NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells

2007 ◽  
Vol 1109 (1) ◽  
pp. 47-57 ◽  
Author(s):  
A. POGGI ◽  
C. PREVOSTO ◽  
M. ZANCOLLI ◽  
P. CANEVALI ◽  
A. MUSSO ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Stromal Cells ◽  
Killer Cell ◽  
Antigen Presenting Cells ◽  
Cell Interaction ◽  
Natural Cytotoxicity ◽  
Antigen Presenting ◽  
Natural Cytotoxicity Receptors ◽  
Self Antigen

scholarly journals Antigen Presenting Cells and Stromal Cells Trigger Human Natural Killer Lymphocytes to Autoreactivity: Evidence for the Involvement of Natural Cytotoxicity Receptors (NCR) and NKG2D

2006 ◽  
Vol 13 (2-4) ◽  
pp. 325-336 ◽  
Author(s):  
Alessandro Poggi ◽  
Maria Raffaella Zocchi
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Stromal Cells ◽  
Viral Infections ◽  
Antigen Presenting Cells ◽  
Cell Interaction ◽  
Natural Cytotoxicity ◽  
Missing Self ◽  
Antigen Presenting ◽  
Natural Cytotoxicity Receptors

Human natural killer (NK) lymphocytes should not damage autologous cells due to the engagement of inhibitory receptor superfamily (IRS) members by HLA-I. Nevertheless, NK cells kill self cells expressing low levels or lacking HLA-I, as it may occur during viral infections (missing-self hypothesis). Herein, we show that human NK cells can be activated upon binding with self antigen presenting cells or stromal cells despite the expression of HLA-I. Indeed, NK cells can kill and produce pro-inflammatory and regulating cytokines as IFN-γ, TNF-α and IL10 during interaction with autologous dendritic cells or bone marrow stromal cells or skin fibroblasts. The killing of antigen presenting and stromal cells is dependent on LFA1/ICAM1 interaction. Further, the natural cytotoxicity receptors (NCR) NKp30 and NKp46 are responsible for the delivery of lethal hit to DC, whereas NKG2D activating receptor, the ligand of the MHC-related molecule MIC-A and the UL16 binding protein, is involved in stromal cell killing. These findings indicate that different activating receptors are involved in cell to self cell interaction. Finally, NK cells can revert the veto effect of stromal cells on mixed lymphocyte reaction further supporting the idea that NK cells may alter the interaction between T lymphocytes and microenvironment leading to autoreactivity.

scholarly journals Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia

2015 ◽  
Vol 5 (1) ◽  
pp. e1041701 ◽  
Author(s):  
Anna Martner ◽  
Anna Rydström ◽  
Rebecca E Riise ◽  
Johan Aurelius ◽  
Harald Anderson ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Myeloid Leukemia ◽  
Killer Cell ◽  
Natural Cytotoxicity ◽  
Natural Cytotoxicity Receptors ◽  
Acute Myeloid

NATURAL KILLER CELL INTERACTION WITH MURINE ALLOGENEIC MHC CLASS I MOLECULES

1995 ◽  
Vol 60 (3) ◽  
pp. 281-286 ◽  
Author(s):  
MARGARITA SALCEDO ◽  
FETTER HOGLUND ◽  
HANS-GUSTAF LJUNGGREN
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Mhc Class I ◽  
Killer Cell ◽  
Cell Interaction ◽  
Class I ◽  
Mhc Class I Molecules

Overexpression of murine fizzy-related (fzr) increases natural killer cell–mediated cell death and suppresses tumor growth

Blood ◽  
2000 ◽  
Vol 96 (1) ◽  
pp. 259-263 ◽  
Author(s):  
Chun-Xiang Wang ◽  
Bernard C. Fisk ◽  
Madhuri Wadehra ◽  
Helen Su ◽  
Jonathan Braun
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Subtractive Hybridization ◽  
Cell Interaction ◽  
Tumor Formation ◽  
Lymphoma Cell ◽  
B Lymphoma ◽  
B Lymphoma Cells ◽  
Murine Homologue

Abstract Fizzy-related (fzr) is a recently identified 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. In this study, the murine homologue of fzr was isolated by suppression subtractive hybridization as a gene with decreased expression during malignant progression of a murine B-lymphoma cell line. Retroviral overexpression of fzr in B-lymphoma cells reduced tumor formation. Those tumors that did arise had diminished or extinguished retroviral Fzr. Surprisingly, fzr overexpression dramatically increased B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity, a host-resistant mechanism for tumor formation in this model system. These findings implicate fzr as a new category of genes suppressing B-cell tumorigenesis and suggest a novel role for fzr in the target cell interaction with NK cells.

Immunological impact of Wharton’s Jelly mesenchymal stromal cells and natural killer cell co-culture

2018 ◽  
Vol 447 (1-2) ◽  
pp. 111-124 ◽  
Author(s):  
Mehdi Najar ◽  
Mohammad Fayyad-Kazan ◽  
Nathalie Meuleman ◽  
Dominique Bron ◽  
Hussein Fayyad-Kazan ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Killer Cell ◽  
Wharton’S Jelly ◽  
Wharton's Jelly
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