scholarly journals Anxiety and Health-Related Quality of Life Among Patients With Low–Tumor Burden Non-Hodgkin Lymphoma Randomly Assigned to Two Different Rituximab Dosing Regimens: Results From ECOG Trial E4402 (RESORT)

2015 ◽  
Vol 33 (7) ◽  
pp. 740-748 ◽  
Author(s):  
Lynne I. Wagner ◽  
Fengmin Zhao ◽  
Fangxin Hong ◽  
Michael E. Williams ◽  
Randy D. Gascoyne ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coping Style ◽  
Avoidant Coping ◽  
Random Assignment ◽  
Health Related Quality ◽  
End Points ◽  
General Anxiety ◽  
Related Quality ◽  
Health Related

Purpose The purpose of this study was to compare illness-related anxiety among participants in the Rituximab Extended Schedule or Retreatment Trial (RESORT) randomly assigned to maintenance rituximab (MR) versus rituximab re-treatment (RR). A secondary objective was to examine whether the superiority of MR versus RR on anxiety depended on illness-related coping style. Patients and Methods Patients (N = 253) completed patient-reported outcome (PRO) measures at random assignment to MR or RR (baseline); at 3, 6, 12, 24, 36, and 48 months after random assignment; and at rituximab failure. PRO measures assessed illness-related anxiety and coping style, and secondary end points including general anxiety, worry and interference with emotional well-being, depression, and health-related quality of life (HRQoL). Patients were classified as using an active or avoidant illness-related coping style. Independent sample t tests and linear mixed-effects models were used to identify treatment arm differences on PRO end points and differences based on coping style. Results Illness-related anxiety was comparable between treatment arms at all time points (P > .05), regardless of coping style (active or avoidant). Illness-related anxiety and general anxiety significantly decreased over time on both arms. HRQoL scores were relatively stable and did not change significantly from baseline for both arms. An avoidant coping style was associated with significantly higher anxiety (18% and 13% exceeded clinical cutoff points at baseline and 6 months, respectively) and poorer HRQoL compared with an active coping style (P < .001), regardless of treatment arm assignment. Conclusion Surveillance until RR at progression was not associated with increased anxiety compared with MR, regardless of coping style. Avoidant coping was associated with higher anxiety and poorer HRQoL.

scholarly journals Coping style and health-related quality of life in caregivers of epilepsy patients

2011 ◽  
Vol 258 (10) ◽  
pp. 1788-1794 ◽  
Author(s):  
Judith Andel ◽  
Willemien Westerhuis ◽  
Maeike Zijlmans ◽  
Kathelijn Fischer ◽  
Frans S. S. Leijten
Keyword(s):  
Quality Of Life ◽  
Coping Style ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Effect of APF530 on health-related quality of life (QOL) and other chemotherapy-induced nausea and vomiting (CINV) end points: Phase III MAGIC trial.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e21666-e21666 ◽  
Author(s):  
Ian Schnadig ◽  
Eduardo Braun ◽  
Michael Mosier ◽  
Robert B. Geller ◽  
Lee Steven Schwartzberg
Keyword(s):  
Quality Of Life ◽  
Nausea And Vomiting ◽  
Phase Iii ◽  
Health Related Quality ◽  
End Points ◽  
Related Quality ◽  
Health Related

scholarly journals Effect of Neoadjuvant Chemoradiotherapy on Health-Related Quality of Life in Esophageal or Junctional Cancer: Results From the Randomized CROSS Trial

2018 ◽  
Vol 36 (3) ◽  
pp. 268-275 ◽  
Author(s):  
Bo Jan Noordman ◽  
Mathilde G.E. Verdam ◽  
Sjoerd M. Lagarde ◽  
Maarten C.C.M. Hulshof ◽  
Pieter van Hagen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neoadjuvant Chemoradiotherapy ◽  
Health Related Quality ◽  
End Points ◽  
Treatment Groups ◽  
Cohen’S D ◽  
Related Quality ◽  
Health Related ◽  
Cohen's D

