Bcl-2 overexpression attenuates apoptosis induction by sulindac sulfide in SW480 human colon cancer cells

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3195-3195
Author(s):  
R. Penington ◽  
F. Sinicrope
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Apoptosis Induction ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sulindac Sulfide ◽  
Human Colon Cancer Cells

scholarly journals Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Mano Horinaka ◽  
Tatsushi Yoshida ◽  
Mitsuhiro Tomosugi ◽  
Shusuke Yasuda ◽  
Yoshihiro Sowa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Human Colon ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sulindac Sulfide ◽  
Myeloid Zinc Finger ◽  
Human Colon Cancer Cells

scholarly journals Apoptotic Cell Death and Inhibition of Wnt/β-Catenin Signaling Pathway in Human Colon Cancer Cells by an Active Fraction (HS7) fromTaiwanofungus camphoratus

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Chi-Tai Yeh ◽  
Chih-Jung Yao ◽  
Jiann-Long Yan ◽  
Shuang-En Chuang ◽  
Liang-Ming Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Dependent Manner ◽  
Apoptosis Induction ◽  
Colon Cancer Cells ◽  
Active Fraction ◽  
Human Colon Cancer ◽  
Taiwanofungus Camphoratus ◽  
Human Colon Cancer Cells

Aberrant activation of Wnt/β-catenin signaling plays an important role in the development of colon cancer. HS7 is an active fraction extracted fromTaiwanofungus camphoratus, which had been widely used as complementary medicine for Taiwan cancer patients in the past decades. In this study, we demonstrated the effects of HS7 on the growth inhibition, apoptosis induction, and Wnt/β-catenin signaling suppression in human colon cancer cells. HS7 significantly inhibited proliferation of HT29, HCT116, and SW480 colon cancer cells in a dose- and time-dependent manner. The apoptosis induction was evidenced by DNA fragmentation and subG1 accumulation, which was associated with increased Bax/Bcl-2 ratio, activation of caspase-3 and cleavage of PARP. By using Tcf-dependent luciferase activity assay, HS7 was found to inhibit theβ-catenin/Tcf transcriptional activities. In addition, HS7 strongly suppressed the binding of Tcf complexes to its DNA-binding site shown in electrophoretic mobility shift assay. This inhibition was further confirmed by the decreased protein levels of Tcf-4 andβ-catenin. Theβ-catenin/Tcf downstream target genes, such assurvivin,c-myc,cyclin D1,MMP7, andMT1-MMPinvolved in apoptosis, invasion, and angiogenesis were also diminished as well. These results indicate thatTaiwanofungus camphoratusmay provide a benefit as integrative medicine for the treatment of colon cancer.

Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some Flavonoids Present in Citrus Plants

2012 ◽  
Vol 75 (11) ◽  
pp. 1896-1902 ◽  
Author(s):  
Olga Wesołowska ◽  
Jerzy Wiśniewski ◽  
Kamila Środa-Pomianek ◽  
Aleksandra Bielawska-Pohl ◽  
Maria Paprocka ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Colon ◽  
Apoptosis Induction ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Resistance Reversal ◽  
Human Colon Cancer Cells

Garcinia Benzophenones Inhibit the Growth of Human Colon Cancer Cells and Synergize with Sulindac Sulfide and Turmeric

2013 ◽  
Vol 13 (10) ◽  
pp. 1540-1550 ◽  
Author(s):  
Linda Einbond ◽  
Jason Mighty ◽  
Ryota Kashiwazaki ◽  
Mario Figueroa ◽  
Filza Jalees ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sulindac Sulfide ◽  
Human Colon Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document