Survival with nivolumab therapy in recurrent/advanced squamous cell head and neck carcinoma. A single center experience.

The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances.

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Long-term survivor of metastatic squamous-cell head and neck carcinoma with occult primary after cetuximab-based chemotherapy: A case report

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i24.7092 ◽

2021 ◽

Vol 9 (24) ◽

pp. 7092-7098

Author(s):

Christina Große-Thie ◽

Claudia Maletzki ◽

Christian Junghanss ◽

Kathie Schmidt

Keyword(s):

Case Report ◽

Head And Neck ◽

Squamous Cell ◽

Head And Neck Carcinoma ◽

Neck Carcinoma ◽

Term Survivor

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Distant metastases in squamous-cell head and neck carcinoma (SHNC) patients who achieved loco-regional control (LRC)

Journal of Clinical Oncology ◽

10.1200/jco.2004.22.14_suppl.5519 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 5519-5519

Author(s):

S. Pernas ◽

X. Leon ◽

A. Lopez-Pousa ◽

M. Quer ◽

C. Orus ◽

...

Keyword(s):

Head And Neck ◽

Squamous Cell ◽

Head And Neck Carcinoma ◽

Distant Metastases ◽

Regional Control ◽

Neck Carcinoma

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PO-0668: Patterns of failure after intensity modulated radiation therapy for squamous cell head and neck carcinoma

Radiotherapy and Oncology ◽

10.1016/s0167-8140(15)30786-6 ◽

2014 ◽

Vol 111 ◽

pp. S8-S9

Author(s):

F. Caparrotti ◽

M. Rouzaud ◽

H. Vees

Keyword(s):

Radiation Therapy ◽

Head And Neck ◽

Squamous Cell ◽

Intensity Modulated Radiation Therapy ◽

Head And Neck Carcinoma ◽

Patterns Of Failure ◽

Intensity Modulated ◽

Neck Carcinoma

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Immunological microenvironment in the clinical outcome of some solid tumors

Russian Journal of Oncology ◽

10.18821/1028-9984-2015-21-1-55-59 ◽

2016 ◽

Vol 21 (1-2) ◽

pp. 55-59

Author(s):

G. M Manikhas ◽

Svetlana I. Kutukova ◽

N. P Beliak ◽

G. A Raskin ◽

A. I Yaremenko ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Clinical Outcome ◽

Cell Carcinoma ◽

Head And Neck ◽

Solid Tumors ◽

Squamous Cell ◽

Head And Neck Carcinoma ◽

Regional Lymph Nodes ◽

Neck Carcinoma ◽

Colorectal Adenocarcinomas

In our clinical research we studied levels of neutrophils, eosinophils and CD8 T-lymphocytes in stroma and microenvironment of the gastric and colorectal adenocarcinomas, head and neck squamous cell carcinomas (33 patients: 15 with adenocarcinoma and 18 - with head and neck carcinoma). In gastric or colorectal adenocarcinoma expression of neutrophils directly correlates with regional lymph nodes involving, expression of CD8 has inversely correlation with differentiation of the tumor. In head and neck squamous cell carcinoma neutrophils expression inversely correlates with keratinization, CD8 expression has inversely correlation with the size of primary tumor and stage, and has direct correlation with keratinization. This study allows to draw a conclusion about heterogeneity of solid tumors depending on immunology of microenvironment, moreover squamous cell carcinoma of head and neck is more “immunocompetent” structure. Correlation analysis revealed prognostic and predictive value of immunological microenvironment, because showed impact of expression of CD8, neutrophils and eosinophils on clinical outcome of gastric and colorectal adenocarcinomas and squamous cell carcinoma of head and neck.

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