Handbook of Pharmaceutical Granulation Technology

2021 ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 33-37
Author(s):  
O. Karunskyi ◽  
G. I. Kotets ◽  
M. M. Madani

The materials of the article present data on research on the chemical, mineral-vitamin composition and nutritional value of a new feed additive from citrus pomace. The article presents the results of research on the technological line of granulation of citrus waste, established the optimal composition for granulation of citrus feed additives: sunflower meal - 20%, molasses - 5% and 75% of citrus fruits.Their chemical composition was studied, the gross content of proteins, fats, assimilated carbohydrates, including simple sugars, was determined, and the efficiency of use in the diets of farm animals was determined. The positive influence of citrus waste granulation technology has been established, which allows to obtain high-quality granules. Chemical analysis of citrus granules showed that 100 g contains: protein - 6.15 g, fat - 0.99 g, carbohydrates - 21.8 g, of which simple sugars 14 g, the energy value of this feed additive - Kcal (kJ) - 120.7 (505.7).The possibility of preparation of feed additives in the form of granules is revealed, which allows to avoid selfsorting of components and overdose of microelements and to improve the consumption of feed ingredients. The ability to prepare feed additives in the form of granules avoids self-sorting of components and overdose of micronutrients and improve the consumption of feed ingredients. The results of zootechnical researches, structure and nutritional value of average daily rations with use of citrus pomace are resulted.It was found that the introduction into the diet of dairy cows feed additives from citrus pomace during stable lactation increases the average daily expectations by 1.8 kg or 15.5%, feed costs for milk production containing 4 fat were 0.97-0, 98 feed units. When using a feed additive from citrus pomace, the nutritional value of the diet is improved due to the ratio of sugar - protein (0.62: 1 vs. 0.8: 1.2).


2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Rajat Radhakrishna Rao ◽  
Abhijeet Pandey ◽  
Aswathi R. Hegde ◽  
Vijay Induvadan Kulkarni ◽  
Chetan Chincholi ◽  
...  

AbstractIn order to be at pace with the market requirements of solid dosage forms and regulatory standards, a transformation towards systematic processing using continuous manufacturing (CM) and automated model-based control is being thought through for its fundamental advantages over conventional batch manufacturing. CM eliminates the key gaps through the integration of various processes while preserving quality attributes via the use of process analytical technology (PAT). The twin screw extruder (TSE) is one such equipment adopted by the pharmaceutical industry as a substitute for the traditional batch granulation process. Various types of granulation techniques using twin screw extrusion technology have been explored in the article. Furthermore, individual components of a TSE and their conjugation with PAT tools and the advancements and applications in the field of nutraceuticals and nanotechnology have also been discussed. Thus, the future of granulation lies on the shoulders of continuous TSE, where it can be coupled with computational mathematical studies to mitigate its complications.


2010 ◽  
Vol 44 (4) ◽  
pp. 213-215 ◽  
Author(s):  
S. A. Minina ◽  
M. G. Ozhigova

2018 ◽  
Vol 34 ◽  
pp. 02022
Author(s):  
Azlina Mat Saad ◽  
Farrah Aini Dahalan ◽  
Naimah Ibrahim ◽  
Sara Yasina Yusuf ◽  
Siti Aqlima Ahmad ◽  
...  

Aerobic granulation technology is applied to treat domestic and industrial wastewater. The Aerobic granular sludge (AGS) cultivated has strong properties that appears to be denser and compact in physiological structure compared to the conventional activated sludge. It offers rapid settling for solid:liquid separation in wastewater treatment. Aerobic granules were developed using sequencing batch reactor (SBR) with intermittent aerobic – anaerobic mode with 8 cycles in 24 hr. This study examined the settling velocity performance of cultivated aerobic granular sludge (AGS) and aerobic granular sludge molasses (AGSM). The elemental composition in both AGS and AGSM were determined using X-ray fluorescence (XRF). The results showed that AGSM has higher settling velocity 30.5 m/h compared to AGS.


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