Development of Novel Tools for the Diagnosis and Prognosis of Pheochromocytoma Using Peptide Marker Immunoassay and Gene Expression Profiling Approaches

AbstractGene expression profiling studies in human diseases have allowed better understanding of pathophysiological processes. In addition, they may lead to the development of new clinical tools to improve diagnosis and prognosis of patients. Most of these studies have been successfully performed for human cancers. Inspired by these results, researchers in the cardiovascular field have also started using large-scale transcriptional analysis to better understand and classify human cardiovascular disease. Here we provide an overview of the literature revealing new cardiac disease markers and encouraging results for further development of the expression profiling strategy for future clinical applications in cardiology.

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Gene expression profiling for the diagnosis and prognosis of acute myeloid leukaemia

Frontiers in Bioscience ◽

10.2741/3026 ◽

2008 ◽

Vol Volume (13) ◽

pp. 4605 ◽

Cited By ~ 6

Author(s):

Ken Mills

Keyword(s):

Gene Expression ◽

Acute Myeloid Leukaemia ◽

Gene Expression Profiling ◽

Myeloid Leukaemia ◽

Expression Profiling ◽

Diagnosis And Prognosis ◽

Acute Myeloid

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Impact of gene expression profiling in lymphoma diagnosis and prognosis

Histopathology ◽

10.1111/j.1365-2559.2010.03708.x ◽

2011 ◽

Vol 58 (1) ◽

pp. 106-127 ◽

Cited By ~ 10

Author(s):

Christopher Orsborne ◽

Richard Byers

Keyword(s):

Gene Expression ◽

Gene Expression Profiling ◽

Expression Profiling ◽

Diagnosis And Prognosis

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Custom microarray for glycobiologists: considerations for glycosyltransferase gene expression profiling

Biochemical Society Symposium ◽

10.1042/bss0690135 ◽

2002 ◽

Vol 69 ◽

pp. 135-142 ◽

Cited By ~ 12

Author(s):

Elena M. Comelli ◽

Margarida Amado ◽

Steven R. Head ◽

James C. Paulson

Keyword(s):

Gene Expression ◽

Gene Expression Profiling ◽

Expression Profiling ◽

Affymetrix Genechip ◽

Microarray Technology ◽

Gene Arrays ◽

Glycosyltransferase Gene

The development of microarray technology offers the unprecedented possibility of studying the expression of thousands of genes in one experiment. Its exploitation in the glycobiology field will eventually allow the parallel investigation of the expression of many glycosyltransferases, which will ultimately lead to an understanding of the regulation of glycoconjugate synthesis. While numerous gene arrays are available on the market, e.g. the Affymetrix GeneChip® arrays, glycosyltransferases are not adequately represented, which makes comprehensive surveys of their gene expression difficult. This chapter describes the main issues related to the establishment of a custom glycogenes array.

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