Barriers to cancer clinical trials (CCT) participation: “We have met the enemy and he is us.”

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6567-6567 ◽  
Author(s):  
R. L. Comis ◽  
D. D. Colaizzi ◽  
J. D. Miller

6567 Background: A web based survey of attitudes and awareness of cancer survivors (Ca. surv) towards CCT was performed from 3–4, 2005. The survey was developed jointly by the Coalition of Cancer Cooperative Groups and Michigan State University (MSU) and executed by MSU and Knowledge Networks (KN). Methods: Ca surv. were obtained from a panel of 40,000 adults through KN based on a US household probablility sample who agree to weekly surveys in exchange for a free MSN box and ISP service. 2,029 panel members reported a cancer diagnosis (dx); 1,788/2,029 (88%) agreed to participate. Results: About 10% of Ca surv. are aware of CCT opportunities at the time of dx. 73% become aware through a physician (ASCO 2006: 6061). Ca surv. were asked to rank the most trusted sources of health care information from a list of 23 categories on a 0 (least) to 10 (most) scale. Physicians scored the highest (8.6) followed by information from the NCI (8.4) and reports from societies of cancer physicians/researchers (8.3). Although not significantly different from each other, all were significantly different from the other 20 sources (p<.05). CCT aware Ca surv. were asked whether the physician discouraged, was neutral or encouraged participation or made a little, moderate or great deal of effort to educate them and find a CCT. Enrollment (%) was directly related (p< 0.01) to the perceived physician involvement as follows: Encouragement: discouraged (0); neutral (16); encouraged (84); Educate: little (22); moderate (41%); great deal (64%); Find trial: little (23); moderate (39); great deal (82%). Of the 90% of Ca surv. who were not aware of CCT, 65% indicated that they would be somewhat or very receptive to enrollment if they had been made aware of an opportunity. Conclusion: Ca surv. are not CCT averse a priori. The physician is the most trusted, primary source of awareness and influence in decisions concerning CCT. Although there are myriad reported barriers to CCT participation, increased CCT participation hinges upon physician commitment and communication; conversely, a lack thereof may be the greatest barrier to increased CCT participation. No significant financial relationships to disclose.

Author(s):  
Snezana Sucurovic

This chapter presents security solutions in integrated patient-centric Web-based health-care information systems, also known as electronic healthcare record (EHCR). Security solutions in several projects have been presented and in particular a solution for EHCR integration from scratch. Implementations of Public key infrastructure, privilege management infrastructure, role based access control and rule based access control in EHCR have been presented. Regarding EHCR integration from scratch architecture and security have been proposed and discussed. This integration is particularly suitable for developing countries with wide spread Internet while at the same time the integration of heterogeneous systems is not needed. The chapter aims at contributing to initiatives for implementation of national and transnational EHCR in security aspect.


2011 ◽  
pp. 1949-1964
Author(s):  
Snezana Sucurovic

This chapter presents security solutions in integrated patient-centric Web-based health-care information systems, also known as electronic healthcare record (EHCR). Security solutions in several projects have been presented and in particular a solution for EHCR integration from scratch. Implementations of Public key infrastructure, privilege management infrastructure, role based access control and rule based access control in EHCR have been presented. Regarding EHCR integration from scratch architecture and security have been proposed and discussed. This integration is particularly suitable for developing countries with wide spread Internet while at the same time the integration of heterogeneous systems is not needed. The chapter aims at contributing to initiatives for implementation of national and transnational EHCR in security aspect.


2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6061-6061 ◽  
Author(s):  
R. L. Comis ◽  
D. Colaizzi ◽  
J. D. Miller

6061 Background: A web-based survey of attitudes and awareness of Ca surv towards CCT was performed from 3–4, 2005. The survey instrument was developed jointly by the Coalition of Cancer Cooperative Groups (CCCG) and Northwestern Univ (NU) and executed by NU and Knowledge Networks (KN). Methods: Ca surv were obtained from a panel of 40,000 adults through KN, based on a US households national probability sample who agree to weekly surveys in exchange for a free WebTV box and ISP service. 2,029 panel members reported a cancer diagnosis. 1,788/2,029 (88%) agreed to participate. Results: Ten-percent of Ca surv were aware that CCT participation was an option. In 73%, a physician was the source of the CCT awareness. Awareness was related to time since diagnosis (< 9 yrs vs > 9yrs); gender (females > males); age (younger > older), and education (baccalaureate vs less). Awareness varied according to cancer type: leukemia, 26%; breast, 15%; lymphoma and lung, 14%; prostate, 12%; melanoma and renal cell, 10%; colorectal and bladder; 6–3%. Awareness was dependent (p < .01) on type of treatment: surgery 5% (n, 880); surgery and RT, 7% (n, 181); RT, 10% (n, 107); chemotherapy, 18% (n, 488). Of the last group, 44% enrolled into CCT; 33% declined and 11% were either ineligible or not offered a CCT. Those who declined were concerned that the new approach might be “less effective” (40%) and about “randomization” (18%). CCT Ca surv reported a high level of satisfaction on a 0 (worst) to 10 (best) scale: “treated with dignity and respect”, 9.6; “overall very positive experience”, 9.3; “recommend to a family member or friend”, 8.8. Conversely, the response to “I felt like a guinea pig” was 1.7. Conclusions: In summary, assessing issues such as awareness, participation and accrual onto CCT must adjust for key demographic, disease and treatment related factors. The CCT experience is valued and appreciated by Ca surv as they move the field forward. No significant financial relationships to disclose.


2010 ◽  
Vol 19 (9-10) ◽  
pp. 1371-1377 ◽  
Author(s):  
Bryan A Weber ◽  
David J Derrico ◽  
Saunjoo L Yoon ◽  
Pamela Sherwill-Navarro

Author(s):  
James C.S. Kim

Bovine respiratory diseases cause serious economic loses and present diagnostic difficulties due to the variety of etiologic agents, predisposing conditions, parasites, viruses, bacteria and mycoplasma, and may be multiple or complicated. Several agents which have been isolated from the abnormal lungs are still the subject of controversy and uncertainty. These include adenoviruses, rhinoviruses, syncytial viruses, herpesviruses, picornaviruses, mycoplasma, chlamydiae and Haemophilus somnus.Previously, we have studied four typical cases of bovine pneumonia obtained from the Michigan State University Veterinary Diagnostic Laboratory to elucidate this complex syndrome by electron microscopy. More recently, additional cases examined reveal electron opaque immune deposits which were demonstrable on the alveolar capillary walls, laminae of alveolar capillaries, subenthothelium and interstitium in four out of 10 cases. In other tissue collected, unlike other previous studies, bacterial organisms have been found in association with acute suppurative bronchopneumonia.


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