Randomization, Stratification, and Outcome-Adaptive Allocation

Author(s):  
Oleksandr Sverdlov ◽  
Yevgen Ryeznik
Keyword(s):  
2006 ◽  
Vol 12 (1) ◽  
pp. 79-90
Author(s):  
Moncef Elaoud ◽  
Bechir Hamdaoui ◽  
Parameswaran Ramanathan
Keyword(s):  

PEDIATRICS ◽  
1985 ◽  
Vol 76 (5) ◽  
pp. 849-851
Author(s):  
JAMES H. WARE ◽  
MICHAEL F. EPSTEIN

Bartlett et al,1 in last month's issue of Pediatrics, report the results of an innovative clinical trial of extracorporeal membrane oxygenation (ECMO) in the treatment of infants with respiratory failure. The authors report that, prior to introducing ECMO, infants meeting their criteria for respiratory failure had an 80% or greater chance of early death despite optimal conventional care. Because continued randomization in a 50-50 fashion would have presented ethical problems if early results were very favorable to ECMO, the investigators employed an "adaptive allocation" scheme, that is, a design that modified the treatment assignment probabilities according to results for previously randomized patients. The design chosen was a "randomized play-the-winner" design.2


2021 ◽  
Author(s):  
Vincent Graber ◽  
Eugenio Schuster

Abstract ITER will be the first tokamak to sustain a fusion-producing, or burning, plasma. If the plasma temperature were to inadvertently rise in this burning regime, the positive correlation between temperature and the fusion reaction rate would establish a destabilizing positive feedback loop. Careful regulation of the plasma’s temperature and density, or burn control, is required to prevent these potentially reactor-damaging thermal excursions, neutralize disturbances and improve performance. In this work, a Lyapunov-based burn controller is designed using a full zero-dimensional nonlinear model. An adaptive estimator manages destabilizing uncertainties in the plasma confinement properties and the particle recycling conditions (caused by plasma-wall interactions). The controller regulates the plasma density with requests for deuterium and tritium particle injections. In ITER-like plasmas, the fusion-born alpha particles will primarily heat the plasma electrons, resulting in different electron and ion temperatures in the core. By considering separate response models for the electron and ion energies, the proposed controller can independently regulate the electron and ion temperatures by requesting that different amounts of auxiliary power be delivered to the electrons and ions. These two commands for a specific control effort (electron and ion heating) are sent to an actuator allocation module that optimally maps them to the heating actuators available to ITER: an electron cyclotron heating system (20 MW), an ion cyclotron heating system (20 MW), and two neutral beam injectors (16.5 MW each). Two different actuator allocators are presented in this work. The first actuator allocator finds the optimal mapping by solving a convex quadratic program that includes actuator saturation and rate limits. It is nonadaptive and assumes that the mapping between the commanded control efforts and the allocated actuators (i.e., the effector model) contains no uncertainties. The second actuator allocation module has an adaptive estimator to handle uncertainties in the effector model. This uncertainty includes actuator efficiencies, the fractions of neutral beam heating that are deposited into the plasma electrons and ions, and the tritium concentration of the fueling pellets. Furthermore, the adaptive allocator considers actuator dynamics (actuation lag) that contain uncertainty. This adaptive allocation algorithm is more computationally efficient than the aforementioned nonadaptive allocator because it is computed using dynamic update laws so that finding the solution to a static optimization problem is not required at every time step. A simulation study assesses the performance of the proposed adaptive burn controller augmented with each of the actuator allocation modules.


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