scholarly journals Axillary fibromatosis with radiological-pathological correlation: a case report and literature review

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Flávia Sprenger ◽  
Sofia Tokars Kluppel ◽  
Valmir Vicente Filho ◽  
Ana Carolina Staats ◽  
Raul Alberto Anselmi Junior ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Color Doppler ◽  
Young Patients ◽  
Microscopic Analysis ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Histopathological Study ◽  
Diagnosis Delay ◽  
Beta Catenin ◽  
Clear Cytoplasm

Abstract Background The term fibromatosis refers to a spectrum of soft tissue tumors resulting from the unbridled proliferation of fibroblasts, with high infiltrative power. It is a rare neoplasm, with an incidence of about 3 cases per million. Most common sites include the abdominal wall and cavity, chest wall, scapular area, and the limbs, rarely affecting the axilla. Imaging plays a major role in surgical planning and clinical follow-up. Differential diagnosis with other soft tissue tumors may be arduous, but a correct evaluation is fundamental. Case presentation A 33-year-old case is reported for the evaluation of a palpable hardened and immobile left axillary nodule. The ultrasound reveals a solid, elongated, heterogeneous, poorly delimited, infiltrative lesion observed in the left axillary hollow, with no detectable flow in the color Doppler mode. At magnetic resonance imaging, the same elongated and expansive lesion was better defined, revealing its irregular contours, alternating areas of hypo- and hyperintense on T2, heterogeneous enhancement, and no signs of signal decay on in- and out-of-phase sequences. Due to its growth and local invasion potential, surgical excision was performed. The microscopic analysis showed long and uniform spindle cell fascicles, with clear cytoplasm and wavy nuclei, arranged in different directions, included in collagen stroma. Immunohistochemistry was positive for nuclear beta-catenin, confirming the diagnosis of fibromatosis. Conclusion Imaging methods reflect the heterogeneous nature of the lesion. This study demonstrates the importance of using a multidisciplinary approach in addition to imaging tests and histopathological study for better diagnosis and therapeutic planning. The high infiltrative power always must be reminded of, since it affects young patients and diagnosis delay can lead to mutilating surgeries.

Color doppler ultrasonography of soft-tissue masses

1998 ◽  
Vol 39 (4) ◽  
pp. 421-426 ◽  
Author(s):  
R. Lagalla ◽  
A. Iovane ◽  
G. Caruso ◽  
M. Lo Bello ◽  
L. E. Derchi
Keyword(s):  
Soft Tissue ◽  
Doppler Ultrasonography ◽  
Color Doppler ◽  
Soft Tissue Tumors ◽  
Color Doppler Ultrasonography ◽  
Tissue Mass ◽  
Vascular Impedance ◽  
The Us ◽  
Soft Tissue Masses ◽  
Malignant Lesions

Purpose: To evaluate the capability of color Doppler ultrasonography to differentiate between benign and malignant soft-tissue tumors. Material and Methods: We reviewed the ultrasonographic (US) and color Doppler (CD) findings in 46 consecutive patients with a palpable periskeletal mass. The presence of 3 or more vascular hila and of tortuous and irregular internal vessels within the lesions was considered an indication of malignancy. The CD diagnosis was compared with that obtained at US alone. Results: The sensitivity and specificity of CD were respectively 85% and 92%; these values were higher than those obtained at US alone, respectively 75% and 50%. Arteriovenous malformations presented as lesions with large internal vessels that had low vascular impedance and were easily diagnosed. The waveform patterns within solid tumors were not specific. Conclusion: At present, US is commonly employed to confirm the presence of a suspected soft-tissue mass, to locate it accurately, and to indicate its nature. CD findings enhance the role of the US technique in such lesions. The combined use of US and CD can allow the differentiation of benign from malignant lesions, and thus provide a better basis for treatment.

