Tardive Dyskinesia in Bipolar Affective Disorder: Relationship to Lithium Therapy

1989 ◽  
Vol 155 (1) ◽  
pp. 55-57 ◽  
Author(s):  
Timothy G. Dinan ◽  
Dora Kohen
Keyword(s):  
Tardive Dyskinesia ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Affective Illness ◽  
Psychiatric Admissions ◽  
Age Related ◽  
Related Increase

Forty patients under the age of 60 years with a DSM–III diagnosis of bipolar affective disorder were examined for the presence of tardive dyskinesia. The overall prevalence was 22.5%, with an age-related increase. Patients with and without tardive dyskinesia did not differ in terms of duration of affective illness or exposure to neuroleptics, but those patients with tardive dyskinesia had significantly more psychiatric admissions and were on lithium for significantly greater lengths of time.

Plasma Lithium Levels and Therapeutic Outcome in the Prophylaxis of Affective Disorders: A Retrospective Study

1982 ◽  
Vol 140 (6) ◽  
pp. 619-622 ◽  
Author(s):  
S. P. Sashidharan ◽  
R. J. McGuire ◽  
A. I. M. Glen
Keyword(s):  
Retrospective Study ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Favourable Outcome ◽  
Therapeutic Outcome ◽  
Lithium Therapy ◽  
Affective Illness

SummaryPatients receiving prophylactic lithium therapy for primary affective disorder during a four year period were studied for recurrence of affective illness. Patients who had affective episodes during this period did not differ from those who remained well in age, sex or diagnosis. Those with a favourable outcome had spent significantly less time at serum lithium levels above 0.9 mmol/litre than those who had a recurrence of affective episodes.

Cognitive impairment, clinical course and treatment history in out-patients with bipolar affective disorder: relationship to tardive dyskinesia

1989 ◽  
Vol 19 (4) ◽  
pp. 897-902 ◽  
Author(s):  
John L. Waddington ◽  
Katherine Brown ◽  
Jane O'Neill ◽  
Patrick McKeon ◽  
Anthony Kinsella
Keyword(s):  
Tardive Dyskinesia ◽  
Affective Disorder ◽  
Cognitive Flexibility ◽  
Clinical Course ◽  
Bipolar Affective Disorder ◽  
Involuntary Movements ◽  
Impaired Performance ◽  
Treatment History ◽  
Individual Vulnerability ◽  
History Of

SYNOPSISClinical, neuropsychological and psychopharmacological characteristics were investigated for their ability to distinguish individuals with and without involuntary movements (tardive dyskinesia), among a population of 40 out-patients with bipolar affective disorder and a history of exposure to neuroleptics and lithium. Impaired performance on a test of cognitive flexibility bore the primary association with both the presence and the severity of involuntary movements. The additional relationships identified emphasized further that individual vulnerability to involuntary movements appeared to be associated not with greater duration or dosage of treatment, but with features of the bipolar illness, including number and type of affective episodes, for which that treatment was prescribed.

scholarly journals NON PITTING TYPE PEDAL EDEMA WITH LITHIUM: A CASE REPORT

2016 ◽  
Vol 9 (1) ◽  
pp. 323
Author(s):  
Parvathypriya C. ◽  
Jeslyn Mary Philip ◽  
Christeena George ◽  
Lakshmi R.
Keyword(s):  
Affective Disorder ◽  
Dose Escalation ◽  
Lithium Treatment ◽  
Lithium Concentration ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Psychotic Symptoms ◽  
Drug Induced ◽  
Serum Lithium Concentration ◽  
Pedal Edema

<p><strong>Objective: </strong>To report a case of lithium induced bilateral nonpitting pedal edema.</p><p><strong>Methods: </strong>The clinical data of a bipolar affective disorder patient with current episode of mania and psychotic symptoms who experienced bilateral non pitting pedal edema with lithium.</p><p><strong>Results: </strong>The patient was a 29 yr old female who developed bilateral non-pitting type pedal edema with lithium therapy with normal plasma lithium level (0.72mEq/l). She is a known case of bipolar affective disorder (BPAD) was admitted to psychiatry department with episode of mania with psychotic symptoms. She had history of drug induced hypersensitivity reaction with eosinophilia and systemic symptoms (DRESS) with oxcarbazepine and so the drug was discontinued and was started on tablet lithium 400 mg twice daily. On admission here, the dose of lithium was increased to 1200 mg/day. The patient gradually improved but she developed bilateral non-pitting pedal edema. Serum lithium concentration was normal and there were no other early symptoms of lithium toxicity. But as the patient's distress further increased with increasing pedal edema, it was decided to stop lithium altogether and to maintain the patient on tablet quetiapine 800 mg therapy for BPAD. Within one week of stopping lithium the edema on both her feet decreased significantly. Causality was assessed by naranjo causality assessment scale and a probable relationship was obtained between lithium and pedal edema with a score of 6.</p><p><strong>Conclusion: </strong>This case emphasises that regular physical examination and laboratory investigations are important for patients who are on lithium therapy. Clinicians should always be careful while initiating lithium treatment in a patient with respect to the initial dose and dose escalation even after a period of successful therapy with lithium, as minor dose escalation can cause major changes in the serum lithium concentration and thereby the patient’s tolerability to lithium.</p>

Bipolar Affective Disorder in Down's Syndrome

1987 ◽  
Vol 151 (1) ◽  
pp. 116-117 ◽  
Author(s):  
Martin McLaughlin
Keyword(s):  
Affective Disorder ◽  
Recent Literature ◽  
Bipolar Affective Disorder ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Affective Illness

Recent literature reports suggest that the presence of Down's syndrome precludes the development of mania. A case of bipolar affective illness in a man with Down's syndrome is presented.

Antinuclear autoantibodies in relation to bipolar affective disorder and lithium therapy

1996 ◽  
Vol 11 (1) ◽  
pp. 50-52 ◽  
Author(s):  
B Spivak ◽  
M Radwan ◽  
P Bartur ◽  
R Mester ◽  
A Weizman
Keyword(s):  
Affective Disorder ◽  
Antinuclear Antibodies ◽  
Lithium Treatment ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Healthy Controls ◽  
Antinuclear Autoantibodies ◽  
Dna Antibodies ◽  
Bipolar Patients ◽  
Drug Free

SummaryWe investigated the presence of antinuclear antibodies (ANA) in 63 drug free and lithium treated bipolar patients as compared to 37 healthy controls. Increased frequency of positive ANA was detected in bipolar patients in comparison to controls (19% vs 5%, respectively, P < 0.05). This finding was unrelated to lithium treatment. No antinative DNA antibodies or antihistone reactive antibodies were detected among the ANA positive subjects.

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