Assessment of aggression, sexual behavior and fertility in adult male rat following long-term ingestion of four industrial metals salts

To investigate the role of the pineal gland in the long-term suppression of gonadotrophin secretion induced by prolactin, the effects of pinealectomy were studied in adult male rats with hyperprolactinaemia produced by the transplantation of two pituitary glands under the kidney capsule. Pinealectomy had no effect on basal levels of LH, FSH or prolactin. The presence of pituitary transplants induced a significant twofold increase in prolactin levels and a prolonged suppression in both LH and FSH. These changes were not affected by pinealectomy. Castration resulted in a similar rise in plasma levels of LH and FSH in rats with and without pituitary transplants. In control rats this rise in LH and FSH was reduced by testosterone-containing silicone elastomer implants (s.c) of 10 mm in length and delayed by implants of 30 mm. These rises in LH and FSH were significantly delayed (10-mm implant) or abolished (30-mm implant) in rats with pituitary transplants indicating an increase in sensitivity of the hypothalamic-pituitary axis to the negative feedback effects of testosterone in these animals compared to controls. These responses were not affected by pinealectomy. These results suggest that the pineal gland is not involved in the mechanism whereby pituitary grafts, possibly through their secretion of prolactin, cause long-term suppression of gonadotrophin secretion.

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Dose-dependent decrements in adult male rat sexual behavior after neonatal clorimipramine treatment

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(95)02276-7 ◽

1996 ◽

Vol 54 (3) ◽

pp. 605-609 ◽

Cited By ~ 24

Author(s):

G Vogel

Keyword(s):

Sexual Behavior ◽

Adult Male ◽

Male Rat ◽

Adult Male Rat ◽

Dose Dependent

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Maternal exposure to picrotoxin modifies the response of the GABAA receptor during sexual behavior of adult male rat offspring

Behavioural Pharmacology ◽

10.1097/fbp.0b013e3283586072 ◽

2012 ◽

Vol 23 (7) ◽

pp. 703-709 ◽

Cited By ~ 1

Author(s):

Maria M. Bernardi ◽

Thiago B. Kirsten ◽

Elizabeth Teodorov ◽

Ana C.Z. Baso ◽

Fabio C. Prosdocimi ◽

...

Keyword(s):

Sexual Behavior ◽

Gabaa Receptor ◽

Adult Male ◽

Maternal Exposure ◽

Male Rat ◽

Rat Offspring ◽

Adult Male Rat

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Effects of prenatal exposure to chrysotile asbestos on hippocampal neurogenesis and long-term behavioral changes in adult male rat offspring

Behavioural Brain Research ◽

10.1016/j.bbr.2019.111962 ◽

2019 ◽

Vol 371 ◽

pp. 111962 ◽

Cited By ~ 1

Author(s):

Ehsan Raeis-Abdollahi ◽

Fatemeh Nabavizadeh ◽

Leila Tajik ◽

Hamid Reza Sadeghipour

Keyword(s):

Prenatal Exposure ◽

Adult Male ◽

Hippocampal Neurogenesis ◽

Behavioral Changes ◽

Male Rat ◽

Chrysotile Asbestos ◽

Rat Offspring ◽

Adult Male Rat

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Tramadol Promotes Oxidative Stress, Fibrosis, Apoptosis, Ultrastructural and Biochemical alterations in the Adrenal Cortex of Adult Male Rat with Possible Reversibility after Withdrawal

Microscopy and Microanalysis ◽

10.1017/s1431927620001397 ◽

2020 ◽

Vol 26 (3) ◽

pp. 509-523 ◽

Cited By ~ 1

Author(s):

Amany Mohamed Shalaby ◽

Adel Mohamed Aboregela ◽

Mohamed Ali Alabiad ◽

Dina Fouad El Shaer

Keyword(s):

Adrenal Cortex ◽

Adult Male ◽

Smooth Endoplasmic Reticulum ◽

Dehydroepiandrosterone Sulfate ◽

Male Rats ◽

Male Rat ◽

Control Group ◽

Biochemical Alterations ◽

Adult Male Rat

AbstractTramadol is a centrally acting analgesic drug, used for the management of moderate to severe pain in a variety of diseases. The long-term use of tramadol can induce endocrinopathy. This study aimed to evaluate the effect of tramadol dependence on the adrenal cortex and the effect of its withdrawal. Thirty adult male rats were divided into three experimental groups: the control group, the tramadol-dependent group that received increasing therapeutic doses of tramadol orally for 1 month, and the recovery group that received tramadol in a dose and duration similar to the previous group followed by a withdrawal period for another month. Specimens from the adrenal cortex were processed for histological, immunohistochemical, enzyme assay, and quantitative real-time PCR (RT-qPCR) studies. Tramadol induced a significant increase in malondialdehyde level and a significant decrease in the levels of glutathione peroxidase and superoxide dismutase. A significant decrease in the levels of adrenocorticotrophic hormones, aldosterone, cortisol, corticosterone, and dehydroepiandrosterone sulfate was also detected. Severe histopathological changes in the adrenal cortex were demonstrated in the form of disturbed architecture, swollen cells, and shrunken cells with pyknotic nuclei. Inflammatory cellular infiltration and variable-sized homogenized areas were also detected. A significant increase in P53 and Bax immunoreaction was detected and confirmed by RT-qPCR. The ultrastructural examination showed irregular, shrunken adrenocorticocytes with dense nuclei. Dilated smooth endoplasmic reticulum, mitochondria with disrupted cristae, and numerous coalesced lipid droplets were also demonstrated. All these changes started to return to normal after the withdrawal of tramadol. Thus, it was confirmed that the long-term use of tramadol can induce severe adrenal changes with subsequent insufficiency.

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