scholarly journals The fertility assessment of normal cyclic Wistar rats following the administration of methanolic extract of Portulaca oleracea: an experimental study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Izuchukwu Azuka Okafor ◽  
Uchenna Somtochukwu Nnamah ◽  
Jude Nnaka
Keyword(s):  
Estrous Cycle ◽  
Adult Female ◽  
Wistar Rats ◽  
Major Effect ◽  
Reproductive Hormones ◽  
Portulaca Oleracea ◽  
High Dose ◽  
Methanolic Extracts ◽  
Cycle Arrest ◽  
Female Wistar Rats

Abstract Background Purslane is a widely distributed shrub used for the treatment of different ailments. The increasing reproductive complications associated with herbal treatments have led to the need to critically evaluate the safety and/or reproductive potentials of commonly used plant extracts. This study investigated the reproductive effect of methanolic extracts of Portulaca oleracea (MEPO) in adult female Wistar rats. Results Group C showed a significant decrease both in relative ovarian weight (p = 0.000), and relative uterine weight (p = 0.037), when compared with the control. There were no significant (p ˃ 0.05) changes in the levels of follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol. When compared to the control, groups B and C showed abnormal estrous cycle and cycle arrest especially at the metestrus phase with mild congestion of a few blood vessels in the ovary and uterus. Conclusions MEPO may possess some anti-fertility effect, as it disrupts the estrous cycle of adult female Wistar rats; although it has no major effect on the reproductive hormones, uterus, and ovarian histology of adult female Wistar rats. However, high dose consumption should be taken with precaution.

scholarly journals Locomotor sensitization to cocaine in adolescent and adult female Wistar rats

2018 ◽  
Vol 349 ◽  
pp. 158-162 ◽  
Author(s):  
Sydney A. Rowson ◽  
Stephanie L. Foster ◽  
David Weinshenker ◽  
Gretchen N. Neigh
Keyword(s):  
Adult Female ◽  
Wistar Rats ◽  
Locomotor Sensitization ◽  
Female Wistar Rats

Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats

2021 ◽  
Author(s):  
Suellen Ribeiro da Silva Scarton ◽  
Felipe Tsuzuki ◽  
Marina Trevizan Guerra ◽  
Dayane Priscila dos Santos ◽  
Aldair Casagrande dos Santos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
Wistar Rats ◽  
Reproductive Parameters ◽  
Female Wistar Rats

Effects of chia (Salvia hispanica L.) on oxidative stress and inflammation in ovariectomized adult female Wistar rats

2019 ◽  
Vol 10 (7) ◽  
pp. 4036-4045 ◽  
Author(s):  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Marcella Duarte Villas Mishima ◽  
Maria Eliza de Castro Moreira ◽  
Christiane Mileib Vasconcelos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Lipid Profiles ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Female Wistar Rats ◽  
Salvia Hispanica L

The study investigated the influence of chia consumption on inflammation, oxidative stress, and lipid profiles in female ovariectomized rats fed a high-fat diet.

scholarly journals Hormones of Pituitary-Gonadal Axis and Histology of Pituitary Gland Following Oral Treatment of Male Wistar Rats with Glyphosate

2018 ◽  
Vol 1 (2) ◽  
pp. 164-169
Author(s):  
S O Popoola ◽  
C L Sakpa
Keyword(s):  
Pituitary Gland ◽  
Wistar Rats ◽  
Imaging Techniques ◽  
Oral Treatment ◽  
Reproductive Hormones ◽  
High Dose ◽  
Male Adult ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
Group B

