High-dose Vitamin D supplementation reduces inflammation and improves microcirculation in patients with diabetic peripheral neuropathy – a randomized control trial

2020 ◽  
Author(s):  
Anna Stepanova ◽  
Tatiana Karonova ◽  
Anna Bystrova ◽  
Edward Jude
Keyword(s):  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Randomized Control Trial ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Randomized Control ◽  
High Dose Vitamin

scholarly journals Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Mary A. Byrn ◽  
William Adams ◽  
Sue Penckofer ◽  
Mary Ann Emanuele
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cognitive Function ◽  
Randomized Control Trial ◽  
Low Dose ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Significant Finding ◽  
Randomized Control

Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months. The primary outcome was a battery of neuropsychological tests. Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Repeated assessments of cognitive measures were collected over 12 weeks using alternative testing forms to minimize practice effects. Results. Thirty participants were randomized to either the low-dose allocation (n=15) or the high-dose allocation (n=15). Most participants were female (83%) and identified as Black (57%). For all cognition measures, there was no statistically significant finding between participants who received high-dose vitamin D supplementation and those who received low-dose supplementation. However, when assessing cognitive function in both groups over time, minimal improvement on the Symbol-Digits, the Stroop Interference Test, and the Trail Making Test Part B was observed. Conclusions. To our knowledge, this is the first randomized control trial to examine the effects of vitamin D supplementation on cognitive function in people with type 2 diabetes. However, no significant differences in cognitive outcomes between participants who received high-dose therapy and those who received low dose were found.

scholarly journals Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1280
Author(s):  
Jan Mieszkowski ◽  
Andżelika Borkowska ◽  
Błażej Stankiewicz ◽  
Andrzej Kochanowicz ◽  
Bartłomiej Niespodziński ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inflammatory Marker ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Oncostatin M ◽  
Control Group ◽  
High Dose ◽  
Double Blind ◽  
Single High Dose ◽  
High Dose Vitamin

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.

scholarly journals Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial

2019 ◽  
Vol 109 (6) ◽  
pp. 1578-1587 ◽  
Author(s):  
Zarintaj Malihi ◽  
Carlene M M Lawes ◽  
Zhenqiang Wu ◽  
Ying Huang ◽  
Debbie Waayer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Serum Calcium ◽  
Kidney Stone ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Randomized Controlled ◽  
High Dose Vitamin

scholarly journals High Dose Vitamin D Supplementation Is Associated With a Reduction in Depression Score Among Adolescent Girls: A Nine-Week Follow-Up Study

2017 ◽  
Vol 15 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Afsane Bahrami ◽  
Seyed Reza Mazloum ◽  
Shahrokh Maghsoudi ◽  
Davood Soleimani ◽  
Sayyed Saeid Khayyatzadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adolescent Girls ◽  
Vitamin D Supplementation ◽  
Depression Score ◽  
High Dose ◽  
Follow Up Study ◽  
High Dose Vitamin

scholarly journals Monthly High-Dose Vitamin D Supplementation and Cancer Risk

JAMA Oncology ◽  
2018 ◽  
Vol 4 (11) ◽  
pp. e182178 ◽  
Author(s):  
Robert Scragg ◽  
Kay-Tee Khaw ◽  
Les Toop ◽  
John Sluyter ◽  
Carlene M. M. Lawes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
High Dose Vitamin
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