AccrualNet: A novel approach to addressing clinical trial accruals through a knowledge-based, community of practice platform.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e16621-e16621
Author(s):  
H. Massett ◽  
L. K. Parreco ◽  
R. M. Padberg ◽  
E. Richmond ◽  
D. M. Dilts
2011 ◽  
Vol 7 (6) ◽  
pp. e32-e39 ◽  
Author(s):  
Holly A. Massett ◽  
Linda K. Parreco ◽  
Rose Mary Padberg ◽  
Ellen S. Richmond ◽  
Marie E. Rienzo ◽  
...  

AccrualNet represents a unique, centralized comprehensive-solution platform to systematically capture accrual knowledge for all stages of a clinical trial.


Author(s):  
Gerhard Reisinger ◽  
Philipp Hold ◽  
Wilfried Sihn

AbstractThe global megatrends of digitization and individualization substantially affect manufacturing enterprises. Assembly workers are exposed to increased process complexity resulting in physical and cognitive workload. Worker guidance systems (WGS) are used to overcome this challenge through output of information regarding what should be done, how it should be done and why it should be done. An unsolved scientific challenge in this context is efficient information supply of WGS. Information such as worker’s instruction texts, pictures or 3D representations are created by employees of the work preparation department and transferred to the WGS. Manual information supply is a time-consuming and complex process, which requires a high (non-value-adding) effort as well as comprehensive knowledge in handling 3D CAD modelling and software programming. This paper presents a novel approach to reduce the required manual effort in information supply process. A knowledge-based model is proposed that enables an automated information supply of WGS in smart assembly environment by means of algorithms and self-learning expert systems, which pursues a holistic and consistent approach without media breaks. The automated approach assists employees of work preparation department, which means they can concentrate on their essential core competencies instead of being busy, for example, creating assembly plans, instruction texts or pictures for individual WGS. Finally, the technical implementation as a software-based proof-of-concept demonstrator and sub-sequent integration into the IT environment of TU Wien Pilot Factory Industry 4.0 is outlined.


2019 ◽  
Vol 37 (6) ◽  
pp. 929-951 ◽  
Author(s):  
Laurent Remy ◽  
Dragan Ivanović ◽  
Maria Theodoridou ◽  
Athina Kritsotaki ◽  
Paul Martin ◽  
...  

Purpose The purpose of this paper is to boost multidisciplinary research by the building of an integrated catalogue or research assets metadata. Such an integrated catalogue should enable researchers to solve problems or analyse phenomena that require a view across several scientific domains. Design/methodology/approach There are two main approaches for integrating metadata catalogues provided by different e-science research infrastructures (e-RIs): centralised and distributed. The authors decided to implement a central metadata catalogue that describes, provides access to and records actions on the assets of a number of e-RIs participating in the system. The authors chose the CERIF data model for description of assets available via the integrated catalogue. Analysis of popular metadata formats used in e-RIs has been conducted, and mappings between popular formats and the CERIF data model have been defined using an XML-based tool for description and automatic execution of mappings. Findings An integrated catalogue of research assets metadata has been created. Metadata from e-RIs supporting Dublin Core, ISO 19139, DCAT-AP, EPOS-DCAT-AP, OIL-E and CKAN formats can be integrated into the catalogue. Metadata are stored in CERIF RDF in the integrated catalogue. A web portal for searching this catalogue has been implemented. Research limitations/implications Only five formats are supported at this moment. However, description of mappings between other source formats and the target CERIF format can be defined in the future using the 3M tool, an XML-based tool for describing X3ML mappings that can then be automatically executed on XML metadata records. The approach and best practices described in this paper can thus be applied in future mappings between other metadata formats. Practical implications The integrated catalogue is a part of the eVRE prototype, which is a result of the VRE4EIC H2020 project. Social implications The integrated catalogue should boost the performance of multi-disciplinary research; thus it has the potential to enhance the practice of data science and so contribute to an increasingly knowledge-based society. Originality/value A novel approach for creation of the integrated catalogue has been defined and implemented. The approach includes definition of mappings between various formats. Defined mappings are effective and shareable.


1986 ◽  
Vol 75 (03) ◽  
pp. 142-147 ◽  
Author(s):  
Peter Fisher

AbstractA small number of double-blind, placebo-controlled trials of homœopathic treatment in rheumatological conditions have been carried out. These have used differing methodologies, leading to varying results. This paper describes a novel approach in the treatment of fibrositis, a syndrome which lacks a pathological definition, but is defined solely in terms of its symptomatology.24 patients were prescribed for 3 months, according to indication, one of three homœopathic remedies (Arnica, Bryonia, Rhus tox.), each patient remaining on the same remedy throughout. They were followed monthly on the following parameters: pain, number of tender spots and sleep. An ‘indication score’ was allotted to each prescription. The results were analyzed by non-parametric statistical methods, showing that homœopathy produced a statistically significant improvement, but only when the prescribed remedy was well indicated.


2018 ◽  
Vol 20 (2) ◽  
pp. e72 ◽  
Author(s):  
Estelle Everett ◽  
Brian Kane ◽  
Ashley Yoo ◽  
Adrian Dobs ◽  
Nestoras Mathioudakis

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