Antinuclear autoantibodies in relation to bipolar affective disorder and lithium therapy

1996 ◽  
Vol 11 (1) ◽  
pp. 50-52 ◽  
Author(s):  
B Spivak ◽  
M Radwan ◽  
P Bartur ◽  
R Mester ◽  
A Weizman
Keyword(s):  
Affective Disorder ◽  
Antinuclear Antibodies ◽  
Lithium Treatment ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Healthy Controls ◽  
Antinuclear Autoantibodies ◽  
Dna Antibodies ◽  
Bipolar Patients ◽  
Drug Free

SummaryWe investigated the presence of antinuclear antibodies (ANA) in 63 drug free and lithium treated bipolar patients as compared to 37 healthy controls. Increased frequency of positive ANA was detected in bipolar patients in comparison to controls (19% vs 5%, respectively, P < 0.05). This finding was unrelated to lithium treatment. No antinative DNA antibodies or antihistone reactive antibodies were detected among the ANA positive subjects.

scholarly journals NON PITTING TYPE PEDAL EDEMA WITH LITHIUM: A CASE REPORT

2016 ◽  
Vol 9 (1) ◽  
pp. 323
Author(s):  
Parvathypriya C. ◽  
Jeslyn Mary Philip ◽  
Christeena George ◽  
Lakshmi R.
Keyword(s):  
Affective Disorder ◽  
Dose Escalation ◽  
Lithium Treatment ◽  
Lithium Concentration ◽  
Bipolar Affective Disorder ◽  
Lithium Therapy ◽  
Psychotic Symptoms ◽  
Drug Induced ◽  
Serum Lithium Concentration ◽  
Pedal Edema

<p><strong>Objective: </strong>To report a case of lithium induced bilateral nonpitting pedal edema.</p><p><strong>Methods: </strong>The clinical data of a bipolar affective disorder patient with current episode of mania and psychotic symptoms who experienced bilateral non pitting pedal edema with lithium.</p><p><strong>Results: </strong>The patient was a 29 yr old female who developed bilateral non-pitting type pedal edema with lithium therapy with normal plasma lithium level (0.72mEq/l). She is a known case of bipolar affective disorder (BPAD) was admitted to psychiatry department with episode of mania with psychotic symptoms. She had history of drug induced hypersensitivity reaction with eosinophilia and systemic symptoms (DRESS) with oxcarbazepine and so the drug was discontinued and was started on tablet lithium 400 mg twice daily. On admission here, the dose of lithium was increased to 1200 mg/day. The patient gradually improved but she developed bilateral non-pitting pedal edema. Serum lithium concentration was normal and there were no other early symptoms of lithium toxicity. But as the patient's distress further increased with increasing pedal edema, it was decided to stop lithium altogether and to maintain the patient on tablet quetiapine 800 mg therapy for BPAD. Within one week of stopping lithium the edema on both her feet decreased significantly. Causality was assessed by naranjo causality assessment scale and a probable relationship was obtained between lithium and pedal edema with a score of 6.</p><p><strong>Conclusion: </strong>This case emphasises that regular physical examination and laboratory investigations are important for patients who are on lithium therapy. Clinicians should always be careful while initiating lithium treatment in a patient with respect to the initial dose and dose escalation even after a period of successful therapy with lithium, as minor dose escalation can cause major changes in the serum lithium concentration and thereby the patient’s tolerability to lithium.</p>

scholarly journals Standards of Lithium Treatment Monitoring In a Teaching Hospital in South India among Bipolar Affective Disorder

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Dr. Sureshkumar Ramasamy ◽  
Dr. Shilpa Srinivasan ◽  
Dr. Shree Aarthi Ramanathan
Keyword(s):  
Serum Creatinine ◽  
Affective Disorder ◽  
Lithium Treatment ◽  
Bipolar Affective Disorder ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Retrospective Audit ◽  
Bipolar Patients

Background: Lithium is a commonly used drug with a narrow therapeutic index, it has significant adverse effects on kidney and thyroid, and is life threatening during intoxication. Maudsley guidelines on managing bipolar affective disorder patients (BPAD) with lithium recommends checking weight at baseline and every 3rd month, serum lithium after 7th day thereafter 3 months once, renal function test and serum thyroid stimulating hormone (TSH) at baseline and 6 months once. Aim: To evaluate whether Pre-Lithium workup and monitoring is done in Bipolar affective disorder (BPAD) patients initiated on Lithium as per Maudsley prescribing guidelines in psychiatry. Method: Retrospective audit conducted in a tertiary care hospital on lithium monitoring in BPAD patients treated with lithium atleast for six months compared against Maudsley prescribing guidelines. Results: Among medical records of 114 bipolar patients fulfilling study criteria, weight and serum lithium at baseline was checked in 100% of patients; serum creatinine and TSH at baseline along with lithium at 3rd month was done in 83.3%, 78.9% and 68.4% of patients respectively. Maudsley guidelines for serum creatinine, TSH and lithium level at 6th month were met only in 43.8%, 43.8% and 72.8% of patients respectively. Conclusion: The quality of lithium monitoring in bipolar patients falls well short of accepted standards; Hence addressing the issues in monitoring and following a standard protocol can improve the effectiveness of treatment and quality of life of patients.

