Diagnostic performance of PET/CT in primary malignant bone tumors

Abstract Background Nowadays, PET/CT plays a substantial role in the diagnosis of different types of tumor by its ability to provide combined functional and anatomic imaging in the same session. The purpose of this study is to evaluate the added value of PET/CT in staging and re-staging of primary malignant bone tumors. Results Out of the studied 40 patients, 7 patients were referred for primary staging of different types of histologically proven primary malignant bone tumors, their FDG-PET/CT studies yielded additional diagnostic information in 28.6% of them. Thirty three patients were referred either for assessment of treatment response or for follow-up to detect any viable lesions; FDG-PET/CT was more sensitive and specific than CT in follow-up and assessment of treatment response with PET/CT sensitivity 94.4%, specificity 86.7%, and total accuracy 90.9% and CT sensitivity 88.2%, specificity 81.2%, and total accuracy 84.8%. Conclusions PET/CT was an accurate imaging modality in evaluation of primary malignant bone tumors regarding tumor staging, assessment of therapeutic response and detection of metastatic disease as compared to CT.

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Clinical presentation and treatment response in patients with polymyalgia rheumatica and giant cell arteritis during a 40-week follow-up

Rheumatology Advances in Practice ◽

10.1093/rap/rkab091 ◽

2021 ◽

Author(s):

Amir Emamifar ◽

Søren Hess ◽

Torkell Ellingsen ◽

Oke Gerke ◽

Ziba Ahangarani Farahani ◽

...

Keyword(s):

Giant Cell Arteritis ◽

Treatment Response ◽

Giant Cell ◽

Clinical Features ◽

Polymyalgia Rheumatica ◽

Fdg Pet ◽

Temporal Artery Biopsy ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Objectives To study the clinical features of polymyalgia rheumatica and/or giant cell arteritis (PMR/GCA) and clinical predictors of treatment response during a 40-week follow-up period. Method Clinical data on 77 patients with newly diagnosed PMR/GCA who were treated by oral glucocorticoids were gathered at baseline and during 40-week follow-up period. A unilateral temporal artery biopsy (TAB) and 18 F-FDG PET/CT were undertaken at diagnosis. In total, each patient was seen at 5 occasions i.e. baseline, weeks 4, 16, 28, and 40. Treatment response was assessed considering clinical evaluations and results of inflammatory markers. Results Of 77 patients (49(63.6%) female, mean age : 71.8 ± 8.0), 64(83.1%) patients had pure PMR, 10(13.0%) concomitant PMR and GCA, and 3(3.9%) pure GCA. The patients reported clinical symptoms except scalp pain and duration of morning stiffness improved significantly at week 4 and remained lower at week 40 compared with the relative frequencies at baseline. Besides, all components of physical examination showed significant improvement and remained lower at week 40 compared with the baseline. 68.7%, 62.9%, 44.1% and 33.3% of the patients had a complete response at weeks 4, 16, 28, and 40, respectively. Several clinical features including female gender, younger age, fewer relapse, and lower level of baseline ESR were significantly associated with a better treatment response. Treatment response during follow-up period was independent of TAB results and FDG uptakes on 18 F-FDG PET/CT at diagnosis. Conclusion Obtaining valid disease specific outcome measures for evaluating treatment efficacy in PMR and GCA, that can be applied universally is clearly an unmet clinical need. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov, NCT02985424

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FDG-PET/CT in the Assessment of Treatment Response after Oncologic Treatment of Head and Neck Squamous Cell Carcinoma

Clinical Medicine Insights Ear Nose and Throat ◽

10.4137/cment.s16399 ◽

2014 ◽

Vol 7 ◽

pp. CMENT.S16399 ◽

Cited By ~ 6

Author(s):

Harri Keski-Säntti ◽

Timo Mustonen ◽

Jukka Schildt ◽

Kauko Saarilahti ◽

Antti A. Mäkitie

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Treatment Response ◽

Predictive Value ◽

Fdg Pet ◽

Residual Disease ◽

Pet Ct ◽

Fdg Pet Ct

Background In many centers, 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG–PET/CT) is used to monitor treatment response after definitive (chemo)radiotherapy [(C)RT] for head and neck squamous cell carcinoma (HNSCC), but its usefulness remains somewhat controversial. We aimed at assessing the accuracy of FDG-PET/CT in detecting residual disease after (C)RT. Method All HNSCC patients with FDG-PET/CT performed to assess treatment response 10–18 weeks after definitive (C)RT at our institution during 2008–2010 were included. The patient charts were reviewed for FDG-PET/CT findings, histopathologic findings, and follow-up data. The median follow-up time for FDG-PET/CT negative patients was 26 months. Results Eighty-eight eligible patients were identified. The stage distribution was as follows: I, n = 1; II, n = 15; III, n = 17; IV, n = 55. The negative predictive value, positive predictive value, specificity, sensitivity, and accuracy of FDG-PET/CT in detecting residual disease were 87%, 81%, 94%, 65%, and 85%, respectively. The corresponding specific figures for the primary tumor site were 91%, 71%, 94%, 59%, and 86% and for the neck 93%, 100%, 100%, 75%, and 94%, respectively. Conclusions In patients who have received definitive (C)RT for HNSCC, post-treatment FDG-PET/CT has good potential to guide clinical decision-making. Patients with negative scan can safely be followed up clinically only, while positive scan necessitates tissue biopsies or a neck dissection to rule out residual disease.

