Recent advances in the exploratory analysis of interregional flows in space and time

1997 ◽  
pp. 93-106
Science ◽  
2020 ◽  
Vol 370 (6520) ◽  
pp. eaaz3041 ◽  
Author(s):  
Emiliano Brini ◽  
Carlos Simmerling ◽  
Ken Dill

Every protein has a story—how it folds, what it binds, its biological actions, and how it misbehaves in aging or disease. Stories are often inferred from a protein’s shape (i.e., its structure). But increasingly, stories are told using computational molecular physics (CMP). CMP is rooted in the principled physics of driving forces and reveals granular detail of conformational populations in space and time. Recent advances are accessing longer time scales, larger actions, and blind testing, enabling more of biology’s stories to be told in the language of atomistic physics.


2021 ◽  
Vol 66 (1) ◽  
pp. 225-241 ◽  
Author(s):  
Dimitar Dimitrov ◽  
Gustavo Hormiga

Spiders (Araneae) make up a remarkably diverse lineage of predators that have successfully colonized most terrestrial ecosystems. All spiders produce silk, and many species use it to build capture webs with an extraordinary diversity of forms. Spider diversity is distributed in a highly uneven fashion across lineages. This strong imbalance in species richness has led to several causal hypotheses, such as codiversification with insects, key innovations in silk structure and web architecture, and loss of foraging webs. Recent advances in spider phylogenetics have allowed testing of some of these hypotheses, but results are often contradictory, highlighting the need to consider additional drivers of spider diversification. The spatial and historical patterns of diversity and diversification remain contentious. Comparative analyses of spider diversification will advance only if we continue to make progress with studies of species diversity, distribution, and phenotypic traits, together with finer-scale phylogenies and genomic data.


2021 ◽  
pp. 002234332110200
Author(s):  
Jaclyn Johnson

Military mutinies are critical to scholars’ collective understanding of civil–military relations. This article introduces a new dataset that systematically codes mutinies across all regions and conducts an exploratory analysis of these new data. The primary contribution made here is the introduction of a new dataset that provides scholars with a sample of mutinies across region, space, and time. The new Military Mutinies and Defections Database (MMDD) codes events of military indiscipline from 1945 to 2017. This dataset uses geocoding techniques that will enable scholars to explore the spatial patterns and diffusion associated with mutinies. The second contribution is the preliminary exploration of these new data. Of note, I demonstrate that over one-third of all mutinies are violent, 6% of mutinies are associated with civilian deaths, and anocracies are more likely to experience mutinies than democratic or autocratic counterparts. MMDD provides investigators with an exciting new tool to explore dimensions of military disloyalty.


2017 ◽  
Vol 91 (18) ◽  
Author(s):  
Pierre M. Jean Beltran ◽  
Katelyn C. Cook ◽  
Ileana M. Cristea

ABSTRACT Viral replication in eukaryotes is a process inherently organized in both space and time. Viral components target subcellular organelles to access host machineries required for replication and spread. Diverse viruses are known to alter organelle shape, composition, function, and dynamics as part of their replication cycles. Here, we highlight recent advances in microscopy and proteomic methods that have helped and will continue to help define mechanisms used by viruses to exploit host proteome organization.


1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.


2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.


2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.


1950 ◽  
Vol 34 (5) ◽  
pp. 1363-1380
Author(s):  
Theodore L. Badger ◽  
William E. Patton

1990 ◽  
Vol 23 (2) ◽  
pp. 251-270
Author(s):  
Martin P. Sandler, MD ◽  
James A. Patton ◽  
Robert H. Ossoff

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