Purpose To compare pre-agreed health-related quality of life (HRQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery or surgery alone. Secondary aims were to examine the effect of nCRT on HRQOL before surgery and the effect of surgery on HRQOL. Patients and Methods Patients were randomly assigned to nCRT (carboplatin plus paclitaxel with concurrent 41.4-Gy radiotherapy) followed by surgery or surgery alone. HRQOL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–Core 30 (QLQ-C30) and –Oesophageal Cancer Module (QLQ-OES24) questionnaires pretreatment and at 3, 6, 9, and 12 months postoperatively. The nCRT group also received preoperative questionnaires. Physical functioning (PF; QLQ-C30) and eating problems (EA; QLQ-OES24) were chosen as predefined primary end points. Predefined secondary end points were global QOL (GQOL; QLQ-C30), fatigue (FA; QLQ-C30), and emotional problems (EM; QLQ-OES24). Results A total of 363 patients were analyzed. No statistically significant differences in postoperative HRQOL were found between treatment groups. In the nCRT group, PF, EA, GQOL, FA, and EM scores deteriorated 1 week after nCRT (Cohen’s d: −0.93, P < .001; 0.47, P < .001; −0.84, P < .001; 1.45, P < .001; and 0.32, P = .001, respectively). In both treatment groups, all end points declined 3 months postoperatively compared with baseline (Cohen’s d: −1.00, 0.33, −0.47, −0.34, and 0.33, respectively; all P < .001), followed by a continuous gradual improvement. EA, GQOL, and EM were restored to baseline levels during follow-up, whereas PF and FA remained impaired 1 year postoperatively (Cohen’s d: 0.52 and −0.53, respectively; both P < .001). Conclusion Although HRQOL declined during nCRT, no effect of nCRT was apparent on postoperative HRQOL compared with surgery alone. In addition to the improvement in survival, these findings support the view that nCRT according to the Chemoradiotherapy for Esophageal Cancer Followed by Surgery Study–regimen can be regarded as a standard of care.

Comparison of Health-Related Quality of Life 5 Years After SPIRIT: Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial

2011 ◽  
Vol 29 (4) ◽  
pp. 362-368 ◽  
Author(s):  
Juanita Mary Crook ◽  
Alfonso Gomez-Iturriaga ◽  
Kris Wallace ◽  
Clement Ma ◽  
Sharon Fung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Random Assignment ◽  
Health Related Quality ◽  
Intervention Trial ◽  
Educational Session ◽  
Related Quality ◽  
Health Related ◽  
Interstitial Radiation

Purpose The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual. We report health-related quality of life (HRQOL) at a mean of 5.3 years for 168 trial-eligible men who either chose or were randomly assigned to RP or BT following a multidisciplinary educational session. Patients and Methods After initial lack of accrual, a multidisciplinary educational session was introduced for eligible patients. In all, 263 men attended 47 sessions. Of those, 34 consented to random assignment, 62 chose RP, and 94 chose BT. Five years later, these 190 men underwent HRQOL evaluation by using the cancer-specific 50-item Expanded Prostate Cancer Index Composite, the Short Form 12 Physical Component Score, and Short Form 12 Mental Component Score. Response rate was 88.4%. The Wilcoxon rank sum test was used to compare summary scores between the two interventions. Results Of 168 survey responders, 60.7% had BT (9.5% randomly assigned) and 39.3% had RP (9.5% randomly assigned). Median age was 61.4 years for BT and 59.4 for RP (P = .05). Median follow-up was 5.2 years (range, 3.2 to 6.5 years). For BT versus RP, there was no difference in bowel or hormonal domains, but men treated with BT scored better in urinary (91.8 v 88.1; P = .02) and sexual (52.5 v 39.2; P = .001) domains, and in patient satisfaction (93.6 v 76.9; P < .001). Conclusion Although treatment allocation was random in only 19%, all patients received identical information in a multidisciplinary setting before selecting RP, BT, or random assignment. HRQOL evaluated 3.2 to 6.5 years after treatment showed an advantage for BT in urinary and sexual domains and in patient satisfaction.

scholarly journals Differences in Autonomy and Health-Related Quality of Life between Resilient and Non-Resilient Individuals with Mild Cognitive Impairment

2019 ◽  
Vol 16 (13) ◽  
pp. 2317 ◽  
Author(s):  
Violeta Clement-Carbonell ◽  
Rosario Ferrer-Cascales ◽  
Nicolás Ruiz-Robledillo ◽  
María Rubio-Aparicio ◽  
Irene Portilla-Tamarit ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Activities Of Daily Living ◽  
Coping Style ◽  
Daily Living ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

The dramatic increase in the number of older people with Mild Cognitive Impairment (MCI) entails a serious public health problem. MCI involves different degrees of dependence that has been previously related to a decrease in Health-Related Quality of Life (HRQoL), due to impairment in the performance of activities of daily living. Resilient coping, as an adaptive coping style, could reduce the associated limitations derived by the characteristic deficits of MCI, and hence improve HRQoL. The principal objective of this work was to compare the level of autonomy (measured in terms of independence in the performance of basic (ADL) and instrumental (IADL) activities of daily living), and HRQoL between resilient and non-resilient individuals with MCI. The results showed a positive relationship between resilience, autonomy, and HRQoL. Hence, resilient participants exhibited higher independence in daily living activities and better HRQoL than non-resilient individuals. Mediation analyses confirmed an indirect influence of resilience on HRQoL through the mediation effect of better performance in IADLs. These findings underline the relevance of resilience as a coping style to compensate deficits in daily living in people with MCI. The inclusion of intervention programs, oriented to the promotion of resilience coping for older adults, might increase the autonomy levels in this population, improving their HRQoL.

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