Role of Radiation Therapy in the Management of Locally Advanced Pancreatic Cancer

2012 ◽  
Vol 30 (13) ◽  
pp. 1564-1565 ◽  
Author(s):  
Amr Aref ◽  
Richard Berri
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer

A Matter of Timing: Is There a Role for Radiation in Locally Advanced Pancreatic Cancer, and If So, When?

2012 ◽  
pp. 238-242
Author(s):  
Theodore S. Hong ◽  
Jennifer Y. Wo ◽  
Eunice L. Kwak
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Induction Phase ◽  
Future Directions ◽  
Historic Data ◽  
Chemotherapy Patients

Overview: The role of radiation therapy in the management of locally advanced pancreatic cancer is controversial. Despite its localized presentation, locally advanced pancreatic cancer is characterized by high rates of metastases. Historic data have been mixed, and newer studies have called into question the use of radiation therapy. However, it appears that patients more likely to benefit from chemoradiation can be identified with an induction phase of chemotherapy. Data evaluating this approach suggest that approximately 30% of patients will develop metastatic disease within the first 3 to 4 months of chemotherapy. Patients without progression who receive chemoradiation therapy may experience improved survival. Future directions include the validation of this strategy and the integration of biologic agents.

Radiation Therapy in Operable and Locally Advanced Pancreatic Cancer

2010 ◽  
Vol 8 (9) ◽  
pp. 1022-1031 ◽  
Author(s):  
Andrew H. Ko ◽  
Christopher H. Crane
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Metastatic Disease ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Initial Therapy ◽  
Tumor Burden ◽  
Locally Advanced Pancreatic Cancer ◽  
Therapeutic Decision Making

It is well established that the development of distant metastatic disease represents the dominant pattern of tumor recurrence/progression among patients with operable and locally advanced pancreatic cancer. However, the contribution of localized or locoregional tumor burden to pancreatic cancer–associated morbidity and mortality may be underappreciated, and therefore balancing competing considerations of systemic versus local disease control becomes important in therapeutic decision-making. The role of local therapies, particularly radiation therapy, has remained somewhat controversial in this disease context. Several phase II and III trials have sought to address the relative importance and role of radiation in both the localized and locally advanced settings, including the sequencing of this modality relative to systemic therapy and its optimal means of administration. However, differences and limitations in study design have produced mixed results, particularly in terms of the contribution of radiation to overall survival benefit. An emerging paradigm that makes conceptual sense and remains the subject of active investigation is to start with a defined period of systemic treatment, thus limiting radiation to the subset of patients who do not manifest with metastatic disease during initial therapy and are therefore most likely to benefit from local control.

The role of radiotherapy in locally advanced pancreatic cancer

2021 ◽  
pp. 20210044
Author(s):  
Florence Huguet ◽  
Victoire Dabout ◽  
Eleonor Rivin del Campo ◽  
Sébastien Gaujoux ◽  
Jean Baptiste Bachet
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Technical Progress ◽  
Vascular Invasion ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Metastatic Tumour ◽  
Borderline Resectable ◽  
Made In

At diagnosis, about 15% of patients with pancreatic cancer present with a resectable tumour, 50% have a metastatic tumour, and 35% a locally advanced tumour, non-metastatic but unresectable due to vascular invasion, or borderline resectable. Despite the technical progress made in the field of radiation therapy and the improvement of the efficacy of chemotherapy, the prognosis of these patients remains very poor. Recently, the role of radiation therapy in the management of pancreatic cancer has been much debated. This review aims to evaluate the role of radiation therapy for patients with locally advanced tumours.

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