Surgical, histopathologic, and patient-related factors associated with isolated brain metastases (IBM) in patients with stages I-IIIA non-small cell carcinoma (NSCLC) undergoing surgical resection in comparison with patients developing other distal metastases (ODM).

Abstract Brain metastases from esophageal cancer is rare and the incidence has been reported at approximately 5%. We report a case of brain metastases with repeated bleeding from Esophageal carcinoma. The case is a 76-year-old man. Three years ago he was diagnosed with small cell carcinoma of the esophagus by endoscopic biopsy. Metastasis was found only in the cervical lymph node, but the condition was stable by chemoradiotherapy and no metastases were found throughout the body before 1 month. He was admitted to the hospital because of a sudden convulsion, and CT scan revealed cerebral hemorrhage in the right frontal lobe. We performed conservative treatment, but rebleeding was observed from the same site repeatedly after 1 month and 2 months. Due to the influence of bleeding, it was difficult to distinguish cerebral hemorrhage from brain tumor by contrast MRI. After surgery, the cause of bleeding was diagnosed as metastatic brain tumor of esophageal small cell carcinoma. Postoperative radiation therapy was performed in another hospital, but rebleeding was observed 3 months after the operation. A reoperation was performed at another hospital, and a recurrence of metastatic brain tumor was diagnosed. In the case of highly malignant metastatic brain tumors, it was considered necessary to frequently follow the images.

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A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung

Lung Cancer ◽

10.1016/j.lungcan.2004.02.019 ◽

2004 ◽

Vol 46 (1) ◽

pp. 107-111 ◽

Cited By ~ 67

Author(s):

Mario Guerrieri ◽

Kevin Wong ◽

Gail Ryan ◽

Michael Millward ◽

George Quong ◽

...

Keyword(s):

Brain Metastases ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell ◽

Phase Iii ◽

Palliative Radiation ◽

Phase Iii Study

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Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature

Case Reports in Oncological Medicine ◽

10.1155/2015/847058 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6

Author(s):

Debebe Theodros ◽

C. Rory Goodwin ◽

Genevieve M. Crane ◽

Jason Liauw ◽

Lawrence Kleinberg ◽

...

Keyword(s):

Cell Carcinoma ◽

Surgical Resection ◽

Small Cell Carcinoma ◽

Vestibular Schwannoma ◽

Primary Tumor ◽

Cerebellopontine Angle ◽

Internal Auditory Canal ◽

Small Cell ◽

Poorly Differentiated ◽

Small Intestinal

Extrapulmonary small cell carcinomas (EPSCC) are rare malignancies with poor patient prognoses. We present the case of a 63-year-old male who underwent surgical resection of a poorly differentiated small cell carcinoma, likely from a small intestinal primary tumor that metastasized to the cerebellopontine angle (CPA). A 63-year-old male presented with mild left facial paralysis, hearing loss, and balance instability. MRI revealed a 15 mm mass in the left CPA involving the internal auditory canal consistent with a vestibular schwannoma. Preoperative MRI eight weeks later demonstrated marked enlargement to 35 mm. The patient underwent a suboccipital craniectomy and the mass was grossly different visually and in consistency from a standard vestibular schwannoma. The final pathology revealed a poorly differentiated small cell carcinoma. Postoperative PET scan identified avid uptake in the small intestine suggestive of either a small intestinal primary tumor or additional metastatic disease. The patient underwent whole brain radiation therapy and chemotherapy and at last follow-up demonstrated improvement in his symptoms. Surgical resection and radiotherapy are potential treatment options to improve survival in patients diagnosed with NET brain metastases. We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.

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Brain metastases in small cell carcinoma

JAMA ◽

10.1001/jama.244.18.2048c ◽

1980 ◽

Vol 244 (18) ◽

pp. 2048c-2048

Author(s):

R. E. Burgess

Keyword(s):

Brain Metastases ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell

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Effect of initial resection of small-cell carcinoma of the lung: a review of Southwest Oncology Group Study 7628.

Journal of Clinical Oncology ◽

10.1200/jco.1985.3.7.964 ◽

1985 ◽

Vol 3 (7) ◽

pp. 964-968 ◽

Cited By ~ 35

Author(s):

G G Friess ◽

J D McCracken ◽

M L Troxell ◽

R Pazdur ◽

C A Coltman ◽

...

Keyword(s):

Cell Carcinoma ◽

Survival Time ◽

Surgical Resection ◽

Small Cell Carcinoma ◽

Median Survival ◽

Median Survival Time ◽

Small Cell ◽

Oncology Group ◽

Primary Tumors ◽

Southwest Oncology Group

The role of surgery in small-cell carcinoma of the lung (SCCL) has been recently re-evaluated. We reviewed the records of 262 patients with limited SCCL on Southwest Oncology Group (SWOG) protocol 7628. Fifteen patients were identified who presented after surgical resection (12 lobectomy, three pneumonectomy). All patients were subsequently treated with chemotherapy, radiotherapy +/- immunotherapy (BCG). Median survival time was 10.5 months. Median survival time of patients with initial surgical resection was 25 months (P = .004). Forty-five percent of the surgical patients were alive at two years v 13.7% of the nonsurgical patients (P less than .05). A second subgroup of 33 patients was identified with small primary tumors who did not undergo surgical resection. Median survival time in this group was ten months (P = .03). Site of initial relapse was clearly documented in 142 patients. Fifty-six percent of patients not receiving surgery had initial relapse within the chest compared to 13% of patients undergoing surgery (P = .002). Whether the survival benefit identified was caused by or was incidental to surgical resection of the primary lesion remains to be determined in randomized prospective trials of operable candidates.

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