Antimutagenic Effect of Ayurvedic Therapies

2003 ◽  
pp. 255-271 ◽  
Author(s):  
Satwinderjeet Kaur
Keyword(s):  
Antimutagenic Effect

Estimation of the genetic activity of epinephrine hydrotartrate on the model of erythrocytes in peripheral blood in mice

2021 ◽  
Vol 1 (2) ◽  
pp. 6-10
Author(s):  
M. Ya. Ibragimova ◽  
◽  
S. Yu. Zaytsev ◽  
V. V. Semenov ◽  
◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Genetic Effects ◽  
Receptor Ligand ◽  
Antimutagenic Effect ◽  
Genetic Activity ◽  
Ad Libitum ◽  
And Control ◽  
Β Adrenergic Receptors

The aim of the study was to evaluate the genetic activity of erythrocytes in peripheral on the model of peripheral blood erythrocytes in mice. The studies were carried out on mice (males) of the C 57B4/6 line weighing 20 g (1,5–2 months of age). For each experimental and control variant, six males were taken. The animals were kept in vivarium conditions according to international criteria for rinofix bedding, food and water ad libitum. When determining the genetic effects, the adrenergic receptor ligand was injected subcutaneously once. After 8 hours, a mutation inducer, an alkylating drug, cyclophosphamide, was injected intraperitoneally at a dose of 30 mg/kg. Before the end of the experiment in 2,5 hour, mice were injected intraperitoneally with 2.5 mg/kg of colchicine. 24 hours after injection, the animals were euthanized by delongation. The number of erythrocytes with micronuclei was counted from 2000 analyzed cells. The greatest antimutagenic effect (87,5%) of epinephrine hydrotartrate, a stimulator of α- and β-adrenergic receptors, was found at doses of 5 and 0,5 mg/kg.

Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts againstN-Nitrosamines Evaluated by the Ames Test

1999 ◽  
Vol 47 (8) ◽  
pp. 3257-3264 ◽  
Author(s):  
Youssef Ikken ◽  
Paloma Morales ◽  
Adrián Martínez ◽  
María L. Marín ◽  
Ana Isabel Haza ◽  
...  
Keyword(s):  
Ames Test ◽  
Fruit And Vegetable ◽  
Antimutagenic Effect ◽  
Ethanolic Extracts

Comparison of Antimutagenic Effect of Various Tea Extracts (Green, Oolong, Pouchong, and Black Tea)

1994 ◽  
Vol 57 (1) ◽  
pp. 54-58 ◽  
Author(s):  
GOW-CHIN YEN ◽  
HUI-YIN CHEN
Keyword(s):  
Salmonella Typhimurium ◽  
Green Tea ◽  
Aflatoxin B1 ◽  
Black Tea ◽  
Inhibitory Effect ◽  
Manufacturing Processes ◽  
Antimutagenic Effect ◽  
Oolong Tea ◽  
Tea Extract

The antimutagenic effects of various tea extracts prepared from nonfermented tea (green tea), semifermented tea (oolong tea and pouchong tea), and fermented tea (black tea) were investigated by Salmonella/microsome assay. No mutagenicity or toxicity in Salmonella typhimurium TA98 and TA100 was observed with any tea extract. The tea extracts markedly inhibited the mutagenicity of 2-amino-3-methylimidazo(4,5-f)quinoline, 3-amino-1,4-dimethyl-5H-pyridol(4,3-b)indole,2-amino-6-methyldipyrido(l,2-a:3′,2′-d)imidazole, benzo[a]pyrene, and aflatoxin B1 toward S. typhimurium TA98 and TA100 in the presence of S9 mixture, especially those of oolong and pouchong teas inhibited over 90% mutagenicity of these five mutagens at the dosage of 1 mg per plate. Among four tea extracts, black tea exhibited the weakest inhibitory effect on mutagenicity of these five mutagens. The mutagenicity of 4-nitroquinoline-N-oxide, a direct mutagen, was not inhibited by black and oolong tea extracts to S. typhimurium TA98 in the absence of S9 mixture but was increased by the tea extracts at the dose of 1 mg per plate to S. typhimurium TA100. As the antimutagenic effect of semifermented tea was stronger than nonfermented and fermented teas, some antimutagenic substances might be formed during manufacturing processes of tea.

Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process

2001 ◽  
Vol 496 (1-2) ◽  
pp. 39-45 ◽  
Author(s):  
Patricia Ramirez-Victoria ◽  
Judith Guzman-Rincon ◽  
J.J. Espinosa-Aguirre ◽  
Susana Murillo-Romero
Keyword(s):  
Green Pepper ◽  
Antimutagenic Effect ◽  
Capsicum Spp

Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng

2006 ◽  
Vol 44 (4) ◽  
pp. 517-521 ◽  
Author(s):  
Tatiana Ivanova ◽  
Youngsoo Han ◽  
Hyeog-Jin Son ◽  
Yeon-Sook Yun ◽  
Jie-Young Song
Keyword(s):  
Panax Ginseng ◽  
Antimutagenic Effect

Antimutagenic effect of Lentinula edodes (BERK.) Pegler mushroom and possible variation among lineages

2003 ◽  
Vol 41 (4) ◽  
pp. 555-560 ◽  
Author(s):  
M.M Sugui ◽  
P.L Alves de Lima ◽  
R.D Delmanto ◽  
A.F da Eira ◽  
D.M.F Salvadori ◽  
...  
Keyword(s):  
Lentinula Edodes ◽  
Antimutagenic Effect

scholarly journals Antimutagenic effect of epigallocatechin gallate and its effect on the immune response in mice

2011 ◽  
Vol 24 (No. 4) ◽  
pp. 180-192 ◽  
Author(s):  
P. Šmerák ◽  
H. Šestáková ◽  
Z. Polívková ◽  
R. Štětina ◽  
M. Langová ◽  
...  
Keyword(s):  
Green Tea ◽  
Ames Test ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Epigallocatechin Gallate ◽  
Antimutagenic Activity ◽  
Dna Breaks ◽  
Colon Cells ◽  
Antimutagenic Effect ◽  
Aflatoxin B

Green tea is the second-most consumed beverage in the world (water is the first one) and has been used medicinally for centuries in Indiaand China. The active substances in the green tea are polyphenols (catechins) and flavonols which possess a potent antioxidant activity. Epigallocatechin gallate (EGCG) is one of the four major green tea catechins. Using the Ames test, micronucleus test, comet assay, chemiluminescence test, and blastic transformation test, we examined the antimutagenic effects of chemoprotective substance epigallocatechin gallate (EGCG) in the pure form on the mutagenicity induced by three reference mutagens: aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), 2-amino-3-methylimidazo [4,5-f] qui-noline (IQ), and N-nitroso-N-methylurea (MNU), and the effect of EGCG on the immunosuppression caused by these mutagens. Using the Ames test the dose dependent antimutagenic activity of EGCG was proved against indirect mutagens AFB<sub>1</sub> and IQ, but not against the direct mutagen MNU. In the micronucleus test, EGCG had antimutagenic effect upon all three mutagens. EGCG decreased the level of DNA breaks induced by AFB<sub>1</sub> in bone marrow cells and colon epithelium, and the level of DNA breaks induced by MNU in colon cells to the level found in control. The reparatory effect of EGCG on immunosupression induced by all three carcinogenic compounds was proved using chemiluminescence and blastic trasformation tests. &nbsp;

Sign in / Sign up

Export Citation Format

Share Document