scholarly journals Use of Dermatoglyphic Parameters as Possible Markers in Bipolar Affective Disorder

2021 ◽  
Vol 11 (7) ◽  
pp. 385-393
Author(s):  
Amit Kumar Pal ◽  
Sagarika Ray ◽  
Jishnu Bhattacharya
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Control Group ◽  
Healthy Controls ◽  
Ridge Count ◽  
Primordial Prevention ◽  
And Gender ◽  
The Individual ◽  
Bipolar Patients

Background: Bipolar affective disorder is an episodic illness characterized by fluctuating mood states. Association of dermatoglyphic traits with bipolar affective disorder has been observed in various studies. This study was undertaken to evaluate epidermal ridge patterns in bipolar patients as compared to healthy controls attending a super speciality district hospital in West Bengal. Context and purpose of study: Establishing dermatoglyphic parameters as biomarkers for early diagnosis and consequently, prompt intervention in bipolar affective disorder will ensure a greater scope of recovery, and thus promote a better quality of life for the individual as well as lower the burden of disease for the society. Methods: Quantitative dermatoglyphic parameters namely, Total Finger Ridge Count (TFRC), Total A-B Ridge Count (TABRC), and ATD Angle of 100 bipolar patients were compared to 100 age and gender matched healthy controls. Results: Statistically significant differences were found on comparing the dermatoglyphic parameters between cases and controls. TFRC was found to be decreased while ATD angle was increased in bipolar cases, as compared to the control group. However, no significant change was observed in TABRC between the two groups. Conclusions: This study found a significant association between dermatoglyphic pattern anomalies and the development of bipolarity. This may offer a scope of primordial prevention of bipolar disorder in future. Key words: Dermatoglyphics, ridge pattern, bipolar disorder, Total Finger Ridge Count (TFRC), Total A-B Ridge Count (TABRC), ATD angle.

P-187 - Bipolar affective disorder and dissociation - comparison with healthy controls

2012 ◽  
Vol 27 ◽  
pp. 1
Author(s):  
K. Latalova ◽  
J. Prasko Pavlov ◽  
D. Kamaradova ◽  
A. Grambal ◽  
T. Diveky ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Healthy Controls

scholarly journals Altered Magnetic Resonance White-Matter T1 Values in Patients with Affective Disorder

1990 ◽  
Vol 157 (1) ◽  
pp. 107-110 ◽  
Author(s):  
R. J. Dolan ◽  
A. M. Poynton ◽  
P. K. Bridges ◽  
M. R. Trimble
Keyword(s):  
White Matter ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Normal Control Group ◽  
Proton Relaxation ◽  
Control Group ◽  
Frontal Lobe Dysfunction ◽  
Unipolar Disorder ◽  
Frontal White Matter ◽  
Bipolar Patients

The MRI T1 proton relaxation values were assessed in 14 patients with bipolar affective disorder and 10 with a unipolar disorder and a matched normal control group. The T1 values in the frontal white matter of patients significantly exceeded those of the controls. This difference was accounted for by an increase in T1 values in the frontal white matter of unipolar patients: the values for bipolar patients alone did not differ from those for controls. These preliminary findings support a hypothesis of frontal lobe dysfunction mediating pathological changes in mood.

838 – Level of dissociation in patients with bipolar affective disorder compared with healthy controls

2013 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
K. Latalova ◽  
J. Prasko ◽  
T. Diveky ◽  
M. Cerna ◽  
A. Grambal ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Healthy Controls

P01-210-Bipolar affective disorder and dissociation – comparison with healthy controls

2011 ◽  
Vol 26 (S2) ◽  
pp. 211-211
Author(s):  
K. Latalova ◽  
J. Prasko ◽  
D. Kamaradova ◽  
A. Kovacsova ◽  
A. Grambal ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Clinical Symptoms ◽  
Bipolar Affective Disorder ◽  
Demographic Variables ◽  
University Hospital ◽  
Healthy Controls ◽  
Dissociative Experiences ◽  
Gender And Education ◽  
Clinical Global Impression Severity ◽  
Psychiatric Department

