Randomized Controlled Trial of a Cognitive-Behavioral Therapy Plus Hypnosis Intervention to Control Fatigue in Patients Undergoing Radiotherapy for Breast Cancer

Purpose The objective of this study was to test the efficacy of cognitive-behavioral therapy plus hypnosis (CBTH) to control fatigue in patients with breast cancer undergoing radiotherapy. We hypothesized that patients in the CBTH group receiving radiotherapy would have lower levels of fatigue than patients in an attention control group. Patients and Methods Patients (n = 200) were randomly assigned to either the CBTH (n = 100; mean age, 55.59 years) or attention control (n = 100; mean age, 55.97 years) group. Fatigue was measured at four time points (baseline, end of radiotherapy, 4 weeks, and 6 months after radiotherapy). Fatigue was measured using the Functional Assessment of Chronic Illness Therapy (FACIT) –Fatigue subscale and Visual Analog Scales (VASs; Fatigue and Muscle Weakness). Results The CBTH group had significantly lower levels of fatigue (FACIT) at the end of radiotherapy (z, 6.73; P < .001), 4-week follow-up (z, 6.98; P < .001), and 6-month follow-up (z, 7.99; P < .001) assessments. Fatigue VAS scores were significantly lower in the CBTH group at the end of treatment (z, 5.81; P < .001) and at the 6-month follow-up (z, 4.56; P < .001), but not at the 4-week follow-up (P < .07). Muscle Weakness VAS scores were significantly lower in the CBTH group at the end of treatment (z, 9.30; P < .001) and at the 6-month follow-up (z, 3.10; P < .02), but not at the 4-week follow-up (P < .13). Conclusion The results support CBTH as an evidence-based intervention to control fatigue in patients undergoing radiotherapy for breast cancer. CBTH is noninvasive, has no adverse effects, and its beneficial effects persist long after the last intervention session. CBTH seems to be a candidate for future dissemination and implementation.

Download Full-text

RELATED FACTORS TO RELAPSE IN DEPRESSED PATIENTS AFTER COGNITIVE BEHAVIOURAL THERAPY DURING ONE YEAR PROSPECTIVE FOLLOW-UP

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2011.5.2 ◽

2011 ◽

pp. 13-19

Author(s):

Nhu Minh Hang Tran ◽

Huu Cat Nguyen ◽

Dang Doanh Nguyen ◽

Van Luong Ngo ◽

Vu Hoang Nguyen ◽

...

Keyword(s):

Cognitive Behavioral Therapy ◽

Relapse Rate ◽

Behavioral Therapy ◽

Cognitive Behavioral ◽

Control Group ◽

Controlled Clinical Trial ◽

Related Factors ◽

Depressed Patients ◽

One Year

Objectives: To determine factors impact on the relapse in depressed patients treated with Cognitive Behavioral Therapy (CBT) during one year follow-up. Materials and Methods: 80 depressed patients divided into two groups, group 1: included 40 patients treated with CBT; group 2: 40 patients on amitriptyline. Non-randomized controlled clinical trial, opened, longiditual and prospective research. Results and Conclusions: relapse rate after CBT during 1 year follow-up is 10% (compared to 25% in control group), related factors to relapse rate in depression after CBT are age and education. Shared predictors between 2 groups are severity and recurrence of depression. Key words: Depression, relapse, Cognitive Behavioral Therapy (CBT)

Download Full-text

The Efficacy of Transdiagnostic Cognitive Behavioral Therapy on Migraine Headache: A Randomized Clinical Trial

10.21203/rs.3.rs-1143097/v1 ◽

2022 ◽

Author(s):

Forouzandeh Soleimanian-Boroujeni ◽

Negin Badihian ◽

Shervin Badihian ◽

Vahid Shaygannejad ◽

Yousef Gorji

Keyword(s):

