Functional Classes and Chemicals/Substances in these Classes that have Caused Allergic Cosmetic Dermatitis

2021 ◽  
pp. 1371-1395
Author(s):  
Anton C. de Groot
2017 ◽  
Vol 2 (3) ◽  

For almost 20 years after the end of World War II, many Japanese women were challenged by a dark secondary hyper pigmentation on their faces. The causation of this condition was unknown and incurable at the time. However this symptom became curable after a number of new cosmetic allergens were discovered through patch tests and as an aftermath, various cosmetics and soaps that eliminated all these allergens were put into production to be used exclusively for these patients. An international research project conducted by seven countries was set out to find out the new allergens and discover non-allergic cosmetic materials. Due to these efforts, two disastrous cosmetic primary sensitizers were banned and this helped to decrease allergic cosmetic dermatitis. Towards the end of the 20th century, the rate of positives among cosmetic sensitizers decreased to levels of 5% - 8% and have since maintained its rates into the 21th century. Currently, metal ions such as the likes of nickel have been identified as being the most common allergens found in cosmetics and cosmetic instruments. They often produce rosacea-like facial dermatitis and therefore allergen controlled soaps and cosmetics have been proved to be useful in recovering normal skin conditions.


Author(s):  
Ruohan Li ◽  
Jorge A. Prozzi

The objective of this study is to evaluate the field variability of jointed concrete pavement (JCP) faulting and its effects on pavement performance. The standard deviation of faulting along both the longitudinal and transverse directions are calculated. Based on these, the overall variability is determined, and the required sample sizes needed for a given precision at a certain confidence level are calculated and presented. This calculation is very important as state departments of transportation are required to report faulting every 0.1 mi to the Federal Highway Administration as required by the 2015 FAST Act. On average, twice the number of measurements are needed on jointed reinforced concrete pavements (JRCP) to achieve the same confidence and precision as on jointed plain concrete pavements (JPCP). For example, a sample size of 13 is needed to achieve a 95% confidence interval with a precision of 1.0 mm for average faulting of JPCP, while 26 measurements are required for JRCP ones. Average faulting was found to correlate with several climatic, structural, and traffic variables, while no significant difference was found between edge and outer wheelpath measurements. The application of Portland cement concrete overlay and the use of dowel bars (rather than aggregate interlock) are found to significantly reduce faulting. Older sections located on higher functional classes, and in regions of high precipitation or where the daily temperature change is larger, tend to have higher faulting, and might require larger samples sizes as compared with the rest when faulting surveys are to be conducted.


2020 ◽  
Author(s):  
Adrián López Martín ◽  
Mohamed Mounir ◽  
Irmtraud M Meyer

Abstract RNA structure formation in vivo happens co-transcriptionally while the transcript is being made. The corresponding co-transcriptional folding pathway typically involves transient RNA structure features that are not part of the final, functional RNA structure. These transient features can play important functional roles of their own and also influence the formation of the final RNA structure in vivo. We here present CoBold, a computational method for identifying different functional classes of transient RNA structure features that can either aid or hinder the formation of a known reference RNA structure. Our method takes as input either a single RNA or a corresponding multiple-sequence alignment as well as a known reference RNA secondary structure and identifies different classes of transient RNA structure features that could aid or prevent the formation of the given RNA structure. We make CoBold available via a web-server which includes dedicated data visualisation.


2006 ◽  
Vol 66 (4) ◽  
pp. 903-911 ◽  
Author(s):  
Jonathan J. Ellis ◽  
Mark Broom ◽  
Susan Jones

Dermatology ◽  
1958 ◽  
Vol 116 (6) ◽  
pp. 419-426 ◽  
Author(s):  
Frederick Reiss
Keyword(s):  

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