Lower genital tract infections in young female juvenile idiopathic arthritis patients

Abstract Background To evaluate human papillomavirus (HPV), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in juvenile idiopathic arthritis (JIA) patients. Methods After exclusion, 33 female adolescent and young JIA patients (ILAR criteria) and 28 healthy controls were selected for this study. Demographic data, gynecological, sexual function, cervical cytology and histological abnormalities were evaluated. JIA clinical/laboratorial parameters and treatment were also assessed. HPV-DNA, CT-DNA and NG-DNA testing in cervical specimens were performed by Hybrid Capture 2 assays. Results The mean current age was similar in JIA patients and controls (23.3 ± 6.24 vs. 26.1 ± 6.03 years, p = 0.09). The frequencies of sexual intercourse (76% vs. 89%, p = 0.201) and abnormal cervical cytology (24% vs. 11%, p = 0.201) were similar in JIA compared to controls. The higher frequency of HPV infection in JIA patients than controls (30% vs. 11%, p = 0.155) did not reach statistical significance. CT (0% vs. 7%, p = 0.207) and NG infections (0% vs. 4%, p = 0.459) were also alike in both groups. Further evaluation of JIA patients with abnormal and normal cervical cytology showed that the former group had a higher frequency of HPV infection (87% vs. 12%, p = 0.0002) with a low frequency of HPV vaccination (0% vs. 8%, p = 1.0). No differences were evidenced between these two JIA groups regarding demographic data, sexual function and clinical/laboratorial parameters. The frequencies of methotrexate (p = 0.206) and biological agent use (p = 0.238) were similar in both JIA groups. Conclusions To our knowledge, this was the first study to assess lower genital infections in JIA patients allowing the identification of HPV as main cause of cervical dysplasia. Methotrexate and biological agents do not seem to increase risk of lower genital tract infections in JIA patients.

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SCREENING OF INFERTILE FEMALES FOR LOWER GENITAL TRACT INFECTIONS

International Journal of Advanced Research ◽

10.21474/ijar01/13942 ◽

2021 ◽

Vol 9 (12) ◽

pp. 553-558

Author(s):

Ankana Chakraborty B.A. Dalal ◽

◽

S.M. Bhatawadekar ◽

C.S. Deshmukh ◽

K.K. Lahiri ◽

...

Keyword(s):

Tract Infection ◽

Genital Tract ◽

Clinical Symptoms ◽

Demographic Data ◽

Female Reproductive Tract ◽

Isolation And Identification ◽

Reproductive Tract Infection ◽

Lower Genital Tract ◽

Genital Tract Infections ◽

Tract Infections

Introduction: Infertility has been known to cause serious social and emotional problems worldwide. Besides other causes of female infertility, the role of female reproductive tract infection is well recognized. Lower genital tract infection, be it symptomatic or asymptomatic, need to be diagnosed and treated properly. In view of this our study was done. Aim & Objectives: To evaluate the bacteriological profile of lower genital tract in infertile females. Methodology: It was a cross sectional type of study. After taking consent, three swabs (high vaginal swab, endocervical swab and swab from lateral vaginal wall) were taken from 100 infertile women. A questionnaire covering demographic data, menstrual history, medical history, history of infertility, etc. was completed for each of the participants. Isolation and identification of the isolates were done as per conventional techniques. Antibiotic Susceptibility Testing was done for the aerobic isolates as per CLSI guidelines. Results: In our study, 47% of females were asymptomatic and majority them showed positive microbiological growth. E.coli and S.aureus were the most common aerobic isolates and Prevotella spp. was the most common anaerobic isolate. Majority of the anaerobes were associated with bacterial vaginosis. Majority of our isolates were susceptible to Gentamicin. Conclusion: The absence of clinical symptoms does not rule out the possibility of an ongoing acute inflammatory state due infective agents. Hence, both asymptomatic and symptomatic females should be screened for lower genital tract infections as the consequences may lead to infertility.

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RESULTS OF LOWER GENITAL TRACT INFECTION INTERVENTION AMONG KHMER WOMEN OF CHILDBEARING AGE IN CAN THO IN 2016

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2018.2.14 ◽

2018 ◽

pp. 83-89

Author(s):

Trung Thuan Phan ◽

Dinh Binh Tran ◽

Thanh Hue Dinh ◽

Phong Son Dinh ◽

Kieu Oanh Truong ◽

...

Keyword(s):

Genital Tract ◽

Common Knowledge ◽

Intervention Group ◽

Effective Intervention ◽

Control Group ◽

Childbearing Age ◽

Lower Genital Tract ◽

Genital Tract Infections ◽

Tract Infections ◽

Can Tho City

Objectives: To find a model that is effective intervention to reduce the incidence of lower genital tract infections in Khmer women. Subjects and Methods: The intervention study is carried which compared the test group with the control group of 400 Khmer women, aged 15 to 49 in Can Tho city. Results: The common knowledge of the prevention of lower genital tract infections in the intervention group increased from 30.9% in the control group to 54.5% in the intervention group. The general attitude toward the use of lower genital tract infections increased from 22.3% in the control group to 78.0% in the intervention group. This is a very significant improvement. The prevalence of subclinical infection of the intervention group (26.0%) was significantly lower than that of the control group (39.3%), the difference was statistically significant. Conclusion: Intervention effectiveness is good in both knowledge, attitudes and practices, especially the effectiveness of interventions in practice in Khmer women. Key words: Effective intervention, lower genital tract infections, Khmer women, Can Tho city

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