Background:
Rifampicin (RIF), also known as rifampin, a bactericidal antibiotic having broad antibacterial activity against various gram-positive and gram-negative bacteria act by inhibiting DNA dependent RNA polymerase. RIF
has been administered in different dosage forms like tablets, capsules, injections, oral suspension, powder etc. for the
treatment of several types of bacterial infections, including tuberculosis, Mycobacterium avium complex, leprosy and Legionnaires’ disease.
Introduction:
To ensure the quality, efficacy, safety and effectiveness of RIF drug product, effective
and reliable analytical methods are utmost important. To quantify RIF for quality control or pharmacokinetic purposes, alternative analytical methods have been developed along with the official compendial methods. Method: In this review paper, an extensive literature survey was done to gather information on various analytical instrumental methods used so far
for RIF.
Result:
These methods were high-performance liquid chromatography (42%), hyphenated techniques (18%),
spectroscopy (15%), high-performance thin-layer chromatography or thin-layer chromatography (7%) and miscellaneous
(18%). Conclusion: All these methods were selective and specific for the RIF analysis.