There are numerous endocrine disrupting chemicals across the globe among which is the contentious organophosphate called glyphosate. The aim was to analyze the effects of glyphosate on Wistar rat’s pituitary gland and pituitary-gonadal axis. Specific objectives determined male reproductive hormones of Wistar rats exposed to glyphosate; demonstrated possible endocrine disruptive action of glyphosate on Wistar rats and determined effects of glyphosate on histology of pituitary gland. Fifteen male adult Wistar rats of 200g and above used for the study were randomly assigned into three groups A, B and C of 5 rats in each. Group A (control) gavaged with only distilled water. Group B (low dose) and Group C (high dose) were gavaged with 400mg and 2000mg of glyphosate/kg body weight/day respectively. All the rats were treated for 60 days before sacrificing, collection of blood sample and harvesting of tissue for analysis. Collated data were entered into Statistical Package for Social Scientists (version 21) for t-test and test of significance (p<0.05).  Both follicle stimulating hormone and testosterone were significantly decreased in treated rats. The levels of luteinizing hormone, prolactin, oestrogen, progesterone and testosterone/oestrogen ratio statistically increased among treated groups. Adenohypophysis in Group B rats illustrated cellular hyperplasia with mitotic bodies while those of Group C demonstrated fewer cells that are widely separated by connective tissue. This study established glyphosate as an endocrine disrupting chemical. Histological slides of the pituitary gland of treated rats showed some level of abnormality. High-resolute imaging techniques were suggested for better imaging.

scholarly journals Combination of nanosomal form of doxorubicin, interferon alpha, and nitroglycerin in the threatment of 101.8 glioblastoma in Wistar rats

2022 ◽  
Vol 66 (9-10) ◽  
pp. 17-23
Author(s):  
V. V. Kudelkina ◽  
A. S. Khalansky ◽  
A. I. Alekseeva ◽  
P. L. Gorelikov ◽  
A. M. Kosyreva
Keyword(s):  
Wistar Rats ◽  
Combined Therapy ◽  
High Dose ◽  
No Donor ◽  
Female Wistar Rats ◽  
Median Lifespan ◽  
C6 Cell Line ◽  
Rat C6 Glioma

The search for effective approaches to the treatment of patients with glioblastoma is one of the difficult tasks of neurooncology; standard methods of therapy show limited results. Combined therapy, which includes different antitumor mechanisms, can increase its effectiveness. The combination of PLGA nanoform of doxorubicin (Dox-PLGA), antitumor cytokine — interferon alfa (IFN-α), and nitrogen oxide (NO) donor nitroglycerin (NG) was investigated in this work both in vitro (rat C6 glioma) and in vivo (rat 101.8 glioblastoma). MTT assay in the C6 cell line showed great cytotoxicity and antiproliferative effect of the combination of IFN-α with Dox-PLGA and NG. The lowest tumour cell survival was observed when using a high dose of IFN-α (10 ng/ml) in mono-mode. In the in vivo experiment, 32 female Wistar rats with 101.8 glioblastoma received therapy in the following modes: Dox-PLGA + NG; Dox-PLGA + IFN-α; Dox- PLGA + IFN-α + NG. There was a significant increase in median survival and life expectancy (ILE) in all groups receiving therapy compared to the group that did not undergo treatment. The longest median lifespan (27 days), survival up to 100 days (1 animal), ILE (131%) were observed in animals that received the combination Dox-PLGA + IFN-α+ NG, compared to the group without treatment, in which the median lifespan was 15 days. Thus, the therapy of experimental glioblastoma both in vivo and in vitro with the combination of Dox-PLGA + IFN-α + NG has the most pronounced therapeutic and antitumor effect, which must be taken into account when developing new more effective methods of treating human glioblastomas.

scholarly journals Xylopia aethiopica ethanol seed extract suppresses Cadmium chloride-induced ovary and gonadotropins toxicity in adult female Wistar rats

2021 ◽  
Vol 25 (2) ◽  
Author(s):  
Elvis.T Godam ◽  
Olugbemi Olaniyan ◽  
Chiwendu D Wofuru ◽  
Clinton D Orupabo ◽  
Kenneth S Ordu ◽  
...  
Keyword(s):  
Adult Female ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Seed Extract ◽  
Female Wistar Rats ◽  
Xylopia Aethiopica
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