Evidence-Based Treatment of Depression in Patients With Cancer

2012 ◽  
Vol 30 (11) ◽  
pp. 1187-1196 ◽  
Author(s):  
Madeline Li ◽  
Peter Fitzgerald ◽  
Gary Rodin
Keyword(s):  
Evidence Base ◽  
Current Evidence ◽  
Future Research ◽  
Research Directions ◽  
Evidence Based Treatment ◽  
Patients With Cancer ◽  
Relative Paucity ◽  
Treatment Of Depression ◽  
Future Research Directions ◽  
Pharmacologic Treatments

Purpose Depression is a common condition in patients with cancer, although there has been a relative paucity of research on the effectiveness of treatment in this population. This review summarizes the psychosocial and pharmacologic treatment of depression in patients with cancer based on a consideration of evidence regarding etiologic factors and treatment outcomes. Methods A review of the evidence base for psychosocial and pharmacologic interventions for depression in patients with cancer was performed, including original studies, systematic reviews, and meta-analytic studies in the literature. Results Recent evidence from randomized controlled trials has demonstrated the efficacy of psychosocial and pharmacologic treatments to alleviate depression in patients with cancer. Further research is needed to establish their relative and combined efficacy and their role in the treatment of depression that is less severe and occurs in association with more advanced disease. First-line recommendations for the treatment of depression in patients with cancer are difficult to derive based on current evidence, because comparative studies have not been conducted to support the superiority of one treatment modality over another in this population. Conclusion Both psychosocial and pharmacologic interventions have been shown to be efficacious in treating depression in cancer, but further research is needed to establish their relative and combined benefit. Future research directions include the development and evaluation of novel interventions targeted to specific biologic and psychosocial risk factors.

scholarly journals Current developments and future directions in respiratory physiotherapy

2020 ◽  
Vol 29 (158) ◽  
pp. 200264
Author(s):  
Antenor Rodrigues ◽  
Gerard Muñoz Castro ◽  
Cristina Jácome ◽  
Daniel Langer ◽  
Selina M. Parry ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Integrated Care ◽  
Respiratory Diseases ◽  
Respiratory Therapy ◽  
Current Evidence ◽  
Future Research ◽  
Future Directions ◽  
Research Directions ◽  
Future Research Directions ◽  
Respiratory Physiotherapy

Respiratory physiotherapists have a key role within the integrated care continuum of patients with respiratory diseases. The current narrative review highlights the profession's diversity, summarises the current evidence and practice, and addresses future research directions in respiratory physiotherapy. Herein, we describe an overview of the areas that respiratory physiotherapists can act in the integrated care of patients with respiratory diseases based on the Harmonised Education in Respiratory Medicine for European Specialists syllabus. In addition, we highlight areas in which further evidence needs to be gathered to confirm the effectiveness of respiratory therapy techniques. Where appropriate, we made recommendations for clinical practice based on current international guidelines.

scholarly journals Should we expect bilingualism to confer cognitive benefits in children with Autism Spectrum Disorders?

2020 ◽  
Author(s):  
Rachael Davis ◽  
Lewis Montgomery ◽  
Hugh Rabagliati ◽  
Antonella Sorace ◽  
Sue Fletcher-Watson
Keyword(s):  
Research Priorities ◽  
Evidence Base ◽  
Autism Spectrum ◽  
Future Research ◽  
High Quality Research ◽  
Research Directions ◽  
Cognitive Benefits ◽  
Future Research Directions ◽  
The Impact

This article examines the ways in which bilingualism influences social and cognitive development and identifies intersections between corresponding aspects of autism, to inform future research directions. Three key domains are identified: social cognition; executive functions; and social-cultural factors. In each case we describe the evidence for the impact of bilingualism in typical development and map this onto what is known about the domain in autism. We examine the methodological quality of the existing literature to make recommendations for future approaches. Results suggest a dearth of high-quality research and lack of consensus. Research priorities include the need for innovative designs to explore potential impacts of bilingualism in order to increase the validity of the evidence base for caregivers and professionals.

scholarly journals The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Hui Wang ◽  
Wei Mu ◽  
Hongcai Shang ◽  
Jia Lin ◽  
Xiang Lei
Keyword(s):  
Animal Experiments ◽  
Herbal Medicines ◽  
Current Evidence ◽  
Future Research ◽  
Research Directions ◽  
Rhizoma Coptidis ◽  
History Of ◽  
Future Research Directions ◽  
Main Component ◽  
Antidiabetic Effects

Rhizoma Coptidis (Huang Lian in Chinese pinyin) is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

scholarly journals Epigenetics and childhood asthma: current evidence and future research directions

Epigenomics ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 415-429 ◽  
Author(s):  
Muhammad T Salam ◽  
Ying Zhang ◽  
Kohinoor Begum
Keyword(s):  
Childhood Asthma ◽  
Current Evidence ◽  
Future Research ◽  
Research Directions ◽  
Future Research Directions

scholarly journals Breast Cancer Risk with Progestin Subdermal Implants: A Challenge in Patients Counseling

2021 ◽  
Vol 12 ◽  
Author(s):  
Ghada Mohammed ◽  
Noha A. Mousa ◽  
Iman M. Talaat ◽  
Haya Ibrahim ◽  
Maha Saber-Ayad
Keyword(s):  
Potential Role ◽  
Clinical Evidence ◽  
Potential Effect ◽  
Current Evidence ◽  
Future Research ◽  
Patient Counseling ◽  
Research Directions ◽  
Future Research Directions ◽  
Subdermal Implants

There is a steady global rise in the use of progestin subdermal implants, where use has increased by more than 20 times in the past two decades. BC risk has been reported with the older progestin only methods such as oral pills, injectables, and intrauterine devices, however, little is known about the risk with subdermal implants. In this review, we aim to update clinicians and researchers on the current evidence to support patient counseling and to inform future research directions. The available evidence of the association between the use of progestin subdermal implants and BC risk is discussed. We provide an overview of the potential role of endogenous progesterone in BC development. The chemical structure and molecular targets of synthetic progestins of relevance are summarized together with the preclinical and clinical evidence on their association with BC risk. We review all studies that investigated the action of the specific progestins included in subdermal implants. As well, we discuss the potential effect of the use of subdermal implants in women at increased BC risk, including carriers of BC susceptibility genetic mutations.

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