scholarly journals Lung perfusion findings on perfusion SPECT/CT imaging in non-hospitalized de-isolated patients diagnosed with mild COVID-19 infection

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Osayande Evbuomwan ◽  
Gerrit Engelbrecht ◽  
Melissa V. Bergman ◽  
Sello Mokwena ◽  
Oluwatosin A. Ayeni
Keyword(s):  
Pulmonary Embolism ◽  
Lung Perfusion ◽  
Ct Imaging ◽  
Hospitalized Patients ◽  
Common Finding ◽  
Medicine Department ◽  
Nuclear Medicine Department ◽  
Mild Disease ◽  
Perfusion Spect ◽  
Perfusion Defects

Abstract Background The aim of this retrospective study is to assess the incidence and type of lung perfusion abnormalities in non-hospitalized patients diagnosed with mild COVID-19 infection after de-isolation. Data from 56 non-hospitalized patients diagnosed with COVID-19 infection referred to our nuclear medicine department from July–December 2020 for a perfusion only SPECT/CT study or a ventilation perfusion SPECT/CT study were collected. Images were assessed for the presence and type of perfusion defects. The CT component of the study was also assessed for the presence of mosaic attenuation and COVID pneumonia changes. Results Thirty-two (57.1%) cases had perfusion defects. There were 20 (35.7%) cases with defects in keeping with pulmonary embolism, 17 (30.4%) cases with defects associated with mosaic attenuation but not due to pulmonary embolism, and 6 (10.7%) of cases with defects due to pulmonary infiltrates from COVID pneumonia. A total of 24 (42.9%) cases had mosaic attenuation on CT, with 10 (17.9%) of them showing a pattern likely consistent with shunting on the perfusion images. Conclusion Lung perfusion abnormalities are a common finding in non-hospitalized COVID-19 patients with mild disease. They are usually either due to pulmonary embolism, parenchymal infiltrates, or other causes of mosaic attenuation related to, but not specific to the pathophysiology of COVID-19 infection. The value of VQ SPECT/CT imaging is also shown in this study, in detecting and differentiating the various types of perfusion abnormalities.

Extended perfusion defects in lung perfusion-SPECT/CT in a case of fatal COVID-19 pneumonia

2021 ◽  
Author(s):  
Clemens Mingels ◽  
Bernd Vollnberg ◽  
Axel Rominger ◽  
Ali Afshar-Oromieh ◽  
Ian Alberts
Keyword(s):  
Lung Perfusion ◽  
Perfusion Spect ◽  
Perfusion Defects

scholarly journals Modeling lung perfusion abnormalities to explain early COVID-19 hypoxemia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jacob Herrmann ◽  
Vitor Mori ◽  
Jason H. T. Bates ◽  
Béla Suki
Keyword(s):  
Mathematical Model ◽  
Pulmonary Embolism ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Lung Perfusion ◽  
The Novel ◽  
Venous Admixture ◽  
Pulmonary Vasoconstriction ◽  
Injured Lung ◽  
Perfusion Defects ◽  
Novel Coronavirus

Abstract Early stages of the novel coronavirus disease (COVID-19) are associated with silent hypoxia and poor oxygenation despite relatively minor parenchymal involvement. Although speculated that such paradoxical findings may be explained by impaired hypoxic pulmonary vasoconstriction in infected lung regions, no studies have determined whether such extreme degrees of perfusion redistribution are physiologically plausible, and increasing attention is directed towards thrombotic microembolism as the underlying cause of hypoxemia. Herein, a mathematical model demonstrates that the large amount of pulmonary venous admixture observed in patients with early COVID-19 can be reasonably explained by a combination of pulmonary embolism, ventilation-perfusion mismatching in the noninjured lung, and normal perfusion of the relatively small fraction of injured lung. Although underlying perfusion heterogeneity exacerbates existing shunt and ventilation-perfusion mismatch in the model, the reported hypoxemia severity in early COVID-19 patients is not replicated without either extensive perfusion defects, severe ventilation-perfusion mismatch, or hyperperfusion of nonoxygenated regions.

scholarly journals Incidental detection of a lung perfusion defect suspicious of pulmonary embolism on labelled white blood cell quality control imaging—case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Osayande Evbuomwan ◽  
Gerrit Engelbrecht
Keyword(s):  
Pulmonary Embolism ◽  
Quality Control ◽  
Nuclear Medicine ◽  
Blood Cell ◽  
White Blood Cell ◽  
Incidental Findings ◽  
Lung Perfusion ◽  
Perfusion Defects ◽  
The Right ◽  
Cell Study

Abstract Background Incidental findings could be a very important observation in various nuclear medicine studies. There have been few cases of incidental findings of perfusion abnormalities on early quality control images of the lungs during radiolabeled white blood cell studies. This study is the first to detect perfusion defects on the early quality control images of the lungs during a labelled white blood cell study suspicious of pulmonary embolism in an unknown but treated COVID-19 patient. Case presentation We present a 40-year-old male who was referred to our department for a nuclear medicine 99mTc HMPAO-labelled white blood cell study to rule out osteomyelitis of his right foot. Early 5-min quality control images of his lungs revealed two perfusion defects in the right lung. A suspicion of pulmonary embolism was made, and a perfusion only SPECT/CT study the next day confirmed the suspicion of pulmonary embolism in one of the defects, with a possible fissure sign as a differential. Conclusion There has been an increase in the incidence of lung perfusion abnormalities and pulmonary embolism during the COVID-19 pandemic. Some of these may be detected as incidental findings on early lung quality control images of radiolabeled white blood cell studies.

COMPARISON OFDUAL ENERGY CT LUNG PERFUSION VERSUS LUNG VENTILATION/PERFUSION SCINTIGRAPHY IN PULMONARY EMBOLISM

2020 ◽  
Vol 71 (2) ◽  
pp. 399-410
Author(s):  
Khaled Abdelghany ◽  
Noha Osman ◽  
Eman Geneidi ◽  
Hala Abou Senna ◽  
Ahmed Nasr ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Lung Ventilation ◽  
Lung Perfusion ◽  
Perfusion Scintigraphy
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