scholarly journals Survival Differences in Chinese Versus White Women With Breast Cancer in the United States: A SEER-Based Analysis

2020 ◽  
pp. 1582-1592
Author(s):  
David W. Lim ◽  
Vasily Giannakeas ◽  
Steven A. Narod
Keyword(s):  
Breast Cancer ◽  
United States ◽  
White Women ◽  
Chinese Women ◽  
The United States ◽  
Stage I ◽  
Lymph Node Status ◽  
Breast Cancer Specific Survival ◽  
Cancer Specific Survival ◽  
Matched Design

PURPOSE The affect of race on breast cancer prognosis is not well understood. We compared crude and adjusted breast cancer survival rates of Chinese women versus White women in the United States. METHODS We conducted a cohort study of Chinese and White women with breast cancer diagnosed between 2004 to 2015 in the SEER 18 registries database. We abstracted information on age at diagnosis, tumor size, grade, lymph node status, receptor status, surgical treatment, receipt of radiotherapy and chemotherapy, and death. We compared crude breast cancer–specific mortality between the two ethnic groups. We calculated adjusted hazard ratios (HRs) in a propensity-matched design using the Cox proportional hazards model. P < .05 was considered statistically significant. RESULTS There were 7,553 Chinese women (1.8%) and 414,618 White women (98.2%) with stage I-IV breast cancer in the SEER database. There were small differences in demographics, nodal burden, and clinical stage between Chinese and White women. Ten-year breast cancer–specific survival was 88.8% for Chinese women and 85.6% for White women (HR, 0.73; 95% CI, 0.67 to 0.80; P < .0001). In a propensity-matched analysis among women with stage I–IIIC breast cancer, the HR was 0.71 (95% CI, 0.62 to 0.81; P < .0001). Annual mortality rates in White women exceeded those in Chinese women for the first 9 years after diagnosis. CONCLUSION Chinese women in the United States have superior breast cancer–specific survival compared with White women. The reason for the observed difference is not clear. Differences in demographic and tumor features between Chinese and White women with breast cancer may contribute to the disparity, as may the possibility of intrinsic biologic differences.

scholarly journals Use of neoadjuvant chemotherapy for patients with stage I to III breast cancer in the United States

Cancer ◽  
2015 ◽  
Vol 121 (15) ◽  
pp. 2544-2552 ◽  
Author(s):  
Sarah S. Mougalian ◽  
Pamela R. Soulos ◽  
Brigid K. Killelea ◽  
Donald R. Lannin ◽  
Maysa M. Abu-Khalaf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Neoadjuvant Chemotherapy ◽  
The United States ◽  
Stage I

Breast cancer survival rates among Chinese women born in East Asia and the United States

2005 ◽  
Vol 15 (8) ◽  
pp. 634-634
Author(s):  
S CHUANG ◽  
W CHEN ◽  
M HASHIBE ◽  
G LI ◽  
P GANZ ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
East Asia ◽  
Cancer Survival ◽  
Chinese Women ◽  
Survival Rates ◽  
The United States ◽  
Breast Cancer Survival

Trends in modifiable behaviorally related cancers: Who is affected the most?

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e13531-e13531
Author(s):  
John Chan ◽  
Michelle Ann P. Caesar ◽  
Chloe Chan ◽  
Michael Richardson ◽  
Daniel Stuart Kapp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Physical Inactivity ◽  
White Women ◽  
Postmenopausal Breast Cancer ◽  
The United States ◽  
Racial Groups ◽  
Factors Associated ◽  
Modifiable Factors ◽  
Asian Men

e13531 Background: To examine trends in modifiable behaviorally related cancers among racial groups in the United States. Methods: Data were obtained from the United States Cancer Statistics (USCS) database for all cancers diagnosed between 2001 and 2017. Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. SEER*Stat 8.3.8 and Joinpoint regression program 4.8.0.1 were used to calculate the trends of associated cancers expressed per 100,000. Results: In women, the incidence of all cancers has decreased significantly or remain unchanged for all racial groups in 2017, with the exception of an increase of HPV related cancers in white women (APC = 0.77%, p < 0.001), obesity related cancers in Hispanic women (APC = 0.46%, p < 0.001), and postmenopausal breast cancer in Black and Asian women (APC 0.78%, 1.06%, p < 0.001). The incidence of alcohol, tobacco, obesity, and physical inactivity associated cancer decreased significantly in men for all racial groups in 2017. HPV related cancers increased annually by 3.13% (p < 0.001) in White men and 0.90% in Asian men (p = 0.022). The highest decrease in modifiable factors associated with cancers was in physical inactivity related cancers in black men from the west (APC = -3.79, p < 0.001). The intersection of black race and U.S. region had the highest decreases in all cancers except obesity-related cancers where the intersection of Asian race and Midwest region had the highest decrease. Conclusions: In women, most modifiable factors associated with cancer are decreasing except in obesity related cancers and physical inactivity/obesity related postmenopausal breast cancer. In men, these rates of cancer are decreasing for all racial groups except HPV related cancers in White and Asian men.

scholarly journals Trends in Survival Over the Past Two Decades Among White and Black Patients With Newly Diagnosed Stage IV Breast Cancer

