scholarly journals Retinol kinetics in unsupplemented and vitamin A-retinoic acid supplemented neonatal rats: a preliminary model

2014 ◽  
Vol 55 (6) ◽  
pp. 1077-1086 ◽  
Author(s):  
Libo Tan ◽  
Amanda E. Wray ◽  
Michael H. Green ◽  
A. Catharine Ross
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Neonatal Rats ◽  
Preliminary Model

scholarly journals Compartmental modeling of whole-body vitamin A kinetics in unsupplemented and vitamin A-retinoic acid-supplemented neonatal rats

2014 ◽  
Vol 55 (8) ◽  
pp. 1738-1749 ◽  
Author(s):  
Libo Tan ◽  
Amanda E. Wray ◽  
Michael H. Green ◽  
A. Catharine Ross
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Whole Body ◽  
Compartmental Modeling ◽  
Neonatal Rats

scholarly journals Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal rats

2006 ◽  
Vol 47 (8) ◽  
pp. 1844-1851 ◽  
Author(s):  
A. Catharine Ross ◽  
Namasivayam Ambalavanan ◽  
Reza Zolfaghari ◽  
Nan-qian Li
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Neonatal Rats ◽  
Retinyl Ester ◽  
Ester Formation

scholarly journals Priming with Retinoic Acid, an Active Metabolite of Vitamin A, Increases Vitamin A Uptake in the Small Intestine of Neonatal Rats

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4275
Author(s):  
Yaqi Li ◽  
Cheng-Hsin Wei ◽  
J. Kalina Hodges ◽  
Michael H. Green ◽  
A. Catharine Ross
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Oral Dose ◽  
Canola Oil ◽  
Active Metabolite ◽  
Storage Capacity ◽  
Treatment Time ◽  
Neonatal Rats ◽  
Continuous Increase ◽  
Second Peak

Given that combined vitamin A (VA) and retinoic acid (RA) supplementation stimulated the intestinal uptake of plasma retinyl esters in neonatal rats, we administrated an RA dose as a pretreatment before VA supplementation to investigate the distinct effect of RA on intestinal VA kinetics. On postnatal days (P) 2 and 3, half of the pups received an oral dose of RA (RA group), while the remaining received canola oil as the control (CN). On P4, after receiving an oral dose of 3H-labeled VA, pups were euthanized at selected times (n = 4–6/treatment/time) and intestine was collected. In both CN and RA groups, intestinal VA mass increased dramatically after VA supplementation; however, RA-pretreated pups had relatively higher VA levels from 10 h and accumulated 30% more VA over the 30-h study. Labeled VA rapidly peaked in the intestine of CN pups and then declined from 13 h, while a continuous increase was observed in the RA group, with a second peak at 10 h and nearly twice the accumulation of 3H-labeled VA compared to CN. Our findings indicate that RA pretreatment may stimulate the influx of supplemental VA into the intestine, and the increased VA accumulation suggests a potential VA storage capacity in neonatal intestine.

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