scholarly journals The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains

1999 ◽  
Vol 27 (14) ◽  
pp. 2889-2897 ◽  
Author(s):  
T. Lee
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Transcriptional Activation ◽  
Wilms Tumor ◽  
Suppressor Gene ◽  
Activation Domains ◽  
Functional Classes ◽  
Transcriptional Activation Domains

Wt1-expressing progenitors contribute to multiple tissues in the developing lung

2013 ◽  
Vol 305 (4) ◽  
pp. L322-L332 ◽  
Author(s):  
Elena Cano ◽  
Rita Carmona ◽  
Ramón Muñoz-Chápuli
Keyword(s):  
Smooth Muscle ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Fluorescent Protein ◽  
Wilms Tumor ◽  
Yellow Fluorescent Protein ◽  
Suppressor Gene ◽  
Differentiation Potential ◽  
Mesenchymal Transition ◽  
Lung Morphogenesis

Lungs develop from paired endodermal outgrowths surrounded by a mesodermal mesenchyme. Part of this mesenchyme arises from epithelial-mesenchymal transition of the mesothelium that lines the pulmonary buds. Previous studies have shown that this mesothelium-derived mesenchyme contributes to the smooth muscle of the pulmonary vessels, but its significance for lung morphogenesis and its developmental fate are still little known. We have studied this issue using the transgenic mouse model mWt1/IRES/GFP-Cre (Wt1cre) crossed with the Rosa26R-EYFP reporter mouse. In the developing lungs, Wt1, the Wilms' tumor suppressor gene, is specifically expressed in the embryonic mesothelium. In the embryos obtained from the crossbreeding, the Wt1-expressing cell lineage produces the yellow fluorescent protein (YFP), allowing for colocalization with differentiation markers. Wt1cre-YFP cells were very abundant from the origin of the lung buds to postnatal stages, contributing significantly to pulmonary endothelial and smooth muscle cells, bronchial musculature, tracheal and bronchial cartilage, as well as CD34+ fibroblast-like interstitial cells. Thus Wt1cre-YFP mesenchymal cells show the very same differentiation potential as the splanchnopleural mesenchyme surrounding the lung buds. FSP1+ fibroblast-like cells were always YFP−; they expressed the common leukocyte antigen CD45 and were apparently recruited from circulating progenitors. We have also found defects in pulmonary development in Wt1−/− embryos, which showed abnormally fused lung lobes, round-shaped and reduced pleural cavities, and diaphragmatic hernia. Our results suggest a novel role for the embryonic mesothelium-derived cells in lung morphogenesis and involve the Wilms' tumor suppressor gene in the development of this organ.

Analysis of the 11p13 Wilms' Tumor Suppressor Gene (WTI) in Ovarian Tumors

1993 ◽  
Vol 11 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Wendy Bruening ◽  
Philippe Gros ◽  
Takaaki Sato ◽  
Jerry Stanimir ◽  
Yusuke Nakamura ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Wilms Tumor ◽  
Suppressor Gene ◽  
Ovarian Tumors

scholarly journals Cloning and Characterization of Two Promoters for the HumanHSAL2Gene and Their Transcriptional Repression by the Wilms Tumor Suppressor Gene Product

2001 ◽  
Vol 276 (51) ◽  
pp. 48223-48230 ◽  
Author(s):  
Yupo Ma ◽  
Dawei Li ◽  
Li Chai ◽  
Andrea M. Luciani ◽  
Dwayne Ford ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Product ◽  
Transcriptional Repression ◽  
Wilms Tumor ◽  
Suppressor Gene ◽  
Tumor Suppressor Gene Product

scholarly journals Regulated Expression and Potential Roles of p53 and Wilms’ Tumor Suppressor Gene (WT1) during Follicular Development in the Human Ovary1

2000 ◽  
Vol 85 (1) ◽  
pp. 449-459 ◽  
Author(s):  
Antonis Makrigiannakis ◽  
Kunjata Amin ◽  
George Coukos ◽  
Jonathan L. Tilly ◽  
Christos Coutifaris
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Wilms Tumor ◽  
Follicular Development ◽  
Suppressor Gene ◽  
Regulated Expression

Responsiveness of chemotherapy based on the histological type and Wilms' tumor suppressor gene mutation in bilateral Wilms' tumor

2003 ◽  
Vol 53 (4) ◽  
pp. 214-220 ◽  
Author(s):  
Rie Shibata ◽  
Ayako Takata ◽  
Akinori Hashiguchi ◽  
Akihiro Umezawa ◽  
Taketo Yamada ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Mutation ◽  
Wilms Tumor ◽  
Suppressor Gene ◽  
Histological Type ◽  
Bilateral Wilms Tumor
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