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Intervention Group ◽

Cognitive Behavioral ◽

Control Group ◽

Post Intervention ◽

Therapy Termination ◽

Protocol Registration ◽

And Control

Abstract Introduction: Psychological interventions are shown to be effective in migraine, but not utilized routinely yet. We aimed to evaluate the efficacy of transdiagnostic cognitive behavioral therapy (TCBT) on people with migraine (PwM). Method: This study was conducted on 40 PwM aged 20-50 years. We randomly assigned participants to two groups of intervention, receiving 10 sessions of TCBT, and control. Days with headache, headache severity, migraine-related disability and effects on daily life, number of pain-relivers taken for headache, depression, and anxiety were assessed pre-intervention, post-intervention (three-month follow-up), and one-month after TCBT termination (four-month follow-up).Results: Thirty-five participants suffering moderate to severe migraine completed the study (16 and 19 in TCBT and control groups, respectively). TCBT improved all measured items between study time-points (p<0.05) in the intervention group, while such an improvement was not observed in the control group. Between group comparisons revealed superiority of TCBT group compared to the control group in most measured items at three- and four-month follow-ups (p<0.05).Conclusion: Ten sessions of TCBT improved migraine severity, associated disability, anxiety, and depression in PwM, with persistent effects after one month of therapy termination. TCBT is an affordable, practical, and feasible intervention to be utilized for PwM.Protocol registration: The study protocol was registered in clinicaltrial.gov (NCT03701477) prior to enrollment.

Download Full-text

Light Enhanced Cognitive Behavioral Therapy (CBT+) for Insomnia and Fatigue During Chemotherapy for Breast Cancer: A Randomized Controlled Trial

10.1101/2021.03.23.21254147 ◽

2021 ◽

Author(s):

Helena R Bean ◽

Justine Diggens ◽

Maria Ftanou ◽

Marliese Alexander ◽

Lesley Stafford ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Bright Light ◽

Light Therapy ◽

Cognitive Behavioral ◽

Bright Light Therapy ◽

Patient Reported ◽

Insomnia Symptoms

Study Objectives Sleep problems are common during chemotherapy for breast cancer (BC). We evaluated whether combined brief cognitive behavioral and bright light therapy (CBT+) is superior to treatment as usual with relaxation audio (TAU+) for insomnia symptoms and sleep efficiency (primary outcomes). Methods We randomized women receiving intravenous chemotherapy, stratified by tumor stage and insomnia severity index (ISI), to 6-weeks CBT+ or TAU+. CBT+ included one in-person session, one telephone call, seven emails, and 20 minutes bright light each morning. TAU+ comprised usual treatment and two emails with relaxation audio tracks. Patient-reported outcomes were assessed at baseline, midpoint (week 3), post (week 6) and 3-month follow-up. Results Women (N = 101) were randomly assigned to CBT+ or TAU+. Insomnia symptoms declined significantly more from baseline to post with CBT+ versus TAU+ (-5.06 vs -1.93, P = .009; effect size [ES] = .69). At 3-month follow-up, both groups had improved insomnia symptoms but did not differ (ES = .18, P = .56). CBT+ had higher patient-reported sleep efficiency than TAU+ after the start of intervention (P = .05) and more improvement in fatigue (ES = .59, P = .013) and daytime sleep-related impairment (ES = .61, P = .009) from baseline to post. Conclusions CBT+ had a clinically significant impact on insomnia and fatigue with moderate effect sizes. Results support offering cognitive behavioral therapy for insomnia and bright light therapy during chemotherapy for breast cancer to help manage sleep and fatigue. Clinical trial information: Registered with the Australian New Zealand Clinical Trials Registry (http://anzctr.org.au/), Registration Number: ACTRN12618001255279

Download Full-text

Light Enhanced Cognitive Behavioral Therapy (CBT-I+Light) for Insomnia and Fatigue During Chemotherapy for Breast Cancer: A Randomized Controlled Trial

SLEEP ◽

10.1093/sleep/zsab246 ◽

2021 ◽

Author(s):

Helena R Bean ◽

Justine Diggens ◽

Maria Ftanou ◽

Marliese Alexander ◽

Lesley Stafford ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Bright Light ◽

