The effectiveness of a typical helicopter particle separation system has been numerically assessed at practical operating conditions and sand environments for various scenarios. The particle separation mechanism and its limitation are revealed by the flow characteristics and particle trajectories in the flow-field. The separation-by-inertia concept is effective for removing large particles, but problematic for small particles of diameter (d) ≤ 36μm. The particle size, shape factor, and rebound characteristics exert substantial effects on particle scavenge efficiency. On the other hand, the effects of gravity, particle inlet velocity, inlet mass distribution, and engine operating conditions on scavenge efficiency are minor or limited for the configurations and operating conditions considered in the present study. In addition, a few suggestions for further investigation on engine particle separation systems are included.