scholarly journals Neuropathic pain in primary knee osteoarthritis patients: correlation with physical function, quality of life, disease severity, and serum beta nerve growth factor levels

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Shereen R. Kamel ◽  
Radwa S. Ibrahim ◽  
Hend M. Moens ◽  
Rania M. Mohammed
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Disease Severity ◽  
Nerve Growth ◽  
Pain Symptoms

Abstract Background Neuropathic mechanisms are thought to play a role in knee osteoarthritis (KOA) pain. Neuropathic pain questionnaires can promote diagnosis of a neuropathic component. Thus, we aimed to assess the frequency of neuropathic pain in primary KOA patients (using clinical questionnaires) and to investigate its correlation with socio-demographic factors, physical function, quality of life, disease severity, and serum beta nerve growth factor (β-NGF) levels. Results Seventy primary KOA patients were included. Neuropathic pain was detected in 52.9% of patients based on Douleur Neuropathique en 4 Questions (DN4) questionnaire and in 38.6% of patients based on Leeds assessment neuropathic pain symptoms and signs questionnaire (LANSS). Serum β-NGF levels were significantly higher in KOA patients than controls (P<0.0001), and in KOA patients with neuropathic pain compared with patients with non-neuropathic pain. DN4 score was positively correlated with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, stiffness, and physical function, and it was also negatively correlated with Osteoarthritis knee hip quality of life questionnaire (OAKHQOL) pain scores (rs=0.459, P<0.001; rs= 0.258, P= 0.031; rs= 0.307, P= 0.010; rs = −0.337, P= 0.004, respectively), while LANSS scale was positively correlated with symptom duration, WOMAC stiffness, Lequesne pain, and Lequesne index (rs= 0.260, P= 0.020; rs= 0.343, P= 0.004; rs= 0.344, P= 0.004; rs= 0.322, P= 0.007) and negatively correlated with OAKHQOL physical, OAKHQOL mental health, OAKHQOL social support, and total OAKHQOL scores (rs= −0.258, P= 0.031;rs= −0.254, P= 0.034; rs= −0.283, P= 0.018; rs= −0.261, P= 0.029 respectively). Conclusions Neuropathic pain symptoms are frequent in primary KOA patients. KOA patients with neuropathic pain have worse quality of life, extreme disability, and higher serum β-NGF levels. Nerve growth factor inhibitors could have a potential role for not only relieving pain in KOA patients but also improving functional disability and quality of life in these patients.

scholarly journals Neuropathic pain in knee osteoarthritis

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Uğur Güngör Demir ◽  
Ali Nail Demir ◽  
Naciye Füsun Toraman
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
Neuropathic Pain ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Body Mass ◽  
Symptom Duration ◽  
Group 2 ◽  
Group 1

Abstract Background This study aimed to investigate the relationship between the neuropathic pain in knee osteoarthritis with the body composition, anthropometric and postural features, physical function, and quality of life. Methods Patients with primary knee osteoarthritis, 50–70 years of age, were included in the study and divided into Group 1 with neuropathic pain and Group 2 with no neuropathic pain according to Douleur Neuropathique-4. The groups were compared in terms of demographic, clinical, radiological, laboratory findings and anthropometric measurements, body composition, physical function tests, osteoarthritis severity, quality of life, and posturography. Results 200 patients were included in the study. 98 (82.6% female) were in Group 1 and 102 (74.5% female) in Group 2. Age was higher in Group 1 compared to Group 2 [61 (50–70) and 57.5 (50–70), respectively, p = 0.03]. Symptom duration was also longer in Group 1 (5.21 ± 4.76 and 3.38 ± 3.58, p = 0.002). Body mass indices were 31.9 ± 5.6 and 30.1 ± 4.8 (p = 0.015). Kellgren–Lawrence class, Western Ontario and McMaster Osteoarthritis Index and Short Form-36 scores were more unfavorable in Group 1. Although fall risk was similar, stability and Fourier harmony indices were impaired in Group 1 compared to Group 2 especially when the visual and proprioceptive input was blocked. Conclusions Almost half of the patients with knee osteoarthritis had neuropathic pain which was associated with longer symptom duration and higher age, lower education, higher body mass index, more severe radilogical findings, worse pain perception, lower physical function and quality of life, and lower stability.

CCL01, a novel formulation composed of cuscuta seeds and Lactobacillus paracasei NK112, enhances memory function via nerve growth factor-mediated neurogenesis

2021 ◽  
Author(s):  
In Gyoung Ju ◽  
Seong-Min Hong ◽  
Soo-Won Yun ◽  
Eugene Huh ◽  
Dong-Hyun Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Memory Function ◽  
Nutritional Supplements ◽  
Lactobacillus Paracasei ◽  
Memory Decline ◽  
Nerve Growth

Memory decline occurs due to various factors, including stress, depression, and aging, and lowers the quality of life. Several nutritional supplements and probiotics have been used to enhance memory function,...