Light Therapy ◽

Cognitive Behavioral ◽

Bright Light Therapy ◽

Patient Reported ◽

Insomnia Symptoms

Abstract Study Objectives Sleep problems are common during chemotherapy for breast cancer (BC). We evaluated whether combined brief cognitive behavioral and bright light therapy (CBT-I+Light) is superior to treatment as usual with relaxation audio (TAU+) for insomnia symptoms and sleep efficiency (primary outcomes). Methods We randomized women receiving intravenous chemotherapy, stratified by tumor stage and insomnia severity index (ISI), to 6-weeks CBT-I+Light or TAU+. CBT-I+Light included one in-person session, one telephone call, seven emails, and 20 minutes bright light each morning. TAU+ comprised usual treatment and two emails with relaxation audio tracks. Patient-reported outcomes were assessed at baseline, midpoint (week 3), post (week 6) and 3-month follow-up. Results Women (N = 101) were randomly assigned to CBT-I+Light or TAU+. The CBT-I+Light group showed significantly greater improvement in insomnia symptoms than the TAU+ group (-5.06 vs -1.93, P = .009; between-group effect size [ES] = .69). At 3-month follow-up, both groups were lower than baseline but did not differ from each other (between-group ES = .18, P = .56). CBT-I+Light had higher patient-reported sleep efficiency than TAU+ immediately after the start of intervention (P = .05) and significantly greater improvement in fatigue (between-group ES = .59, P = .013) and daytime sleep-related impairment (between-group ES = .61, P = .009) than the TAU+ group. Conclusion CBT-I+Light had a clinically significant impact on insomnia and fatigue with moderate effect sizes. Results support offering cognitive behavioral therapy for insomnia and bright light therapy during chemotherapy for breast cancer to help manage sleep and fatigue.

Download Full-text

Therapist-Guided Internet-Based Treatments for Loneliness: A Randomized Controlled Three-Arm Trial Comparing Cognitive Behavioral Therapy and Interpersonal Psychotherapy

Psychotherapy and Psychosomatics ◽

10.1159/000516989 ◽

2021 ◽

pp. 1-8

Author(s):

Anton Käll ◽

Malin Bäck ◽

Camilla Welin ◽

Hanna Åman ◽

Rasmus Bjerkander ◽

...

Keyword(s):

Quality Of Life ◽

Cognitive Behavioral Therapy ◽

Primary Outcome ◽

Behavioral Therapy ◽

Interpersonal Psychotherapy ◽

Cognitive Behavioral ◽

Control Group ◽

Wait List

Introduction: Chronic loneliness has been linked to many adverse outcomes, including mental health problems. Psychological treatment of loneliness can be effective, but the evidence base is limited. Objective: To investigate the efficacy of 2 internet-based interventions based on cognitive behavioral therapy (ICBT) and interpersonal psychotherapy (IIPT) relative to a wait-list control group and each other. Methods: A total of 170 participants were recruited and randomized to either 9 weeks of ICBT (n = 68), IIPT (n = 68), or a wait-list condition (n = 34). The primary outcome was loneliness, measured using the UCLA Loneliness Scale before, during, and after treatment. Secondary measures of psychiatric disorders and quality of life were administered before and after treatment. Follow-up was conducted 4 months after the treatment had ended. Primary outcome data were analyzed using growth curve modeling. Secondary outcomes were analyzed using robust regression models. The trial was preregistered (ClinicalTrials.gov ID: NCT03807154). Results: The ICBT condition had a significantly greater impact on loneliness compared to the wait-list and IIPT conditions. Effect sizes were moderate to large (Cohen d = 0.71) compared to the wait-list and moderate (d = 0.53) compared to IIPT. The IIPT condition did not differ significantly from the wait-list. Both active treatments led to significant increases in quality of life. Only the ICBT group had significantly lower symptoms of depression and generalized anxiety compared to the wait-list group. Treatment gains were maintained but not improved at follow-up. Conclusions: ICBT can be an efficacious option for alleviating loneliness. The IIPT intervention was not as effective.

Download Full-text

Effectiveness of Group Cognitive - Behavioral Therapy on Reducing Depression

International Letters of Social and Humanistic Sciences ◽

10.18052/www.scipress.com/ilshs.43.1 ◽

2014 ◽

Vol 43 ◽

pp. 1-9

Author(s):

Zeinab Khairkhah ◽

Ahmad Borjali ◽

Faramarz Sohrabi

Keyword(s):

