

Journal of Islamabad Medical & Dental College ◽

10.35787/jimdc.v7i4.266 ◽

2019 ◽

Vol 7 (4) ◽

pp. 291-294

Author(s):

Hameedullah Khan ◽

Ihsanullah Rajar ◽

Abdul Rauf Memon ◽

Nadeem Naeem

Keyword(s):

Vitamin D ◽

Peripheral Neuropathy ◽

Diabetic Neuropathy ◽

Vitamin D Deficiency ◽

Diabetic Peripheral Neuropathy ◽

Cross Sectional Study ◽

Key Words Diabetes ◽

Cross Sectional ◽

Peripheral Diabetic Neuropathy ◽

Diabetes Peripheral Neuropathy

Objective: To determine the frequency of vitamin D deficiency in patients presenting with diabetic peripheral neuropathyPatients and Methods: This cross sectional study was carried out in Department of Medicine and Neurology Indus Medical College, Tando Muhammad khan. from March 2017 to August 2017. Total 74 cases of Diabetes Mellitus presenting with peripheral diabetic neuropathy were selected for the study. Evolution of degree of Neuropathy was based on TCSS score as: {no neuropathy: ≤5, severe: ≥12, moderate: 9-11 and mild: 6-8}. Vitamin D level was categorized as (deficiency (0-20 ng/ml), insufficiency (21-30 ng/ml) sufficiency (>30 ng/ml), excess (>50 ng/ml) and toxicity (>100 ng/ml). All the data was entered in SPSS.Results: Total 74 patients with diabetic neuropathy were studied. Vast majority of patients 36(48.6%) were found in age group 51-60 years, Majority were males 45(60.8%). Most of the cases 35(47.3%) were with 1-3 years duration of neuropathy. Majority of patients 42(56.8%) were found with Mild peripheral neuropathy. Vitamin-D deficiency was present in 2(43.2%) cases and insufficiency was observed in 27(36.5%) cases. No significant association was found between vitamin D deficiency and severity of neuropathy.Conclusion: Vitamin D deficiency was found (43.2%) in patients of diabetic peripheral neuropathy. Vitamin screening and intake of supplement is necessary, will help to decrease the complication of peripheral neuropathy in Diabetic cases. Key words: Diabetes, Peripheral neuropathy, Vitamin D

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