Relationship between hypertensive cardiac and extracardiac target organ damage

2003 ◽  
pp. 239-248
Keyword(s):  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

Demographic and Clinical Characteristics of Hypertensive and/or Diabetic Patients with Target Organ Damage in the Lebanese Population

2020 ◽  
Vol 04 (06) ◽  
Author(s):  
Jeannot Kekedjian ◽  
Raymond Challita ◽  
Mikael Abi Abdallah ◽  
Roland Asmar ◽  
Mirna N Chahine
Keyword(s):  
Clinical Characteristics ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Diabetic Patients ◽  
Lebanese Population

Inflammation and Target Organ Damage in Hypertension With or Without Metabolic Syndrome

2005 ◽  
Vol 12 (3) ◽  
pp. 175
Author(s):  
A. Ferrucci ◽  
S. Sciarretta ◽  
V. Venturelli ◽  
G. M. Ciavarella ◽  
P. De Paolis ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

Ambulatory Blood Pressure, Target Organ Damage and Left Atrial Size in Never Treated Essential Hypertensives

2005 ◽  
Vol 12 (3) ◽  
pp. 156
Author(s):  
S. Meani ◽  
C. Cuspidi ◽  
C. Valerio ◽  
V. Fusi ◽  
E. Catini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Left Atrial ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Blood Pressure Target ◽  
Left Atrial Size ◽  
Atrial Size

Nocturnal Hypertension, Nondipping Phenomenon and Target Organ Damage in Obstructive Sleep Apnea Patients - The Bad and the Worse

2015 ◽  
Vol 10 (3) ◽  
pp. 182-188 ◽  
Author(s):  
Radostina Vlaeva Cherneva ◽  
Ognian Borisov Georgiev ◽  
Daniela Stoichkova Petrova ◽  
Emil Ivanov Manov ◽  
Dinko Georgiev Valev ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Nocturnal Hypertension ◽  
Obstructive Sleep

scholarly journals Effects of irbesartan on phenotypic alterations in monocytes and the inflammatory status of hypertensive patients with left ventricular hypertrophy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jingsi Zhang ◽  
Lina Yang ◽  
Yanchun Ding
Keyword(s):  
Ventricular Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Hypertensive Patients ◽  
Inflammatory Status ◽  
Tnf Α

Abstract Background Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of hypertension and the resulting target organ damage. In this study, we observed alterations in the monocyte phenotype and inflammatory state of hypertensive patients with left ventricular hypertrophy (LVH) and studied the effects of irbesartan in these patients. This study might reveal a novel mechanism by which irbesartan alleviates LVH, and it could provide new targets for the prevention and treatment of hypertensive target organ damage. Methods CD163 and CD206 expression on monocytes and IL-10 and TNF-α levels in the serum of hypertensive patients with or without LVH and of healthy volunteers were detected. Furthermore, we treated monocytes from the LVH group with different concentrations of irbesartan, and then, CD163, CD206, IL-10 and TNF-α expression was detected. Results We found, for the first time, that the expression of CD163, CD206 and IL-10 in the LVH group was lower than that in the non-LVH group and healthy control group, but the TNF-α level in the LVH group was significantly higher. Irbesartan upregulated the expression of CD163 and CD206 in hypertensive patients with LVH in a concentration-dependent manner. Irbesartan also increased the expression of IL-10 and inhibited the expression of TNF-α in monocyte culture supernatants in a concentration-dependent manner. Conclusions Our data suggest that inflammation was activated in hypertensive patients with LVH and that the monocyte phenotype was mainly proinflammatory. The expression of proinflammatory factors increased while the expression of anti-inflammatory factors decreased. Irbesartan could alter the monocyte phenotype and inflammatory status in hypertensive patients with LVH. This previously unknown mechanism may explain how irbesartan alleviates LVH. Trail registration The study protocols were approved by the Ethical Committee of the Second Affiliated Hospital of Dalian Medical University. Each patient signed the informed consent form.

scholarly journals Aldosterone: Yet Another Path to Blood Pressure Variability and Target Organ Damage

2015 ◽  
Vol 17 (8) ◽  
pp. 609-610
Author(s):  
Brian S. Decker ◽  
Howard J. Pratt
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

DAILY VARIABILITY OF ARTERIAL STIFFNESS INDEX IN RELATION TO TARGET ORGAN DAMAGE AND SEVERITY OF ARTERIAL HYPERTENSION

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e179
Author(s):  
A. Merezhanova ◽  
E. Tarlovskaya ◽  
K. Mazalov ◽  
M. Mazalova ◽  
N. Kamardina ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Arterial Hypertension ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Stiffness Index ◽  
Daily Variability ◽  
Arterial Stiffness Index
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