Reduction of Health Status 7 Years After Addition of Chemotherapy to Craniospinal Irradiation for Medulloblastoma: A Follow-Up Study in PNET 3 Trial Survivors—on Behalf of the CCLG (formerly UKCCSG)

2007 ◽  
Vol 25 (27) ◽  
pp. 4239-4245 ◽  
Author(s):  
Kim S. Bull ◽  
Helen A. Spoudeas ◽  
Ghasem Yadegarfar ◽  
Colin R. Kennedy
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Controlled Trial ◽  
Craniospinal Irradiation ◽  
Educational Support ◽  
Patients Âgés ◽  
Follow Up Study ◽  
Medical Induction

Purpose To compare quality of survival after craniospinal irradiation (CSI) alone with survival after CSI plus chemotherapy (CT) for medulloblastoma. Patients and Methods Follow-up study of surviving UK patients with medulloblastoma diagnosed between 1992 and 2000 treated according to one or other treatment arm of the PNET 3 controlled trial. Results Seventy three percent of all 147 eligible patients ages 6.6 to 24.3 years were assessed at a mean of 7.2 years after diagnosis. Health status was significantly poorer in the group treated in the CSI plus CT arm of the trial than in the CSI alone arm, and there were also trends to poorer outcomes for behavior and quality of life scores. The CSI plus CT group were also significantly more restricted physically and needed more therapeutic and educational support. Body mass index, stature, and other endocrine outcomes were similar in the two treatment arms, except for the trend in increased frequency of medical induction of puberty in the CSI plus CT group. Conclusion The addition of CT to CSI for medulloblastoma was associated with a significant decrease in health status. The effect of the addition of other CT regimens to CSI on quality of survival should be evaluated.

scholarly journals The course of health status and (health-related) quality of life following fracture of the lower extremity: a 6-month follow-up study

2015 ◽  
Vol 25 (5) ◽  
pp. 1285-1294 ◽  
Author(s):  
M. A. C. Van Son ◽  
J. De Vries ◽  
J. A. Roukema ◽  
T. Gosens ◽  
M. H. J. Verhofstad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Lower Extremity ◽  
Health Related Quality ◽  
Follow Up Study ◽  
Related Quality ◽  
Health Related

scholarly journals Effect of Nucart VG (Boswellia serrata in combination with veg glucosamine sulphate) in comparison with glucosamine sulphate to improve quality of life of knee osteoarthritis patients: a randomized controlled trial

2021 ◽  
Vol 7 (5) ◽  
pp. 976
Author(s):  
Vijay G. Goni ◽  
Mukesh Mishra ◽  
Sailee Kadam ◽  
Sharat S. Gandhi
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Open Label ◽  
Boswellia Serrata ◽  
Group Randomized Trial ◽  
Glucosamine Sulphate

<p class="abstract"><strong>Background:</strong> <em>Boswellia serrata</em> has been proved to be an effective and safe herb for the treatment of osteoarthritis (OA). This study aims at assessing the synergistic effect of this herb with vegetarian glucosamine sulphate, a nutritional supplement, on knee osteoarthritis using quality of life indicators.</p><p class="abstract"><strong>Methods:</strong> This<strong> </strong>was an open label, parallel group randomized trial of 12-week duration. Sixty-six subjects were equally randomized to two treatment arms: <em>Boswellia serrata</em> extract (600 mg) and glucosamine (750 mg) [Nucart VG]; and glucosamine sulphate (market comparator) 750 mg. Patients were administered 1 tablet twice-a-day post-meal for three months. Efficacy of treatment was measured on primary end-points like EuroQol-5D (EQ-5D) (health status indicator), visual analogue scale (VAS) and Western Ontario and McMaster Universities osteoarthritis index (WOMAC) scale (pain indicators), while safety was measured in terms of vital parameters. Both intention-to-treat (ITT) and per-protocol (PP) analyses were performed for comparing scores between the two groups.<strong></strong></p><p class="abstract"><strong>Results:</strong> The baseline characteristics of patients between two groups were insignificantly different (p&gt;0.05). In ITT analysis, the health status (EQ-5D score) of patients in Nucart VG group improved significantly than the comparator group at follow up 2 (p=0.037) and showed further improvement at follow up 3 (p=0.012). The pain indicators i.e. VAS and WOMAC scores were significantly lower in Nucart VG group right from follow up 1 till follow up 3 (p&lt;0.05). Similar were the observations during PP analysis.</p><p class="abstract"><strong>Conclusions:</strong> Nucart VG is beneficial for the treatment of mild to moderate knee OA, as inferred from the functional and health status assessment.</p>

scholarly journals Psychological Profiles of Chinese Patients With Hemodialysis During the Panic of Coronavirus Disease 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhen-Hua Yang ◽  
Xiao-Ting Pan ◽  
Yu Chen ◽  
Lu Wang ◽  
Qiu-Xin Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Status ◽  
Initial Study ◽  
Hemodialysis Patients ◽  
Dialysis Patients ◽  
Follow Up Study ◽  
The Impact

Background: Hemodialysis patients not only suffer from somatic disorders but are also at high risks of psychiatric problems. Early this year, the outbreak of coronavirus disease 2019 (COVID-19) has caused great panic and anxiety worldwide. The impact of this acute public health event on the psychological status of hemodialysis patients and its relationship with their quality of life have not been fully investigated.Methods: This study comprised two parts. The initial study enrolled maintenance hemodialysis patients treated in Ruijin Hospital for more than 3 months from March to May 2020 during the ongoing COVID-19 pandemic. Patients completed three questionnaires including the Impact of Events Scale–Revised (IES-R), General Health Questionnaire-28 (GHQ-28), and Kidney Disease Quality of Life (KDQOL) Short Form (SF). Follow-up study was performed from December 2020 to January 2021, when the pandemic of COVID-19 has been effectively contained in China. Only patients enrolled in the initial study were approached to participate in the follow-up study.Results: There were 273 maintenance dialysis patients enrolled in the initial study and 247 finished the follow-up study. For the initial study, the estimated prevalence of nonspecific psychiatric morbidity was 45.8% (125/273) by GHQ-28. By IES-R, 53/273 (19.4%) patients presented with total scores above 24 that reflected clinical concerns. We found a significant difference regarding KDQOL scores between patients with different stress response (IES-R) groups (p = 0.026). Our follow-up study showed that KDQOL and SF-36 scores were significantly improved in comparison with those in the initial study (p = 0.006 and p = 0.031, respectively). Though total scores of GHQ-28 and IES-R did not change significantly, some subscales improved with statistical significance. Furthermore, gender, education background, and duration of hemodialysis were three factors that may affect patients' mental health, quality of life, or health status while dialysis duration was the only variable that correlated with those parameters. However, these correlations were combined effects of the COVID-19 pandemic and the dialysis itself.Conclusions: We found a correlation between changes in the mental health status of dialysis patients and changes in their quality of life. These responses were also mediated by patients' psychosocial parameters. Our results urge the necessity of psychotherapeutic interventions for some patients during this event.

Long-term effect of physical activity on menopause-related quality of life – a 4 year follow-up study of a randomized controlled trial

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 139
Author(s):  
Kirsi Mansikkamäki ◽  
Jani Raitanen ◽  
Clas-Håkan Nygård ◽  
Eija Tomás ◽  
Reetta Rutanen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Controlled Trial ◽  
Term Effect ◽  
Follow Up Study ◽  
Randomized Controlled ◽  
Long Term Effect ◽  
Related Quality
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