IntroductionAccording to recent findings, certain clinical symptoms of the patients suffering from affective and anxiety disorder can be related to dissociation. The aim of our study is to examine if the level of dissociation in bipolar affective disorder differ from the level of dissociation in healthy volunteers.Methods41 patients suffering from bipolar disorder (51.2% females), and 198 healthy controls (71.2% females) were included in the study. The patients with bipolar affective disorder in remission of the illness were recruited from the Outpatient psychiatric department of Psychiatry Clinic of University hospital Olomouc. Patients were psychiatrically assessed and the state of the disorder was evaluated by experienced psychiatrist. Only patients in remission of the disorder, evaluated as 1 or 2 points of clinical global impression - severity scale, were included into the study. All participants were assessed with the Dissociative Experiences Scale (DES).ResultsThe groups didn’t differ in demographic variables like age, gender and education. Patients had significantly higher mean score on the DES and pathological DES than healthy controls.ConclusionOur results suggest that the level of psychological dissociation in bipolar affective patients is higher than in healthy controls.Supported by grant IGA MZ ČR NT11047

Bipolar Affective Disorder in Old Age

1980 ◽  
Vol 136 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Kenneth Shulman ◽  
Felix Post
Keyword(s):  
Retrospective Study ◽  
Affective Disorder ◽  
Old Age ◽  
Bipolar Affective Disorder ◽  
Bipolar Disorders ◽  
Long Period ◽  
Bipolar Patients ◽  
Depressive Episodes ◽  
Recurrent Nature

SummaryIn a retrospective study of 67 elderly bipolar patients the first manic attack occurred at about age 60, often after a long period from the time of the first affective episode, after which further depressive episodes occurred. This calls into question Perris’ criteria for unipolar diagnosis. Among the men, a preponderance of cerebral-organic disorders was found. The evidence for sub-classification of bipolar disorders into secondary or symptomatic manias is discussed. The recurrent nature of the illness in old age stresses the need for further evaluation of lithium prophylaxis.

scholarly journals DEMOGRAPHIC VARIABLES ASSOCIATED WITH DRUG USE IN BIPOLAR PATIENTS

2021 ◽  
Vol 30 (03) ◽  
pp. 114-119
Author(s):  
Aysha Rashid ◽  
Mariam Haroon ◽  
Sumira Qambar Bokhari ◽  
Aysha Butt ◽  
Nauman Mazhar ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Drug Abuse ◽  
Drug Use ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Treatment Compliance ◽  
Bipolar Patient ◽  
Cross Sectional ◽  
The Mean ◽  
Bipolar Patients

Background: Substance Use is highly associated with bipolar affective disorder, however the reason for the co-occurrence is unknown. It was evident that if a bipolar patient use  drug of abuse his outcome will be poor. Either it can directly trigger the affective symptoms, or may affect the treatment compliance indirectly. Aims: The objective of this study was to study the demographic correlates of drug abuse in patients with bi-polar affective disorder. Method: Cross-Sectional research design and non-probability consecutive sampling was used to collect data from a private clinic in Lahore. Data was comprised of 368 patients of bipolar disorder. Results: Out of a total of 368 bipolar patients, drug abuse was found in 147 patients that is 39.9%. The results showed that the mean age of the patients was 31.03 ±5.837; mean monthly income was 229597.82 ±164626.77 PKR. The mean duration of illness was 6.54 ±5.157. The mean number of drugs used was 2 ±0.875. The mean cost of drug was 29945.7 ±19068.8 PKR. The mean number of hospitalization was 2.47 ±1.694. Association  between drug use and  occupation of  bipolar patients (0.006), factors leading to initiation of drug use (0.000), family history of drug use (0.001), current episode (0.000) and the type of drugs used (0.000)  was statistically significant. Conclusion: The cause and effect relationship between drug use and bipolar disorder cannot be clearly identified. However occupation of the patient, reasons of initiating drugs, drug abuse in family, current episode as well as  type of drugs used have  significant association  with drug abuse in bipolar patients .

scholarly journals Impulsivity as a Risk Factor for Suicide in Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Przemysław Zakowicz ◽  
Maria Skibińska ◽  
Karolina Wasicka-Przewoźna ◽  
Bartosz Skulimowski ◽  
Filip Waśniewski ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Suicide Risk ◽  
Iowa Gambling Task ◽  
Strong Predictor ◽  
Bipolar Affective Disorder ◽  
Self Report ◽  
Continuous Performance Task ◽  
Character Inventory ◽  
The Difference ◽  
Bipolar Patients

The accurate assessment of suicide risk in psychiatric, especially affective disorder diagnosed patients, remains a crucial clinical need. In this study, we applied temperament and character inventory (TCI), Barratt impulsiveness scale 11 (BIS-11), PEBL simple reaction time (SRT) test, continuous performance task (CPT), and Iowa gambling task (IGT) to seek for variables linked with attempted suicide in bipolar affective disorder group (n = 60; attempters n = 17). The main findings were: strong correlations between self-report tool scores and objective parameters in CPT; the difference between attempters and non-attempters was found in the number of correctly responded trials in IGT; only one parameter differed between attempters and non-attempters in BPI diagnosis; and no significant differences between suicide attempters and non-attempters in TCI, BIS-11, and SRT were found. These justify the conclusion that impulsivity itself is not a strong predictor, and used as a single variable might not be sufficient to indicate the high suicide risk group among bipolar patients.

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