Substance misuse in first-episode psychosis: 15-month
                        prospective follow-up study

BackgroundWell-designed prospective studies of substance misuse in first-episode psychosis can improve our understanding of the risks associated with comorbid substance misuse and psychosis.AimsTo examine the potential effects of substance misuse on in-patient admission and remission and relapse of positive symptoms in first-episode psychosis.MethodThe study was a prospective 15-month follow-up investigation of 103 patients with first-episode psychosis recruited from three mental health services.ResultsSubstance misuse was independently associated with increased risk of in-patient admission, relapse of positive symptoms and shorter time to relapse of positive symptoms after controlling for potential confounding factors. Substance misuse was not associated with remission or time to remission of positive symptoms. Heavy substance misuse was associated with increased risk of in-patient admission, relapse and shorter time to relapse.ConclusionsSubstance misuse is an independent risk factor for a problematic recovery from first-episode psychosis.

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THE INFLUENCE OF SUBSTANCE MISUSE IN THE FIRST EPISODE PSYCHOSIS ON THE COURSE AND OUTCOME: 3 YEARS PROSPECTIVE FOLLOW-UP STUDY

Schizophrenia Research ◽

10.1016/j.schres.2010.02.519 ◽

2010 ◽

Vol 117 (2-3) ◽

pp. 309

Author(s):

Dragoslava D. Gugleta ◽

Tosic Golubovic M. Suzana ◽

Violeta V. Slavkovic ◽

Stankovic Jankovic S. Dora

Keyword(s):

Substance Misuse ◽

First Episode Psychosis ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis

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Factors influencing relapse during a 2-year follow-up of first-episode psychosis in a specialized early intervention service

Psychological Medicine ◽

10.1017/s0033291707002656 ◽

2008 ◽

Vol 38 (11) ◽

pp. 1585-1593 ◽

Cited By ~ 45

Author(s):

A. Malla ◽

R. Norman ◽

L. Bechard-Evans ◽

N. Schmitz ◽

R. Manchanda ◽

...

Keyword(s):

Risk Factors ◽

Substance Abuse ◽

Early Intervention ◽

First Episode Psychosis ◽

First Episode ◽

Positive Symptoms ◽

Adherence To Medication ◽

Episode Psychosis ◽

Time To Relapse

BackgroundDifferential association of risk factors associated with relapse following treatment of first-episode psychosis (FEP) have not been studied adequately, especially for patients treated in specialized early intervention (SEI) services, where some of the usual risk factors may be ameliorated.MethodConsecutive FEP patients treated in an SEI service over a 4-year period were evaluated for relapse during a 2-year follow-up. Relapse was based on ratings on the Scale for Assessment of Positive Symptoms (SAPS) and weekly ratings based on the Life Chart Schedule (LCS). Predictor variables included gender, duration of untreated psychosis (DUP), total duration of untreated illness (DUI), age of onset, pre-morbid adjustment, co-morbid diagnosis of substance abuse during follow-up and adherence to medication. Univariate analyses were followed by logistic regression for rate of relapse and survival analysis with the Cox proportional-hazards regression model for time to relapse as the dependent variables.ResultsOf the 189 eligible patients, 145 achieved remission of positive symptoms. A high rate of medication adherence (85%) and relatively low relapse rates (29.7%) were observed over the 2-year follow-up. A higher relapse rate was associated with a co-morbid diagnosis of substance abuse assessed during the follow-up period [odds ratio (OR) 2.84, 95% confidence interval (CI) 1.24–6.51]. The length of time to relapse was not associated with any single predictor.ConclusionsSpecialized treatment of substance abuse may be necessary to further reduce risk of relapse even after improving adherence to medication.

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Catatonia is associated with worse cognitive performance in patients with first-episode psychosis antipsychotic-naive: a 3-month follow-up study

10.26226/morressier.5971be84d462b80290b5267b ◽

2017 ◽

Author(s):

Jorge Cuevas Esteban

Keyword(s):

Cognitive Performance ◽

First Episode Psychosis ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis

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Emotional recognition in first episode psychosis: a follow-up study

10.26226/morressier.59d4913ad462b8029238a1e4 ◽

2017 ◽

Author(s):

Dina Bosnjak

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Emotional Recognition ◽

Follow Up Study ◽

Episode Psychosis

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Early Psychosis Prevention and Intervention Centre long-term follow-up study of first-episode psychosis: methodology and baseline characteristics

Early Intervention in Psychiatry ◽

10.1111/j.1751-7893.2007.00008.x ◽

2007 ◽

Vol 1 (1) ◽

pp. 49-60 ◽

Cited By ~ 31

Author(s):

Lisa P. Henry ◽

Meredith G. Harris ◽

G. Paul Amminger ◽

Hok Pan Yuen ◽

Susy M. Harrigan ◽

...

Keyword(s):

First Episode Psychosis ◽

Early Psychosis ◽

First Episode ◽

Prevention And Intervention ◽

Follow Up Study ◽

Episode Psychosis ◽

Long Term Follow Up ◽

Baseline Characteristics

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Patterns and predictors of hospitalisation in first-episode psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.178.6.518 ◽

2001 ◽

Vol 178 (6) ◽

pp. 518-523 ◽

Cited By ~ 47

Author(s):

Attila Sipos ◽

Glynn Harrison ◽

David Gunnell ◽

Shazad Amin ◽

Swaran P. Singh

Keyword(s):

Negative Symptoms ◽

First Episode Psychosis ◽

Psychiatric Services ◽

First Episode ◽

Psychotic Episode ◽

Duration Of Untreated Illness ◽

Specialist Services ◽

Increased Risk ◽

Episode Psychosis

BackgroundLittle is known about predictors of hospitalisation in patients with first-episode psychosis.AimsTo identify the pattern and predictors of hospitalisation of patients with a first psychotic episode making their first contact with specialist services.MethodThree-year follow-up of a cohort of 166 patients with a first episode of psychosis making contact with psychiatric services in Nottingham between June 1992 and May 1994.ResultsEighty-eight (53.0%) patients were admitted within 1 week of presentation; 32 (19.3%) were never admitted during the 3 years of follow-up. Manic symptoms at presentation were associated with an increased risk of rapid admission and an increased overall risk of admission; negative symptoms and a longer duration of untreated illness had an increased risk of late admission.ConclusionsCommunity-oriented psychiatric services might only delay, rather than prevent, admission of patients with predominantly negative symptoms and a longer duration of untreated illness. First-episode studies based upon first admissions are likely to be subject to selection biases, which may limit their representativeness.

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