Comparison of the mutation profile between pancreatic head/neck and body/tail cancers.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15752-e15752 ◽  
Author(s):  
Junliang Lu ◽  
Zhiyong Liang ◽  
Huanwen M. Wu ◽  
Junyi Pang ◽  
Xiaolong Liang ◽  
...  
Keyword(s):  
Protein Tyrosine Kinase ◽  
Pancreatic Head ◽  
Clinicopathological Characteristics ◽  
The Body ◽  
Receptor Protein ◽  
Protein Amino Acid ◽  
Kras Mutations ◽  
Pancreatic Body ◽  
Mutation Profile ◽  
Head Neck

e15752 Background: Carcinomas in the pancreatic head/neck and body/tail represent different clinicopathological characteristics, but little is known about the underlying genetic mechanisms. The present study aims to explore the differences in mutation profile between pancreatic head and body/tail cancers. Methods: Fifty-four patients were retrospectively enrolled in the present study. DNA was purified from qualified formalin-fixed, paraffin-embedded tissue blocks of the tumor and corresponding adjacent normal tissue and subjected to target-capture next generation sequencing (TGS). Somatic mutations were identified, which further underwent gene ontology (GO) and KEGG pathway analysis. Results: The most frequently mutated genes in carcinomas of the pancreatic head were KRAS (61.3%), TP53(38.7%), and CDKN2A (16.1%), while that of the pancreatic body/tail were KRAS (95.7%), TP53(87%), CDKN2A (26.1%), and ARID1A (26.1%). The prevalence of TP53 and KRAS mutations in pancreatic head and body/tail cancers were significantly different from each other (p = 0.0006 and p = 0.0037, respectively). Pancreatic head/neck cancers also preserved a broader KRAS mutation spectrum than their counterparts of the body/tail. Pathway analyses revealed that mutations in cancer of pancreatic head/neck were enriched for genes involved in the protein amino acid phosphorylation, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway, and phosphorylation pathways, while cancers of the pancreatic body/tail were enriched for genes involved in colorectal cancers. Conclusions: Cancer of the pancreatic head/neck and body/tail have distinct mutation profiles.

scholarly journals Into which Region Should a Prophylactic Pancreatic Stent Be Inserted? A Propensity Score Matching Analysis

2020 ◽  
Author(s):  
Mitsuru Sugimoto ◽  
Tadayuki Takagi ◽  
Rei Suzuki ◽  
Naoki Konno ◽  
Hiroyuki Asama ◽  
...  
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Past History ◽  
Pancreatic Head ◽  
Patient Characteristics ◽  
The Body ◽  
Head Group ◽  
Stent Insertion ◽  
Pancreatic Stent ◽  
Pancreatic Body

Background and Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is an important procedure for the diagnosis and treatment of pancreaticobiliary diseases. However, post-ERCP pancreatitis (PEP) is sometimes a mortal adverse event. Though pancreatic stent (PS) insertion has proven to be a useful prophylaxis for PEP in several past reports, the region of the pancreas into which the PS should be inserted is unknown. Therefore, this study investigated where a prophylactic PS for PEP should be inserted. Methods: In this retrospective study, we targeted 282 patients without past history of abdominal surgery and who underwent initial ERCP and insertion of prophylactic PS to prevent PEP between January 2007 and April 2019. Patients with PS insertion to the pancreatic head (head group) were compared with patients with PS insertion into the pancreatic body or tail (body/tail group) using propensity score matching for patient characteristics, ERCP procedures, and post-ERCP adverse events. Results: After propensity score matching and removing the cases with the PS passing spontaneously for ERCP procedures, 52 head group patients and 54 body/tail group patients were selected. The PEP rate was significantly higher in the head group than in the body/tail group (9.6% vs. 0%, p=0.026). Conclusion: Pancreatic stent insertion in the pancreatic body/tail was more effective for preventing PEP than PS insertion in the pancreatic head.

scholarly journals Comparative Bioinformatical Analysis of Pancreatic Head Cancer and Pancreatic Body/Tail Cancer

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S54
Author(s):  
L. Yin ◽  
L. Xiao ◽  
Y. Gao ◽  
G. Wang ◽  
H. Gao ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Pancreatic Body ◽  
Bioinformatical Analysis

scholarly journals Clinicopathological characteristics and mutation profile of BRAF and NRAS mutation in cutaneous melanomas in the Western Turkish population

2018 ◽  
Vol 48 (5) ◽  
pp. 973-979 ◽  
Author(s):  
Mustafa Kürşat EVRENOS ◽  
Peyker TEMİZ ◽  
Fethi Sırrı ÇAM ◽  
Murat YAMAN ◽  
Levent YOLERİ ◽  
...  
Keyword(s):  
Turkish Population ◽  
Clinicopathological Characteristics ◽  
Nras Mutation ◽  
Mutation Profile

scholarly journals Cervical intradural extramedullay vascular schwannoma in a thirty eight year old male

2019 ◽  
Vol 6 (7) ◽  
pp. 2634
Author(s):  
Shipra Singhal ◽  
Sufian Zaheer ◽  
Rashmi Arora
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Neck Region ◽  
The Body ◽  
Vascular Changes ◽  
Vascular Tissues ◽  
Clinical Presentations ◽  
Cervical Swelling ◽  
Head Neck

Schwannomas are benign peripheral nerve sheet tumours that may arise almost anywhere in the body but are commonly seen in the head, neck region and in the extremities. They may be associated with variable clinical presentations depending on their location. The peripheral nerves are closely related to vascular tissues morphologically and physiologically and therefore schwannomas may be associated with vascular changes like vascular hyperplasia and vascular dilation. Here authors represent one such case where a 38-year-old patient presented with a cervical swelling which on histopathology was diagnosed as vascular schwannoma.

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