Histopathological study of soft tissue tumors: A three year experience in tertiary care centre

2015 ◽  
Vol 2 (3) ◽  
pp. 141
Author(s):  
Preeti Rihal Chakrabarti ◽  
Suvadip Chakrabarti ◽  
Ajita Pandit ◽  
Purti Agrawal ◽  
Shilpi Dosi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tertiary Care ◽  
Soft Tissue Tumors ◽  
Histopathological Study ◽  
Care Centre ◽  
Tertiary Care Centre

scholarly journals MUSCULOSKELETAL HYDATIDOSIS: REPORT OF TWO СASES AND REVIEW THE LITERATURE

2013 ◽  
Vol 18 (1) ◽  
pp. 39-43
Author(s):  
A. M. Bronstein ◽  
N. A. Malishev ◽  
Yu. A. Legonkov ◽  
G. H. Musaev ◽  
S. N. Jarov ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Preoperative Evaluation ◽  
Surgical Excision ◽  
Fine Needle Biopsy ◽  
Soft Tissue Tumors ◽  
Hydatid Cysts ◽  
Tissue Mass ◽  
Life Threatening ◽  
Atypical Localization

Musculoskeletal system is rarely involved by hydatid cyst, the larvalform of Echinococcus granulosus. Two cases of intramuscular hydatid cysts within thigh musculature are being reported with the intent of highlighting this atypical localization of the disease. Preoperative computerized tomography suggested an unusual location of echinococcus. Since the soft tissue tumors may be confused with hydatid cysts, preoperative evaluation of these patients is critical for proper handling during surgery to avoid life-threatening complications. Surgical excision with postoperative antihelmenthics formed the main modality. These cases emphasize that especially in endemic areas to avoid fine-needle biopsy and the risk of spillage of cyst contents hydatidosis should be included in differential diagnosis of any soft tissue mass.

Soft-tissue tumors in young patients

2000 ◽  
pp. 351-396
Author(s):  
Cheryl M. Coffin ◽  
Mariana M. Cajaiba ◽  
Justin M. M. Cates ◽  
Rita Alaggio
Keyword(s):  
Soft Tissue ◽  
Young Patients ◽  
Soft Tissue Tumors

Aberrant Immunohistochemical Expression in Nonrhabdomyosarcoma Soft Tissue Sarcomas of Infancy: Retrospective Review of Clinical Material

2002 ◽  
Vol 5 (6) ◽  
pp. 579-586 ◽  
Author(s):  
Neil James Sebire ◽  
Alan Drummond Ramsay ◽  
Gillian Levitt ◽  
Marian Malone ◽  
Rupert Anthony Risdon
Keyword(s):  
Soft Tissue ◽  
Smooth Muscle Actin ◽  
Diagnostic Category ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Mitotic Rate ◽  
Soft Tissue Tumors ◽  
Undifferentiated Sarcoma ◽  
Infantile Fibrosarcoma ◽  
Infantile Hemangiopericytoma

Malignant soft tissue tumors other than rhabdomyosarcoma (RMS) are uncommon in infancy, representing approximately 5% of pediatric sarcomas. The pathological categorization of non-RMS soft tissue malignancies from these young patients is complicated by variation in both morphologic and immunohistochemical features. A search covering an 11-year period identified 19 patients presenting at birth or in infancy with a clinical or referral diagnosis of soft tissue sarcoma. After histologic and immunohistochemical review, nine of these tumors were classified as primitive neuroectodermal tumor (PNET), three as infantile hemangiopericytoma (HPC), two as infantile fibrosarcoma (FS), and five as undifferentiated sarcoma. Those identified as undifferentiated sarcomas showed an atypical spindle and ovoid cell morphology, with cellular pleomorphism and high mitotic rate, but lacking the fascicular growth pattern of classic infantile fibrosarcoma. Immunohistochemical staining in this group showed variable weak positivity for a range of markers (desmin, smooth muscle actin, Myo-D1, PGP, NSE, S100, CO56, cytokeratin, and CD99), and did not fit readily into any distinct diagnostic category. In this series, tumors classified as soft tissue PNETs had a poor prognosis despite aggressive treatment. However, once RMS, PNET, and other rare specific lesions are excluded, the remaining undifferentiated sarcomas, despite their unusual morphology and immunohistochemistry, appear to behave in a similar favorable manner to infantile fibrosarcoma.

scholarly journals Statistically Based Survival Rate Estimation in Patients with Soft Tissue Tumors

