Human Epidemiological Evidence on the Nutritional Prevention of Cancer

2021 ◽  
pp. 83-100
Author(s):  
David J. Hunter ◽  
Walter C. Willett
Keyword(s):  
Epidemiological Evidence ◽  
Prevention Of Cancer

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

Benign paroxysmal vertigo and migraine in children: epidemiological evidence

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
S Karagiannopoulou ◽  
E Pavlidou ◽  
M Tzitiridou ◽  
C Panteliadis
Keyword(s):  
Epidemiological Evidence

Our Most Troubling Madness

2016 ◽  
Keyword(s):  
Social Defeat ◽  
Social World ◽  
Epidemiological Evidence ◽  
The West ◽  
Social Settings ◽  
The Social ◽  
Brain Alteration ◽  
Benign Course ◽  
Cultural Features ◽  
The Way

This book examines the way schizophrenia is shaped by its social context: how life is lived with this madness in different settings, and what it is about those settings that alters the course of the illness, its outcome, and even the structure of its symptoms. Until recently, schizophrenia was perhaps our best example—our poster child—for the “bio-bio-bio” model of psychiatric illness: genetic cause, brain alteration, pharmacologic treatment. We now have direct epidemiological evidence that people are more likely to fall ill with schizophrenia in some social settings than in others, and more likely to recover in some social settings than in others. Something about the social world gets under the skin. This book presents twelve case studies written by psychiatric anthropologists that help to illustrate some of the variability in the social experience of schizophrenia and that illustrate the main hypotheses about the different experience of schizophrenia in the west and outside the west--and in particular, why schizophrenia seems to have a more benign course and outcome in India. We argue that above all it is the experience of “social defeat” that increases the risk and burden of schizophrenia, and that opportunities for social defeat are more abundant in the modern west. There is a new role for anthropology in the science of schizophrenia. Psychiatric science has learned—epidemiologically, empirically, quantitatively—that our social world makes a difference. But the highly structured, specific-variable analytic methods of standard psychiatric science cannot tell us what it is about culture that has that impact. The careful observation enabled by rich ethnography allows us to see in more detail what kinds of social and cultural features may make a difference to a life lived with schizophrenia. And if we understand culture’s impact more deeply, we believe that we may improve the way we reach out to help those who struggle with our most troubling madness.

The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers

2020 ◽  
Vol 27 (38) ◽  
pp. 6536-6547 ◽  
Author(s):  
Yi-Hau Chen ◽  
Hsiuying Wang
Keyword(s):  
Phylogenetic Analysis ◽  
Major Depression ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Research Work ◽  
Epidemiological Evidence ◽  
The Relationship ◽  
Global Population ◽  
Shed Light

A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.

Recent Patents on Anti-Cancer Potential of Helenalin

2020 ◽  
Vol 15 (2) ◽  
pp. 132-142
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Synergistic Effects ◽  
Therapeutic Interventions ◽  
Active Constituent ◽  
Scientific Impact ◽  
Isolation Techniques ◽  
Anti Cancer ◽  
Prevention Of Cancer ◽  
Synthetic Derivatives

Background: Arnica montana, containing helenalin as its principal active constituent, is the most widely used plant to treat various ailments. Recent studies indicate that Arnica and helenalin provide significant health benefits, including anti-inflammatory, neuroprotective, antioxidant, cholesterol-lowering, immunomodulatory, and most important, anti-cancer properties. Objective: The objective of the present study is to overview the recent patents of Arnica and its principal constituent helenalin, including new methods of isolation, and their use in the prevention of cancer and other ailments. Methods: Current prose and patents emphasizing the anti-cancer potential of helenalin and Arnica, incorporated as anti-inflammary agents in anti-cancer preparations, have been identified and reviewed with particular emphasis on their scientific impact and novelty. Results: Helenalin has shown its anti-cancer potential to treat multiple types of tumors, both in vitro and in vivo. It has also portrayed synergistic effects when given in combination with other anti- cancer drugs or natural compounds. New purification/isolation techniques are also developing with novel helenalin formulations and its synthetic derivatives have been developed to increase its solubility and bioavailability. Conclusion: The promising anti-cancer potential of helenalin in various preclinical studies may open new avenues for therapeutic interventions in different tumors. Thus clinical trials validating its tumor suppressing and chemopreventive activities, particularly in conjunction with standard therapies, are immediately required.

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