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Training Group ◽

Physical Symptoms ◽

Cognitive Behavioral ◽

Control Group ◽

Emotional Symptoms ◽

The City ◽

Experimental Group

The present research was done with the aim of determining the effectiveness of group Cognitive – Behavioral therapy on reducing depression and its subscales (emotional symptoms, cognitive symptoms and physical symptoms) among the wives of the martyrs in the city of Tehran. First, 200 wives of the martyrs were randomly selected from among the wives of the martyrs who had referred to the counseling center of the Foundation of Martyrs and the questionnaire of depression was administered on them. The subjects whose level of depression was higher than the average level were determined and from among them 60 people were randomly chosen and later they were divided into two equal groups and from these two groups, by drawing one group was selected as the experimental and the other was selected as the control group. In the pretest stage, the questionnaire was administered on the subjects and the experimental group was placed under training, i.e. group cognitive-behavioral therapy, while the control group received no such therapy. In the posttest stage, the questionnaire of depression was carried out on both groups and one month later, the follow up stage was administered. Findings revealed that training group cognitive-behavioral therapy was effective on decreasing depression on the wives of the martyrs in Tehran. Findings also indicated depression among the experimental group and in the follow up stage they enjoyed necessary constancy. It is concluded that the group cognitive-behavioral therapy has considerably diminished depression among the wives.

Download Full-text

Internet-Based Cognitive Behavioral Therapy for Adults With ADHD in Outpatient Psychiatric Care

Journal of Attention Disorders ◽

10.1177/1087054714539998 ◽

2016 ◽

Vol 21 (6) ◽

pp. 508-521 ◽

Cited By ~ 24

Author(s):

Richard Pettersson ◽

Staffan Söderström ◽

Kerstin Edlund-Söderström ◽

Kent W. Nilsson

Keyword(s):

Cognitive Behavioral Therapy ◽

Adult Adhd ◽

Behavioral Therapy ◽

Waiting List ◽

Cognitive Behavioral ◽

Future Research ◽

Control Group ◽

Self Help ◽

Significant Difference

Objective: The purpose of the study was to evaluate an Internet-based cognitive behavioral therapy (iCBT) program targeting difficulties and impairments associated with adult ADHD. Method: Forty-five adults diagnosed with ADHD were randomized to either self-help (iCBT self-help format [iCBT-S]), self-help with weekly group sessions (iCBT group-therapy format [iCBT-G]), or a waiting-list control group. Treatment efficacy was measured at pre- and posttreatment and at 6-month follow-up. Results: Intention-to-treat (ITT) analysis showed a significant reduction in ADHD symptoms for the iCBT-S group in comparison with the waiting-list controls at posttreatment, with a between-group effect size of d = 1.07. The result was maintained at 6-month follow-up. No significant difference was found at posttreatment or 6-month follow-up between the iCBT-S and iCBT-G groups. Conclusion: The findings show that a CBT treatment program administered through the Internet can be a promising treatment for adult ADHD. Limitations of the study design and directions for future research are discussed.

Download Full-text

The Effect of an Anxiety-Coping Program for Children Based on Cognitive Behavioral Therapy on 4th Graders’ Anxiety Levels

10.31219/osf.io/mj83g ◽

2021 ◽

Author(s):

Aykut Kul ◽

Zeynep Hamamcı

Keyword(s):

Cognitive Behavioral Therapy ◽

Separation Anxiety ◽

Behavioral Therapy ◽

Child Anxiety ◽

Cognitive Behavioral ◽

Control Group ◽

General Anxiety ◽

Anxiety Levels ◽

Experimental Group

The purpose of this study was to investigate the effects of an anxiety-coping program for children based on cognitive behavioral therapy on children’s anxiety levels. The study was conducted with 12 students in the fourth grade of primary school. Screen for Child Anxiety Related Disorders (SCARED) was during the study for data collection. Students in the experimental group participated in a Cognitive Behavioral Therapy based anxiety coping program consisting of eight sessions. No study was conducted with the students in the control group. A mixed design of 2x3 was used in the study. Follow-up measurement was performed six months after the study was completed. In the analysis of the data, Mann Whitney U test and Friedman test were used. As a result of the analysis, a significant decrease was observed in the general anxiety, general anxiety disorder, separation anxiety and social anxiety levels of the participants in the experiment group after the intervention which continued during the follow-up period. Furthermore there was no statistically significant decrease in panic disorder/somatic symptoms and school phobia levels of the participants in the experimental group. The findings indicated that the anxiety-coping program for children based on cognitive behavioral therapy is effective in terms of decreasing the anxiety levels of children.

