Cavitation threshold pressure of focused ultrasound observed with sonochemiluminescence

Spatial distribution of sonochemiluminescence (SCL) from an argon-saturated luminol solution was measured in a focused sound field at 1 MHz in a standing-wave configuration. The SCL distribution was confined to pre-focal region at acoustic powers lower than 0.9 W, and was not located at the focus but at a few mm pre-focal side at a threshold for SCL inception. The threshold pressure amplitude for SCL inception was 3.6 atm at the focus, which value was obtained with a background-oriented schlieren method. The method is based on the broadening of multiple slits due to an optical deflection caused by ultrasound, and the broadening width measured provides an acoustic pressure amplitude. A qualitative image of the focused sound field was also obtained.

The Impact of Surface Drug Distribution on the Acoustic Behavior of DOX-Loaded Microbubbles

Previous studies have reported substantial improvement of microbubble (MB)-mediated drug delivery with ultrasound when drugs are loaded onto the MB shell compared with a physical mixture. However, drug loading may affect shell properties that determine the acoustic responsiveness of MBs, producing unpredictable outcomes. The aim of this study is to reveal how the surface loaded drug (doxorubicin, DOX) affects the acoustic properties of MBs. A suitable formulation of MBs for DOX loading was first identified by regulating the proportion of two lipid materials (1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phospho-rac-glycerol sodium salt (DSPG)) with distinct electrostatic properties. We found that the DOX loading capacity of MBs was determined by the proportion of DSPG, since there was an electrostatic interaction with DOX. The DOX payload reduced the lipid fluidity of MBs, although this effect was dependent on the spatial uniformity of DOX on the MB shell surface. Loading DOX onto MBs enhanced acoustic stability 1.5-fold, decreased the resonance frequency from 12–14 MHz to 5–7 MHz, and reduced stable cavitation dose by 1.5-fold, but did not affect the stable cavitation threshold (300 kPa). Our study demonstrated that the DOX reduces lipid fluidity and decreases the elasticity of the MB shell, thereby influencing the acoustic properties of MBs.

Cavitation Effect in Ultrasonic-Assisted Electrolytic In-Process Dressing Grinding of Nanocomposite Ceramics

Ultrasonic-assisted electrolytic in-process dressing (UA-ELID) grinding is a promising technology that uses a metal-bonded diamond grinding wheel to achieve a mirror surface finish on hard and brittle materials. In this paper, the UA-ELID grinding was applied to nanocomposite ceramic for investigating the cavitation effect on the processing performance. Firstly, the ultrasonic cavitation theory was utilized to define the cavitation threshold, collapse of cavitation bubbles, and variation of their radii. Next, the online monitoring system was designed to observe the ultrasonic cavitation under different ultrasonic amplitude for the actual UA-ELID grinding test. A strong effect of ultrasonic cavitation on the grinding wheel surface and the formed oxide film was experimentally proved. Besides, under the action of ultrasonic vibration, the dressing effect of the grinding wheel was improved, and the sharpness of grain increased by 43.2%, and the grain distribution was dramatically changed with the increase of ultrasonic amplitude. Compared with the conventional ELID (C-ELID) grinding, the average protrusion height increased by 14.2%, while the average grain spacing dropped by 21.2%. The UA-ELID grinding reduced the workpiece surface roughness Rz and Ra by 54.2% and 46.5%, respectively, and increased the surface residual compressive stress by 44.5%. The surface morphology observation revealed a change in the material removal mechanism and improvement of the surface quality by ultrasonic cavitation effect. These findings are considered instrumental in theoretical and experimental substantiation of the optimal UA-ELID grinding parameters for the processing of nanocomposite ceramics.

Cavitation Dynamics and Inertial Cavitation Threshold of Lipid Coated Microbubbles in Viscoelastic Media with Bubble–Bubble Interactions

Encapsulated microbubbles combined with ultrasound have been widely utilized in various biomedical applications; however, the bubble dynamics in viscoelastic medium have not been completely understood. It involves complex interactions of coated microbubbles with ultrasound, nearby microbubbles and surrounding medium. Here, a comprehensive model capable of simulating the complex bubble dynamics was developed via taking the nonlinear viscoelastic behaviors of the shells, the bubble–bubble interactions and the viscoelasticity of the surrounding medium into account simultaneously. For two interacting lipid-coated bubbles with different initial radii in viscoelastic media, it exemplified that the encapsulating shell, the inter-bubble interactions and the medium viscoelasticity would noticeably suppress bubble oscillations. The inter-bubble interactions exerted a much stronger suppressing effect on the small bubble within the parameters examined in this paper, which might result from a larger radiated pressure acting on the small bubble due to the inter-bubble interactions. The lipid shells make the microbubbles exhibit two typical asymmetric dynamic behaviors (i.e., compression or expansion dominated oscillations), which are determined by the initial surface tension of the bubbles. Accordingly, the inertial cavitation threshold decreases as the initial surface tension increases, but increases as the shell elasticity and viscosity increases. Moreover, with the distance between bubbles decreasing and/or the initial radius of the large bubble increasing, the oscillations of the small bubble decrease and the inertial cavitation threshold increases gradually due to the stronger suppression effects caused by the enhanced bubble–bubble interactions. Additionally, increasing the elasticity and/or viscosity of the surrounding medium would also dampen bubble oscillations and result in a significant increase in the inertial cavitation threshold. This study may contribute to both encapsulated microbubble-associated ultrasound diagnostic and emerging therapeutic applications.

Bubbles in superfluid helium containing six and eight electrons: Soft, quantum nanomaterial

The role of quantum fluctuations in the self-assembly of soft materials is relatively unexplored, which could be important in the development of next-generation quantum materials. Here, we report two species of nanometer-sized bubbles in liquid helium-4 that contain six and eight electrons, forming a versatile, platform to study self-assembly at the intersection of classical and quantum worlds. These objects are formed through subtle interplay of the short-range electron-helium repulsion and easy deformability of the bulk liquid. We identify these nanometric bubbles in superfluid helium using cavitation threshold spectroscopy, visualize their decoration of quantized vortex lines, and study their creation through multiple methods. The objects were found to be stable for at least 15 milliseconds at 1.5 kelvin and can therefore allow fundamental studies of few-body quantum interactions under soft confinements.

An Analysis of Acoustic Cavitation Thresholds of Water Based on the Incubation Time Criterion Approach

Researchers are still working on the development of models that facilitate the accurate estimation of acoustic cavitation threshold. In this paper, we have analyzed the possibility of using the incubation time criterion to calculate the threshold of the onset of acoustic cavitation depending on the ultrasound frequency, hydrostatic pressure, and temperature of a liquid. This criterion has been successfully used by earlier studies to calculate the dynamic strength of solids and has recently been proposed in an adapted version for calculating the cavitation threshold. The analysis is carried out for various experimental data for water presented in the literature. Although the criterion assumes the use of macroparameters of a liquid, we also considered the possibility of taking into account the size of cavitation nuclei and its influence on the calculation result. We compared the results of cavitation threshold calculations done using the incubation time criterion of cavitation and the classical nucleation theory. Our results showed that the incubation time criterion more qualitatively models the results of experiments using only three parameters of the liquid. We then discussed a possible relationship between the parameters of the two approaches. The results of our study showed that the criterion under consideration has a good potential and can be conveniently used for applications where there are special requirements for ultrasound parameters, maximum negative pressure, and liquid temperature.