Exercise for depression

Depression is a common and important cause of morbidity and mortality worldwide. It is commonly treated with antidepressants and/or psychological therapy, but some people prefer alternative approaches such as exercise. There are a number of theoretical reasons why exercise may improve depression. This is an update of a review first published in 2009.

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Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches

Heart Failure Reviews ◽

10.1007/s10741-020-10004-6 ◽

2020 ◽

Vol 26 (1) ◽

pp. 11-21

Author(s):

Susan Stienen ◽

Ankeet Bhatt ◽

João Pedro Ferreira ◽

Muthiah Vaduganathan ◽

James Januzzi ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Beneficial Effect ◽

Natriuretic Peptide ◽

Guideline Adherence ◽

Morbidity And Mortality ◽

Methodological Issues ◽

Reduced Ejection Fraction ◽

Patients With Heart Failure ◽

Alternative Approaches

AbstractTreatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline adherence and uptitration, several trials have investigated a biomarker-guided strategy (using natriuretic peptide targets in specific), but although conceptually promising, these trials failed to show a consistent beneficial effect on outcomes. In this review, we discuss different methodological issues that may explain the failure of these trials and offer potential solutions. Moreover, alternative approaches to increase heart failure guideline adherence are evaluated.

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Alternative approaches to ultra-high resolution imaging

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100087562 ◽

1991 ◽

Vol 49 ◽

pp. 650-651

Author(s):

J.M. Cowley

Keyword(s):

High Resolution ◽

High Voltage ◽

High Resolution Electron Microscopy ◽

Crystal Defects ◽

High Resolution Imaging ◽

General Applicability ◽

Resolution Electron ◽

Radiation Resistant ◽

Resolution Imaging ◽

Alternative Approaches

By extrapolation of past experience, it would seem that the future of ultra-high resolution electron microscopy rests with the advances of electron optical engineering that are improving the instrumental stability of high voltage microscopes to achieve the theoretical resolutions of 1Å or better at 1MeV or higher energies. While these high voltage instruments will undoubtedly produce valuable results on chosen specimens, their general applicability has been questioned on the basis of the excessive radiation damage effects which may significantly modify the detailed structures of crystal defects within even the most radiation resistant materials in a period of a few seconds. Other considerations such as those of cost and convenience of use add to the inducement to consider seriously the possibilities for alternative approaches to the achievement of comparable resolutions.

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