Download Full-text

Cognitive Behavioral Therapy Improves Physical Function and Fatigue in Mild and Moderate Chronic Fatigue Syndrome: A Consecutive Randomized Controlled Trial of Standard and Short Interventions

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.580924 ◽

2021 ◽

Vol 12 ◽

Author(s):

Merethe Eide Gotaas ◽

Tore C. Stiles ◽

Johan Håkon Bjørngaard ◽

Petter C. Borchgrevink ◽

Egil A. Fors

Keyword(s):

Cognitive Behavioral Therapy ◽

Physical Function ◽

Behavioral Therapy ◽

Chronic Fatigue ◽

Cognitive Behavioral ◽

Control Group ◽

Post Intervention ◽

Fatigue Syndrome ◽

Sf 36

Objective: To study whether standard cognitive behavioral therapy (CBT) and a shorter, interpersonal oriented cognitive behavioral therapy (I-CBT) can improve physical function and fatigue in patients diagnosed with mild to moderate chronic fatigue syndrome (CFS) in a multidisciplinary fatigue clinic.Design: Consecutively 236 participants 18–62 years old meeting the Centre of Decease Control, CDC 1994 criteria, with a subsample also fulfilling the Canadian criteria for CFS, were randomly allocated to one of three groups. Two intervention groups received either 16 weeks of standard CBT or 8 weeks of I-CBT vs. a waiting-list control group (WLC). Primary outcome was the subscale Physical Function (PF) from SF-36 (0–100). Secondary outcome was amongst others fatigue measured by Chalder Fatigue Questionnaire (CFQ) (0–33). Outcomes were repeatedly measured up to 52 weeks from baseline.Results: The additional effect relative to baseline at post-intervention for SF-36 physical function was 14.2 (95% CI 7.9–20.4 p < 0.001) points higher for standard CBT and 6.8 (0.5–13.2 p = 0.036) points higher for I-CBT compared with the control group. The additional effect relative to baseline at post-intervention for fatigue was 5.9 (95% CI 0.5–10.5 p = 0.03) points lower for standard CBT compared with the control group but did not differ substantially for I-CBT 4.8 (95% CI −0.4 to 9.9 p = 0.07). The positive change in physical function persisted at 1-year follow-up for both treatment groups, and for standard CBT also in fatigue. The two intervention groups did not differ significantly in self-reported physical function and fatigue at the 1-year follow-up. No serious adverse reactions were recorded in any of the groups during the trial period.Interpretation: A 16-week standard, individual CBT intervention improves physical function and fatigue in CFS outpatients with mild to moderate disease. A shorter 8-week I-CBT program improves physical function. Both treatments are safe, and the effect persist 1 year after baseline.Clinical Trial registration:ClinicalTrials.gov, Identifier: NCT00920777, registered June 15, 2009.REK-project number: 4.2008.2586, registered April 2, 2008. Funding: The Liaison Committee for Education, Research and Innovation in Central Norway.

Download Full-text

The Effect of Cognitive-Behavioral Therapy on Depression, Anxiety, and Stress Levels in Iranian Males With Addiction

SAGE Open ◽

10.1177/2158244018824466 ◽

2019 ◽

Vol 9 (1) ◽

pp. 215824401882446

Author(s):

Ghorban Hemati Alamdarloo ◽

Soheila Moradzadeh Khorasani ◽

Mahmoud Najafi ◽

Fatemeh Soosan Jabbari ◽

Setareh Shojaee

Keyword(s):

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Cognitive Behavioral ◽

Control Group ◽

Stress Scale ◽

Stress Levels ◽

Convenience Sampling ◽

And Control ◽

Experimental Group

This study aimed at investigating the effect of cognitive-behavioral therapy on reducing depression, anxiety, and stress levels of Iranian males with addiction. The participants included 24 Iranian males with addiction selected through convenience sampling and randomly assigned to the experimental ( n = 12) and control ( n = 12) groups. Then, Depression Anxiety and Stress Scale was used as the pretest, posttest, and follow-up tests to assess participants’ levels of depression, anxiety, and stress. The experimental group received eight sessions of cognitive-behavioral therapy, while the control group did not. The findings of the study showed that cognitive-behavioral therapy was effective in reducing participants’ levels of depression, anxiety, and stress. Thus, the findings indicate that the cognitive-behavioral therapy reduced the depression, anxiety, and stress of Iranian males with addiction.

Download Full-text