2008 ◽  
Vol 26 (30) ◽  
pp. 4891-4898 ◽  
Author(s):  
Shaheenah Dawood ◽  
Kristine Broglio ◽  
Ana M. Gonzalez-Angulo ◽  
Aman U. Buzdar ◽  
Gabriel N. Hortobagyi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stage Iv ◽  
The United States ◽  
Breast Cancer Specific Survival ◽  
Newly Diagnosed ◽  
Cancer Specific Survival ◽  
Risk Of Death ◽  
Black Patients ◽  
Stage Iv Breast Cancer ◽  
White Patients

Purpose Overall, breast cancer mortality has been declining in the United States, but survival studies of patients with stage IV disease are limited. The aim of this study was to evaluate trends in and factors affecting survival in a large population-based cohort of patients with newly diagnosed stage IV breast cancer. Patients and Methods We searched the Surveillance, Epidemiology, and End Results registry to identify female patients with stage IV breast cancer diagnosed between 1988 and 2003. Patients were divided into three groups according to year of diagnosis (1988 to 1993, 1994 to 1998, and 1999 to 2003). Survival outcomes were estimated by the Kaplan-Meier method, and Cox models were fit to determine the characteristics independently associated with survival. Results We identified 15,438 patients. Median age was 62 years. Median follow-up was 16 months, 18 months, and 11 months in periods 1988 to 1993, 1994 to 1998, and 1999 to 2003, respectively. Median breast cancer–specific survival was 23 months. In the multivariate model, earlier year of diagnosis, grade 3 disease, increasing age, being unmarried, hormone receptor–negative disease, and no surgery were all independently associated with worse overall and breast cancer–specific survival. With each successive year of diagnosis, black patients had an increasingly greater risk of death compared with white patients (hazard ratio, 1.03; 95% CI, 1.00 to 1.06; P = .031). Conclusion The survival of patients with newly diagnosed stage IV breast cancer has modestly improved over time, but these data suggest that the disparity in survival between black and white patients has increased.

scholarly journals Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States

JAMA ◽  
2015 ◽  
Vol 313 (2) ◽  
pp. 165 ◽  
Author(s):  
Javaid Iqbal ◽  
Ophira Ginsburg ◽  
Paula A. Rochon ◽  
Ping Sun ◽  
Steven A. Narod
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Race And Ethnicity ◽  
The United States ◽  
Cancer Stage ◽  
Stage At Diagnosis ◽  
Cancer Specific Survival

Management and Outcome Differences in Supraglottic Cancer Between Ontario, Canada, and the Surveillance, Epidemiology, and End Results Areas of the United States

2003 ◽  
Vol 21 (3) ◽  
pp. 496-505 ◽  
Author(s):  
Patti A. Groome ◽  
Brian O’Sullivan ◽  
Jonathan C. Irish ◽  
Deanna M. Rothwell ◽  
Karleen Schulze ◽  
...  
Keyword(s):  
United States ◽  
Stage Iv ◽  
The United States ◽  
Stage I ◽  
Stage Iii ◽  
Hospital Data ◽  
Cancer Specific Survival ◽  
Supraglottic Cancer ◽  
Stage Iv Disease ◽  
End Results

Purpose: We compared the management and outcome of supraglottic cancer in Ontario, Canada, with that in the Surveillance, Epidemiology, and End Results (SEER) Program areas in the United States. Methods: Electronic, clinical, and hospital data were linked to cancer registry data and supplemented by chart review where necessary. Stage-stratified analyses compared initial treatment and survival in the SEER areas (n = 1,643) with a random sample from Ontario (n = 265). We also compared laryngectomy rates at 3 years in those patients 65 years and older at diagnosis. Results: Radical surgery was more commonly used in SEER, with absolute differences increasing with increasing stage: I/II, 17%; III, 36%; and IV, 45%. The 5-year survival rates were 74% in Ontario and 56% in SEER for stage I/II disease (P = .01), 55.7% in Ontario and 46.8% in SEER for stage III disease (P = .40), and 28.5% in Ontario and 29.1% in SEER for stage IV disease (P = .28). Cancer-specific survival results mirrored the overall survival results with the exception of stage IV disease, for which 34.6% of Ontario patients survived their cancer compared with 38.1% in SEER (P = .10). This stage IV difference was more pronounced when we further controlled for possible cause of death errors by restricting the comparison to patients with a single primary cancer (P = .01). Three-year actuarial laryngectomy rates differed. In stage I/II, these rates were 3% in Ontario compared with 35% in SEER (P < 10−3). In stage III disease, the rates were 30% and 54%, respectively (P = .03), and in stage IV disease they were 33% and 64% (P = .002). Conclusion: There are large differences in the management of supraglottic cancer between the SEER areas of the United States and Ontario. Long-term larynx retention was higher in Ontario, where radiotherapy is widely regarded as the treatment of choice and surgery is reserved for salvage. In stages I to III, survival was similar in the two regions despite the differences in treatment policy. In stage IV, there may be a small survival advantage in the U.S. SEER areas related to the higher use of primary surgery.

Geographic Variation in Mortality From Breast Cancer Among White Women in the United States

1995 ◽  
Vol 87 (24) ◽  
pp. 1846-1853 ◽  
Author(s):  
S. R. Sturgeon ◽  
C. Schairer ◽  
M. Gail ◽  
M. McAdams ◽  
L. A. Brinton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Geographic Variation ◽  
White Women ◽  
The United States
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