Neuropathic pain symptoms in inflammatory hand osteoarthritis (OA) lower quality of life and may require another approach than anti-inflammatory treatment

2021 ◽  
Vol 29 ◽  
pp. S237-S238
Author(s):  
C. van der Meulen ◽  
L.A. van de Stadt ◽  
F.P. Kroon ◽  
M.C. Kortekaas ◽  
A. Boonen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Hand Osteoarthritis ◽  
Anti Inflammatory ◽  
Pain Symptoms

scholarly journals Biochemical and physical treatment in rat neuropathic pain and nerve growth factor

PAIN RESEARCH ◽  
2004 ◽  
Vol 19 (4) ◽  
pp. 141-149 ◽  
Author(s):  
Mitsuharu Nishi ◽  
Toshizo Ishikawa ◽  
Yoshihiro Matsumoto ◽  
Nobuo Katsube ◽  
Naruto Tateishi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Physical Treatment ◽  
Nerve Growth

scholarly journals Impact of Tart Cherry Juice on Joint Flexibility and Pain in Individuals with Self-Reported Knee Osteoarthritis (P01-030-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chen Du ◽  
Sarah Collins Chapman ◽  
Young-Hoo Kwon ◽  
Parakat Vijayagopal ◽  
Shanil Juma
Keyword(s):  
Quality Of Life ◽  
Hyaluronic Acid ◽  
Placebo Group ◽  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Tart Cherry ◽  
Daily Consumption ◽  
Cherry Juice ◽  
Igfbp 3

Abstract Objectives The purpose of this study was to examine the daily consumption of tart cherry juice in comparison to a placebo juice on symptoms associated with knee osteoarthritis in both men and woman, age 45–79 years old, for a treatment period of 120 days. Methods In a randomized, double-blind control trial, a total of 66 adults with self-reported symptomatic knee OA, were randomized to either consume a 16 oz of tart cherry juice (TCJ) or a placebo juice daily for 4 months. Pain, mobility, plasma biomarkers of cartilage metabolism were evaluated at baseline, 2 months and 4 months. Pain, stiffness, and impact on quality of life were assessed using Self-administered Modified Short Form McGill Pain Questionnaire, while flexibility of the afflicted joint(s) was assessed via range of motion assessment (ROM). Plasma biomarkers related to cartilage metabolism such as glycoprotein 39 (YKL-40), hyaluronic acid, insulin-like growth factor(IGF)-1, and insulin-like growth factor binding protein (IGFBP-3) were determined. Results A total of 57 participants completed the study with an attrition rate of 9%. Pain and impact on quality of life decreased significantly at mid-point in the TCJ group, but these improvements were not maintained at the final time point. At midpoint, right knee ROM increased significantly in the TCJ at mid-point, but did not maintain significant at the end of the treatment period. Knee extension and knee flexion also improved significantly in the TCJ group from baseline to midpoint, while there was no significant change in the placebo group. The TCJ group had an overall significant decrease in plasma YKL-40, a marker of cartilage destruction, while no changes were observed in the placebo group. A significant decrease in the plasma IGF-1 and a non-significant up trend in IGFBP-3 were observed in the placebo group, while in the TCJ group no changes in IGF-1 and a non-significant decrease in IGFBP-3 was observed. There were no changes in the hyaluronic acid in the TCJ group during the study duration, but a non-significant up trending was noticed in the placebo group. Conclusions The findings of the study suggest that daily consumption of tart cherry juice results in improvement in mobility, relief of pain-related symptoms and quality of life, and selective markers of cartilage health. Funding Sources Cherry Marketing Institute.

scholarly journals Short-term cryotherapy did not substantially reduce pain and had unclear effects on physical function and quality of life in people with knee osteoarthritis: a randomised trial

2019 ◽  
Vol 65 (4) ◽  
pp. 215-221 ◽  
Author(s):  
Lucas Ogura Dantas ◽  
Carolina Carreira Breda ◽  
Paula Regina Mendes da Silva Serrao ◽  
Francisco Aburquerque-Sendín ◽  
Ana Elisa Serafim Jorge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Randomised Trial ◽  
Short Term

The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs

2017 ◽  
Vol 31 (5) ◽  
pp. 582-595 ◽  
Author(s):  
Lucie Brosseau ◽  
Jade Taki ◽  
Brigit Desjardins ◽  
Odette Thevenot ◽  
Marlene Fransen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pain Relief ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Tai Chi ◽  
Statistical Significance ◽  
Clinical Importance ◽  
Exercise Programs ◽  
High Quality

Objective: To identify effective mind-body exercise programs and provide clinicians and patients with updated, high-quality recommendations concerning non-traditional land-based exercises for knee osteoarthritis. Methods: A systematic search and adapted selection criteria included comparative controlled trials with mind-body exercise programs for patients with knee osteoarthritis. A panel of experts reached consensus on the recommendations using a Delphi survey. A hierarchical alphabetical grading system (A, B, C+, C, D, D+, D-) was used, based on statistical significance ( P < 0.5) and clinical importance (⩾15% improvement). Results: The four high-quality studies identified demonstrated that various mind-body exercise programs are promising for improving the management of knee osteoarthritis. Hatha Yoga demonstrated significant improvement for pain relief (Grade B) and physical function (Grade C+). Tai Chi Qigong demonstrated significant improvement for quality of life (Grade B), pain relief (Grade C+) and physical function (Grade C+). Sun style Tai Chi gave significant improvement for pain relief (Grade B) and physical function (Grade B). Conclusion: Mind-body exercises are promising approaches to reduce pain, as well as to improve physical function and quality of life for individuals with knee osteoarthritis.

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