On the value of P300 Event-Related Potentials in the Differential Diagnosis of Dementia

1984 ◽  
Vol 145 (6) ◽  
pp. 652-656 ◽  
Author(s):  
J. P. J. Slaets ◽  
C. Fortgens

SummaryThe possible value of event-related potentials (ERPs) in the differential diagnosis of dementia was investigated in a group of 42 demented elderly patients, 29 non-demented elderly patients, and 10 healthy young controls. The auditory evoked potentials were elicited by using target and non-target auditory stimuli. There was no significant difference in N100 and P200 latency between these groups. Our results indicate an age-related increase of P300 latency of 0.3 msec/year in the non-demented subjects. There was no significant difference in P300 latency between demented and non-demented patients, and the latencies vary widely within the groups of elderly patients.

2018 ◽  
Vol 15 (13) ◽  
pp. 1244-1260 ◽  
Author(s):  
Mirjana Babić Leko ◽  
Magdalena Krbot Skorić ◽  
Nataša Klepac ◽  
Fran Borovečki ◽  
Lea Langer Horvat ◽  
...  

Introduction: The pathological process of Alzheimer's disease (AD) in the brain likely begins 20-30 years earlier than the emergence of its first clinical symptoms and symptoms of AD often overlap with the symptoms of other primary causes of dementia. Therefore, it is crucially important to improve early and differential diagnosis of the disease. Event-related potentials (ERP) measured non-invasively by electroencephalography have shown diagnostic potential in AD. Aims: The aim of this study was to compare the efficiency of P300 and N200 potentials and reaction time (RT) with commonly used protein biomarkers measured in the cerebrospinal fluid (CSF), including amyloid β peptide (β1-42), total tau (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), tau protein phosphorylated at serine 199 (p-tau199), tau protein phosphorylated at threonine 231 (p-tau231), and visinin-like protein 1 (VILIP-1) in differential diagnosis of AD in mild cognitive impairment (MCI) and AD patients. Subjects: The study involved 49 AD patients, 28 patients with MCI, 4 healthy control subjects and 16 patients with other primary causes of dementia. Results: ERP (P300RT, N200RT, P300 counting and N200 counting) showed a moderate to strong correlation with protein CSF biomarkers. We confirmed previous observations of moderate to strong correlation between ERP and neuropsychological testing and showed that P300 latency and RT are shortened in AD patients on therapy with acetylcholinesterase inhibitors. Using ERP and RT, a predictive model for determination of AD likelihood in MCI patients was developed, detecting 56.3% of MCI patients with high risk for development of AD in our cohort. MCI patients with pathological levels of Aβ1-42 had prolonged P300 latency, indicating that a combination of ERP and CSF protein biomarkers could improve the differential diagnosis of AD in MCI patients. Additionally, the results suggested the potential of P300 latency in differentiating AD and FTD patients. Conclusion: Our data provide possible solutions for improvement of differential diagnosis of AD, and reveal that the diagnostic efficiency of CSF protein biomarkers t-tau, p-tau181, p-tau199, p-tau231 and VILIP-1 could be improved by adding ERP in clinical practice.


1986 ◽  
Vol 21 (12) ◽  
pp. 1123-1132 ◽  
Author(s):  
E. Gordon ◽  
C. Kraiuhin ◽  
A. Harris ◽  
R. Meares ◽  
A. Howson

Author(s):  
Juciclara Rinaldi ◽  
Marília Silveira ◽  
Renata Kochhann ◽  
Maria Alice De Mattos Pimenta Parente

Resumo: A tarefa de reconto de histórias apresenta diferença entre idosos sem e com demência, pois aqueles lembram maior número de informações do que estes. Com o objetivo de verificar se, desde as etapas iniciais, os pacientes com Demência de Alzheimer (DA) leve e moderada se mostram sensíveis à tarefa de compreensão de leitura textual, analisaram-se 40 idosos: 25 com DAs prováveis, sendo 12 leves e 13 moderados; e 15 sem demência, com escolaridade de 4 anos ou mais. Os pacientes foram avaliados através do Mini-Exame do Estado Mental (MEEM), Questionário Sociodemográfico, Escala Reduzida de Depressão Geriátrica da Yesavage (GDS-15) e quatro histórias, com quatro frases cada, as quais apresentavam estrutura textual descritiva e narrativa. A compreensão textual mostrou ser uma tarefa sensível aos participantes com demência, cujo desempenho foi significativamente pior do que o dos idosos saudáveis. Não houve diferença estatisticamente significativa quanto às estruturas textuais das histórias. Contudo, à medida que aumentaram os elementos de estrutura narrativa nas histórias, os participantes sem demência e os com demência leve apresentaram melhora na recordação. Os tipos de acréscimos às histórias mais freqüentes no grupo com DA foram reconstrução e inferência. Os resultados sugerem que a avaliação das habilidades lingüísticas pode auxiliar no diagnóstico diferencial precoce da Demência. Palavras-chave: Demência de Tipo Alzheimer. Compreensão textual. Memória. Linguagem. Abstract: The task of recall stories presents a difference between the elderly with dementia and the ones without dementia because the first can remember a greater number of information than the latter. This study aimed to verify if patients with mild or moderate dementia are sensible to the task of textual reading comprehension since the first stages of the disease 40 elderly patients were analyzed: 25 with probable AD, from which 12 were mild and 13 were moderate, and 15 without dementia, with a minimum schooling of 4 years. The patients were evaluated through the MEEM, Sociodemographic Questionary and the GDS-15, besides four stories, each with four sentences, which presented a narrative and descriptive textual structure. The textual comprehension showed to be a sensitive task to the patients with dementia, whose performance was significantly worse than the one of the healthy elderly. There was no statistically significant difference regarding the textual structures of the stories. However, as the elements of narrative structure in the stories increased, the participants without dementia and the ones with mild dementia showed an improvement in remembering the stories. The kinds of additions to the stories that the patients with AD made more frequently were reconstruction and inference. The results suggest that the evaluation of the linguistic abilities may help in the early differential diagnosis of dementia. Keywords: Alzheimer’s disease. Textual comprehension. Memory. Language.


2002 ◽  
Vol 13 (01) ◽  
pp. 001-013 ◽  
Author(s):  
James Jerger ◽  
Rebecca Estes

We studied auditory evoked responses to the apparent movement of a burst of noise in the horizontal plane. Event-related potentials (ERPs) were measured in three groups of participants: children in the age range from 9 to 12 years, young adults in the age range from 18 to 34 years, and seniors in the age range from 65 to 80 years. The topographic distribution of grand-averaged ERP activity was substantially greater over the right hemisphere in children and seniors but slightly greater over the left hemisphere in young adults. This finding may be related to age-related differences in the extent to which judgments of sound movement are based on displacement versus velocity information.


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