Epidemiology of autism in adults across age groups and ability
                        levels

BackgroundThe epidemiology of autism in adults has relied on untested projections using childhood research.AimsTo derive representative estimates of the prevalence of autism and key associations in adults of all ages and ability levels.MethodComparable clinical diagnostic assessments of 7274 Adult Psychiatric Morbidity Survey participants combined with a population case-register survey of 290 adults with intellectual disability.ResultsThe combined prevalence of autism in adults of all ages in England was 11/1000 (95% CI 3–19/1000). It was higher in those with moderate to profound intellectual disability (odds ratio (OR) = 63.5, 95% CI 27.4–147.2). Male gender was a strong predictor of autism only in those with no or mild intellectual disability (adjusted OR = 8.5, 95% CI 2.0–34.9; interaction with gender, P = 0.03).ConclusionsFew adults with autism have intellectual disability; however, autism is more prevalent in this population. Autism measures may miss more women with autism.

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The Association Between Household Smoking Restrictions and Smoking Abstinence: Does Age Matter?

The Journal of Smoking Cessation ◽

10.1375/jsc.6.1.74 ◽

2011 ◽

Vol 6 (1) ◽

pp. 74-78 ◽

Cited By ~ 5

Author(s):

Rojiemiahd Edjoc

Keyword(s):

Young Adults ◽

Logistic Regression ◽

Odds Ratio ◽

Strong Predictor ◽

Age Groups ◽

Canadian Community Health Survey ◽

Smoking Abstinence ◽

Immigrant Status ◽

Smoking Restrictions ◽

Community Health Survey

AbstractAim: The purpose of this study is to explore how effective household smoking restrictions (HSRs) are in different age groups in predicting smoking abstinence. Methods: The study analysed the Canadian Community Health Survey (CCHS) cycle, 3.1. Smoking abstinence was defined as individuals who reported to not have smoked greater than 100 cigarettes (n = 1 024 578) and were selected for this analysis. Important covariates include sex, age, education and immigrant status. Logistic regression was used to assess the association between smoking household restrictions and smoking abstinence when taking covariates into consideration. Results: Individuals who implemented HSRs reported to be abstinent from smoking at 12% compared to those with no HSRs at 0.7%. When adjusted for covariates of interest, the odds ratio (OR) for smoking abstinence was 1.43 (95% confidence interval (CI): 1.04, 1.97; P < .026). It was found that age was a strong predictor of smoking abstinence particularly in youths at 3.11 (95% CI: 1.65, 5.84; P < .001) and young adults at 1.92 (95% CI: 1.44, 1.92; P < .001). Conclusion: It is suggested that HSRs is an important anti-tobacco socialisation tool in youths and young adults. Individuals living in a home with HSRs may internalise behavioural norms against the initiation or continuation of smoking.

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Faculty Opinions recommendation of Happiness across age groups: results from the 2007 National Psychiatric Morbidity Survey.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9893958.10601057 ◽

2011 ◽

Author(s):

Christer Allgulander

Keyword(s):

Psychiatric Morbidity ◽

Age Groups

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The Relationship Between Stress and Social Functioning in Adults With Autism Spectrum Disorder and Without Intellectual Disability

Autism Research ◽

10.1002/aur.1433 ◽

2014 ◽

Vol 8 (2) ◽

pp. 164-173 ◽

Cited By ~ 35

Author(s):

Lauren Bishop-Fitzpatrick ◽

Carla A. Mazefsky ◽

Nancy J. Minshew ◽

Shaun M. Eack

Keyword(s):

Autism Spectrum Disorder ◽

Intellectual Disability ◽

Social Functioning ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Adults With Autism ◽

The Relationship

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Comprehensive study of 28 individuals with SIN3A-related disorder underscoring the associated mild cognitive and distinctive facial phenotype

European Journal of Human Genetics ◽

10.1038/s41431-020-00769-7 ◽

2021 ◽

Author(s):

Meena Balasubramanian ◽

Alexander J. M. Dingemans ◽

Shadi Albaba ◽

Ruth Richardson ◽

Thabo M. Yates ◽

...

Keyword(s):

Intellectual Disability ◽

Protein Function ◽

Autism Spectrum ◽

Loss Of Function ◽

Mild Intellectual Disability ◽

Related Disorder ◽

Feeding Difficulties ◽

Facial Phenotype ◽

Novel Variants ◽

Common Behaviour

AbstractWitteveen-Kolk syndrome (OMIM 613406) is a recently defined neurodevelopmental syndrome caused by heterozygous loss-of-function variants in SIN3A. We define the clinical and neurodevelopmental phenotypes related to SIN3A-haploinsufficiency in 28 unreported patients. Patients with SIN3A variants adversely affecting protein function have mild intellectual disability, growth and feeding difficulties. Involvement of a multidisciplinary team including a geneticist, paediatrician and neurologist should be considered in managing these patients. Patients described here were identified through a combination of clinical evaluation and gene matching strategies (GeneMatcher and Decipher). All patients consented to participate in this study. Mean age of this cohort was 8.2 years (17 males, 11 females). Out of 16 patients ≥ 8 years old assessed, eight (50%) had mild intellectual disability (ID), four had moderate ID (22%), and one had severe ID (6%). Four (25%) did not have any cognitive impairment. Other neurological symptoms such as seizures (4/28) and hypotonia (12/28) were common. Behaviour problems were reported in a minority. In patients ≥2 years, three were diagnosed with Autism Spectrum Disorder (ASD) and four with Attention Deficit Hyperactivity Disorder (ADHD). We report 27 novel variants and one previously reported variant. 24 were truncating variants; three were missense variants and one large in-frame gain including exons 10–12.

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