Genetic associations with taxane-induced neuropathy by a genome-wide association study (GWAS) in E5103.

In 2015, a genome-wide association study described 59 independent signals that showed strong associations with 85 fasting metabolite concentrations as measured by the Biocrates AbsoluteIDQ p150 kit. However, the human body resides in a nonfasting state for the greater part of the day, and the genetic basis of postprandial metabolite concentrations remains largely unknown. We systematically examined these previously identified genetic associations in postprandial metabolite concentrations after a mixed meal. Of these 85 metabolites, 23 were identified with significant changes after the meal, for which 38 gene-metabolite associations were analyzed. Of these 38 associations, 31 gene-metabolite associations were replicated with postprandial metabolite concentrations. These data indicate that the genetics of fasting and postprandial metabolite levels are significantly overlapping.

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A genome-wide association study finds novel genetic associations with broadly-defined headache in UK Biobank (N = 223,773)

10.1101/217786 ◽

2017 ◽

Author(s):

Weihua Meng ◽

Mark J Adams ◽

Harry L Hebert ◽

Ian J Deary ◽

Andrew M McIntosh ◽

...

Keyword(s):

Association Study ◽

Genome Wide Association Study ◽

Genetic Correlations ◽

Genome Wide Association ◽

Uk Biobank ◽

Genetic Associations ◽

Psychological Traits ◽

Genome Wide ◽

A Genome ◽

The Uk

AbstractHeadache is the most common neurological symptom and a leading cause of years lived with disability. We sought to identify the genetic variants associated with a broadly-defined headache phenotype in 223,773 subjects from the UK Biobank cohort. We defined headache based on a specific question answered by the UK Biobank participants. We performed a genome-wide association study of headache as a single entity, using 74,461 cases and 149,312 controls. We identified 3,343 SNPs which reached the genome-wide significance level of P < 5 × 10−8. The SNPs were located in 28 loci, with the top SNP of rs11172113 in the LRP1 gene having a P value of 4.92 × 10−47. Of the 28 loci, 14 have previously been associated with migraine. Among 14 new loci, rs77804065 with a P value of 5.87 × 10−15 in the LINC02210-CRHR1 gene was the top SNP.Positive relationships (P < 0.001) between multiple brain tissues and genetic associations were identified through tissue expression analysis, whereas no vascular related tissues showed significant relationships. We identified several significant positive genetic correlations between headache and other psychological traits including neuroticism, depressive symptoms, insomnia, and major depressive disorder.Our results suggest that brain function is closely related to broadly-defined headache. In addition, we also found that many psychological traits have genetic correlations with headache.

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Genome-Wide Association Study Reveals Genomic Region Associated with Mite-Recruitment Phenotypes in the Domesticated Grapevine (Vitis vinifera)

Genes ◽

10.3390/genes12071013 ◽

2021 ◽

Vol 12 (7) ◽

pp. 1013

Author(s):

Erika R. LaPlante ◽

Margaret B. Fleming ◽

Zoë Migicovsky ◽

Marjorie Gail Weber

Keyword(s):

Association Study ◽

Genome Wide Association Study ◽

Plant Traits ◽

Leaf Shape ◽

Common Garden ◽

Genome Wide Association ◽

Genetic Associations ◽

Predacious Mites ◽

Genome Wide ◽

A Genome

Indirect defenses are plant phenotypes that reduce damage by attracting natural enemies of plant pests and pathogens to leaves. Despite their economic and ecological importance, few studies have investigated the genetic underpinnings of indirect defense phenotypes. Here, we present a genome-wide association study of five phenotypes previously determined to increase populations of beneficial (fungivorous and predacious) mites on grape leaves (genus Vitis): leaf bristles, leaf hairs, and the size, density, and depth of leaf domatia. Using a common garden genetic panel of 399 V. vinifera cultivars, we tested for genetic associations of these phenotypes using previously obtained genotyping data from the Vitis9kSNP array. We found one single nucleotide polymorphism (SNP) significantly associated with domatia density. This SNP (Chr5:1160194) is near two genes of interest: Importin Alpha Isoform 1 (VIT_205s0077g01440), involved in downy mildew resistance, and GATA Transcription Factor 8 (VIT_205s0077g01450), involved in leaf shape development. Our findings are among the first to examine the genomic regions associated with ecologically important plant traits that facilitate interactions with beneficial mites, and suggest promising candidate genes for breeding and genetic editing to increase naturally occurring predator-based defenses in grapevines.

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A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773)

EBioMedicine ◽

10.1016/j.ebiom.2018.01.023 ◽

2018 ◽

Vol 28 ◽

pp. 180-186 ◽

Cited By ~ 21

Author(s):

Weihua Meng ◽

Mark J. Adams ◽

Harry L. Hebert ◽

Ian J. Deary ◽

Andrew M. McIntosh ◽

...

Keyword(s):

Association Study ◽

Genome Wide Association Study ◽

Genome Wide Association ◽

Uk Biobank ◽

Genetic Associations ◽

Genome Wide ◽

A Genome

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PSIV-16 Genome-wide association study of Rambouillet rams with angular limb deformities

Journal of Animal Science ◽

10.1093/jas/skab235.554 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 301-302

Author(s):

Gabrielle M Becker ◽

Morgan R Stegemiller ◽

Christopher S S Schauer ◽

Whit C C Stewart ◽

Brenda M Murdoch

Keyword(s):

Association Study ◽

Genome Wide Association Study ◽

Principal Component ◽

Genome Wide Association ◽

P Value ◽

Genetic Associations ◽

Genome Wide ◽

A Genome ◽

Increased Risk ◽

Limb Deformities

Abstract Lameness and limb deformities can be detrimental to range and breeding sheep. Growing animals are at an increased risk of angular limb deformities (ALD) and lameness, which adversely affects their mobility, breeding soundness and ultimately longevity. Ram testing allows developing ram lambs from different farms to be evaluated together under a consistent nutritive and environment management system. The aim of this study is to investigate rams from four ram test cohorts (North Dakota State University and University of Wyoming in two consecutive years) for genetic associations with ALD occurrence. In total 131 Rambouillet rams, including 17 ALD-affected and 114 unaffected, were genotyped using AxiomTM Ovine Genotyping Array (50K). A genome-wide association study was conducted using a recessive chi-square model with correction by principal component analysis (eigenstrat). A marker on chromosome eight is significantly (unadjusted P-value= 1.74e-08) associated with the incidence of ALD. This marker is located within the gene; branched chain keto acid dehydrogenase E1 subunit beta (BCKDHB). BCKDHB is associated with mitochondrial membranes and metabolism which is required for effective bone (osteoblast and chondrocytes) formation. It is proposed that altered branched amino acid metabolism in rapidly growing sheep with this genotype may impart risk of limb deformities classified as ALD. Identifying genetic associations with ALD in sheep may help detect animals with a higher propensity for ALD, which would provide producers with additional tools to make informed management and breeding decisions.

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