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 7
Author(s):  
B. Şerban ◽  
Z. Panti ◽  
M. Nica ◽  
M. Pleniceanu ◽  
M. Popa ◽  
...  
Keyword(s):  
Survival Rate ◽  
Soft Tissue ◽  
Healing Rate ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Rate Estimation ◽  
Differentiation Degree ◽  
Histopathological Type

Abstract Introduction. Although most soft tissue tumors are benign, with a high healing rate after surgical excision, there is a variety of malignant tumors with differences in progression and prognosis. The study aims to assess the survival rate in patients diagnosed with this pathology, based on the patient’s characteristics (age, gender, race), as well as the tumor’s (histological type, differentiation degree, location and size). Materials and methods. The retrospective study included a group of 103 patients diagnosed in our department during 2010 and 2017. Considering the high healing rate of benign tumors, only the group of neoplastic patients (45 cases) was involved in the survival rate estimation, assessing tumor characteristics and individual comorbidities. Within this lot, we emphasized a predominance of neoplasm in patients aged over 50 years (32 cases), men (29 cases), and localization of the neoplasm in the thigh (23 cases). The predominant histopathological type, liposarcoma, was diagnosed in 67% of the cases, with dimensions over 6 cm and with local extension. Results. There have been significant variations in mortality between the different histological subtypes (liposarcoma vs. synovial sarcoma). Local recurrences were shown in 18 cases of liposarcoma in the first 2 years after the surgical excision, with an increased aggressiveness of this neoplasm in men over 50 years. 12 cases developed distant metastasis, and, until the end of the study, 7 deaths were reported in 3 cases involving associated comorbidities. Conclusions. The five-year survival is inversely proportional to the extent of the tumor and the local invasion, as well as to the age of the patient. It is difficult to appreciate an overall survival rate in the context of a heterogeneous group of tumors so it must be evaluated for every histological subtype taking into account the patient’s particularities.

scholarly journals Statistically based survival rate estimation in patients with soft tissue tumors

2018 ◽  
Vol 1 (2) ◽  
pp. 84-89
Author(s):  
Bogdan Serban ◽  
Zsombor Panti ◽  
Mihai Nica ◽  
Marian Pleniceanu ◽  
Mihnea Popa ◽  
...  
Keyword(s):  
Survival Rate ◽  
Soft Tissue ◽  
Healing Rate ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Rate Estimation ◽  
Differentiation Degree ◽  
Histopathological Type

Abstract Although most soft tissue tumors are benign, with a high healing rate after surgical excision, there is a variety of malignant tumors with differences in progression and prognosis. The study aimed to assess the survival rate in patients diagnosed with this pathology, based on the patient’s characteristics (age, gender, race), as well as the tumor’s histological type, differentiation degree, location and size. The retrospective study included a group of 103 patients diagnosed during 2010 and 2017 in our department. Considering the high healing rate of benign tumors, only the group of neoplastic patients (45 cases) was involved in the survival rate estimation, assessing tumor characteristics and individual comorbidities. Within this lot, we emphasized a predominance of neoplasm in patients aged over 50 years (32 cases), men (29 cases), and localization of the neoplasm in the thigh (23 cases). The predominant histopathological type, liposarcoma, was diagnosed in 67% of the cases, with dimensions over 6 cm and with local extension. There have been significant variations in mortality between the different histological subtypes (liposarcoma vs. synovial sarcoma). Local recurrences were showed in 18 cases of liposarcoma in the first 2 years after the surgical excision, with an increased aggressiveness of this neoplasm in men over 50 years. 12 cases developed distant metastasis, and until the end of the study, 7 deaths were reported in 3 cases involving associated comorbidities. The five-year survival is inversely proportional to the extent of the tumor and the local invasion, as well as to the age of the patient. An overall survival rate is difficult to appreciate in the context of a heterogeneous group of tumors so it must be evaluated for every histological subtype taking into account the patient’s particularities.

Ultrasound and Color Doppler Ultrasound of Soft Tissue Tumors and Tumorlike Lesions

2017 ◽  
pp. 3-40 ◽  
Author(s):  
Jan Gielen ◽  
Filip Vanhoenacker ◽  
Ruth Ceulemans ◽  
Marnix Van Holsbeeck ◽  
Henk-Jan Van der Woude ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Soft Tissue Tumors
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