Thin-Layer Chromatographic Screening and Gas Chromatographic/Mass Spectrometric Confirmation in the Analysis of Abused Drugs

2021 ◽  
pp. 221-265
Author(s):  
Pirjo Lillsunde ◽  
Taimi Korte
Keyword(s):  
Thin Layer ◽  
Mass Spectrometric ◽  
Abused Drugs ◽  
Chromatographic Mass

Detection of pentazocine and tripelennamine in urine.

1981 ◽  
Vol 27 (1) ◽  
pp. 10-13 ◽  
Author(s):  
R W Reid ◽  
C M Gerbeck
Keyword(s):  
Gas Chromatography ◽  
Drug Abuse ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Chemical Ionization ◽  
Mass Spectrometric ◽  
Routine Screening ◽  
Ionization Mode ◽  
Layer Chromatography ◽  
Chromatographic Mass

Abstract Pentazocine and tripelennamine can be identified in urine as a part of routine screening for drug abuse. Pentazocine, pentazocine hydrate, and tripelennamine can be detected by thin-layer chromatography of chloroform/isopropanol extracts of heat- and acid-hydrolyzed urine. Gas chromatography is used for confirmation. Gas chromatographic/mass spectrometric studies (chemical ionization mode) show that such extracts contain major molecular (M+) ions of m/e 256, 286, and 304, indicating the presence of tripelennamine, pentazocine, and pentazocine hydrate, respectively.

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