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Screening in asymptomatic SDHx mutation carriers: added value of 18F-FDG PET/CT at initial diagnosis and 1-year follow-up

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-015-3003-z ◽

2015 ◽

Vol 42 (6) ◽

pp. 868-876 ◽

Cited By ~ 14

Author(s):

C. Lepoutre-Lussey ◽

C. Caramella ◽

F. Bidault ◽

D. Déandreis ◽

A. Berdelou ◽

...

Keyword(s):

Fdg Pet ◽

Initial Diagnosis ◽

Added Value ◽

Mutation Carriers ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Role of 18F-FDG PET/CT in the Management of Patients Affected by HHV-8-Associated Multicentric Castleman’s Disease

Hemato ◽

10.3390/hemato2020024 ◽

2021 ◽

Vol 2 (2) ◽

pp. 383-391

Author(s):

Domenico Albano ◽

Francesco Bertagna ◽

Elisabetta Cerudelli ◽

Francesco Dondi ◽

Raffaele Giubbini

Keyword(s):

Treatment Response ◽

Fdg Pet ◽

Castleman’S Disease ◽

Multicentric Castleman’S Disease ◽

Deauville Score ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Multicentric Castleman's Disease

Our aim was to investigate the usefulness of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the diagnosis, treatment response evaluation, and follow-up of human herpesvirus-8 (HHV-8)-associated multicentric Castleman’s disease (MCD). Fifteen patients with histologically diagnosis of HHV-8-associated MCD were retrospectively included. For all patients, a 18F-FDG PET/CT scan was performed before any treatment for diagnosis and PET/CT scans after Rituximab (4 cycles) for the evaluation of treatment response; moreover, 22 PET/CT were performed during the follow-up to check disease status. To evaluate treatment response, we applied Deauville criteria. PET/CT findings were compared with other conventional imaging (CI) findings. At diagnosis, 18F-FDG PET/CT showed an increased FDG-uptake in all cases corresponding to lymph nodes and confirming the MCD. The average SUVmax of the FDG avid lesions were 8.75, average lesion-to-liver SUVmax ratio was 3.6, and average lesion-to-blood pool SUVmax ratio was 3.9. After first-line therapy, 18F-FDG PET/CT resulted negative (Deauville score < 4) in seven patients and positive in the remaining eight (Deauville score 4–5). A negative restaging PET/CT was associated with a lower risk of relapse. During follow-up, PET/CT detected the presence of relapse or progression in 5 (23%) cases with an accuracy higher than CI. 18F-FDG PET/CT seems to be an useful tool in studying HHV-8-associated MCD both at diagnosis and during follow-up.

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The Value of FDG PET/CT in Treatment Response Assessment, Follow-Up, and Surveillance of Lung Cancer

American Journal of Roentgenology ◽

10.2214/ajr.16.16532 ◽

2017 ◽

Vol 208 (2) ◽

pp. 420-433 ◽

Cited By ~ 38

Author(s):

Sara Sheikhbahaei ◽

Esther Mena ◽

Anusha Yanamadala ◽

Siddaling Reddy ◽

Lilja B. Solnes ◽

...

Keyword(s):

Lung Cancer ◽

Treatment Response ◽

Fdg Pet ◽

Response Assessment ◽

Pet Ct ◽

Treatment Response Assessment ◽

Fdg Pet Ct

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Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT

Pediatric Radiology ◽

10.1007/s00247-012-2517-9 ◽

2012 ◽

Vol 43 (1) ◽

pp. 86-92 ◽

Cited By ~ 9

Author(s):

Anat Ilivitzki ◽

Lea Radan ◽

Miriam Ben-Arush ◽

Ora Israel ◽

Ayelet Ben-Barak

Keyword(s):

Treatment Response ◽

Fdg Pet ◽

Low Dose ◽

Hodgkin Disease ◽

Added Value ◽

Low Dose Ct ◽

Pet Ct ◽

Fdg Pet Ct

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Prediction of lymph node metastase in NSCLC

Onkologische Welt ◽

10.1055/s-0038-1632899 ◽

2010 ◽

Vol 01 (05) ◽

pp. 219-226 ◽

Cited By ~ 1

Author(s):

F. Beyer ◽

B. Buerke ◽

J. Gerss ◽

K. Scheffe ◽

M. Puesken ◽

...

Keyword(s):

Lymph Nodes ◽

Fdg Pet ◽

Automatic Segmentation ◽

Correlation Coefficients ◽

Mediastinal Lymph Nodes ◽

Intra Class Correlation ◽

Axial Diameter ◽

Pet Ct ◽

Fdg Pet Ct

SummaryPurpose: To distinguish between benign and malignant mediastinal lymph nodes in patients with NSCLC by comparing 2D and semiautomated 3D measurements in FDG-PET-CT.Patients, material, methods: FDG-PET-CT was performed in 46 patients prior to therapy. 299 mediastinal lymph-nodes were evaluated independently by two radiologists, both manually and by semi-automatic segmentation software. Longest-axial-diameter (LAD), shortest-axial-diameter (SAD), maximal-3D-diameter, elongation and volume were obtained. FDG-PET-CT and clinical/FDG-PET-CT follow up examinations and/or histology served as the reference standard. Statistical analysis encompassed intra-class-correlation-coefficients and receiver-operator-characteristics-curves (ROC). Results: The standard of reference revealed involvement in 87 (29%) of 299 lymph nodes. Manually and semi-automatically measured 2D parameters (LAD and SAD) showed a good correlation with mean

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