ASSOCIATION OF RACE, APGAR SCORE AT FIVE MINUTES AND FORMULA FEEDING WITH RETINOPATHY OF PREMATURITY (ROP) AMONG VERY LOW BIRTH WEIGHT (VLBW) INFANTS.† 1181

Abstract Background Neonatal hypothermia, defined as a temperature < 36.5°C, is a major contributor to neonatal mortality and morbidity. Hypothermia in preterm infants remains a challenge in the neonatal intensive care unit (NICU) for many reasons.Objective To investigate the incidence of admission hypothermia (AH) in very low-birth weight (VLBW) infants in multiple NICUs in Shandong Province, China, and to provide clinical evidence for the implementation of quality improvement practices to reduce the incidence of AH in NICU.Methods This retrospective, observational study was carried out over a period of 12 months, from January 1, 2018 to December 31, 2018. The correlations between hypothermia preventive measures and the incidence of AH were analysed by descriptive statistical methods and a Spearman analysis. The associations between AH and maternal and neonatal variables were tested with bivariate analyses, followed by stepwise logistic regression. P <0.05 was considered statistically significant.Results A total of 1639 in-born infants who were born at a weight less than 1500 g were enrolled in the study on their day of birth. Among them, 1295 VLBW infants fulfilled the inclusion criteria. The incidence of AH was 87.9% in VLBW infants among the 28 NICUs. We investigated whether team training and education, such as monthly chart reporting on hypothermia in preterm infants on admission to the NICU, which was associated with 10.7% of all the cases, could decrease the rate of AH. Indeed, transport with a heated transport incubator was associated with 9.3% of the cases. here was a negative correlation between the incidence of AH and the number of quality improvement measures implemented to prevent hypothermia (r= -0.242, p <0.05). A low birth weight, intubation in the delivery room , and a low 5-min Apgar score were significantly associated with AH. Conclusion: The incidence of AH was high. There was a negative correlation between the incidence of AH and the number of quality improvement measures implemented to prevent hypothermia. It is important to monitor for AH in newborns who have a low birth weight, who have a low Apgar score at 5 min and who require intubation in the delivery room.

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PP-185. Genome wide microarray analysis in very low birth weight (VLBW) infants with retinopathy of prematurity (ROP) — Preliminary results

Early Human Development ◽

10.1016/j.earlhumdev.2010.09.240 ◽

2010 ◽

Vol 86 ◽

pp. S91-S92

Author(s):

Jacek Jozef Pietrzyk ◽

Przemko Kwinta ◽

Anna Madetko-Talowska ◽

Miroslaw Bik-Multanowski ◽

Ola D. Saugstad

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Microarray Analysis ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Vlbw Infants ◽

Preliminary Results ◽

Genome Wide

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280 Antenatal Betamethasone (ANB) May Prevent Severe Retinopathy of Prematurity (ROP) in Very Low Birth Weight (VLBW) Infants

Pediatric Research ◽

10.1203/00006450-200508000-00309 ◽

2005 ◽

Vol 58 (2) ◽

pp. 402-402

Author(s):

C Papagaroufalis ◽

G Pollalis ◽

M Xanthou

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Vlbw Infants

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PO-0647 To Determine The Incidence, Risk Factors And Need For Surgery For Retinopathy Of Prematurity(rop) Among Very-low-birth-weight(vlbw) Infants Weighing <1500gms

Archives of Disease in Childhood ◽

10.1136/archdischild-2014-307384.1288 ◽

2014 ◽

Vol 99 (Suppl 2) ◽

pp. A465.3-A465 ◽

Cited By ~ 1

Author(s):

V Shah ◽

J Chiang ◽

S Chung ◽

Y Ling

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Vlbw Infants ◽

Incidence Risk

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EFFECT OF VITAMIN A (VA) SUPPLEMENTATION ON RETINOPATHY OF PREMATURITY (ROP) IN VERY LOW BIRTH WEIGHT (VLBW) INFANTS

Pediatric Research ◽

10.1203/00006450-199211000-00076 ◽

1992 ◽

Vol 32 (5) ◽

pp. 617-617

Author(s):

C Papagaroufalis ◽

G Spyropoulos ◽

E Stamocosta ◽

C H Megreli ◽

M Xanthou

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Vitamin A ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Vlbw Infants

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Arterial Catheters, Endothelin, and ROP

PEDIATRICS ◽

10.1542/peds.88.4.874a ◽

1991 ◽

Vol 88 (4) ◽

pp. 874-875

Author(s):

ITSURO YAMANOUCHI ◽

IKUKO IGARASHI

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Retinopathy Of Prematurity ◽

Very Low Birth Weight ◽

Medical Center ◽

International Classification ◽

National Hospital ◽

Vlbw Infants

To the Editor.— During the 15 years from 1976 to 1990, a total of 615 cases of very low birth weight (VLBW) infants weighing between 500 and 1500 g were treated at the Okayama National Hospital Children's Medical Center. 497 of them survived. There were 121 cases of retinopathy of prematurity (ROP), 15 of which were treated with cryocoagulation. The Table shows the classification of the VLBW cases according to birth weight and International Classification of ROP.

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Association between admission hypothermia and outcomes in very low birth weight infants in China: a multicentre prospective study

10.21203/rs.3.rs-16397/v1 ◽

2020 ◽

Author(s):

Yong-hui Yu ◽

Li Wang ◽

Qing-hua Lu ◽

Li-ling Wang ◽

Xiao-yang Huang ◽

...

Keyword(s):

Birth Weight ◽

Caesarean Section ◽

Low Birth Weight ◽

Apgar Score ◽

Very Low Birth Weight ◽

Mild Hypothermia ◽

World Health ◽

Vlbw Infants ◽

Severe Hypothermia ◽

Hypothermia Group

Abstract Background The objective of this study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants in multiple neonatal intensive care units (NICUs) in China. Methods Since January 1, 2018, a neonatal homogeneous cooperative research platform has been established. The platform collects clinical data in a prospective manner on preterm infants with birth weights (BWs)<1500 g and gestational ages (GAs)<34 weeks born in 28 NICUs in Shandong Province. These infants were divided into normothermia, mild or moderate/severe hypothermia groups according to the World Health Organization (WHO) classifications of hypothermia. Associations between outcomes and hypothermia were tested in a bivariate analysis, followed by a stepwise logistic regression analysis. Results A total of 1247 VLBW infants were included in this analysis, of which 1100 infants (88.2%) were included in the hypothermia group, 554 infants (44.4%) in the mild hypothermia group and 546 infants (43.8%) in the moderate/severe hypothermia group. Small for gestational age (SGA), caesarean section, a low Apgar score at 5 min and intubation in the delivery room (DR) were related to admission hypothermia (AH). Mortality was the lowest when their admission temperature was 36.5~37.5°C, and after adjustment for maternal and infant characteristics, mortality was significantly associated with AH. Compared with infants with normothermia (36.5~37.5°C), the adjusted ORs of all deaths increased to 4.148 (95% CI 1.505-11.437) and 1.806 (95% CI 0.651-5.009) for infants with moderate/severe hypothermia and mild hypothermia, respectively. AH was also associated with a high likelihood of respiratory distress syndrome (RDS), intraventricular haemorrhage (IVH), and late-onset neonatal sepsis (LOS). Conclusions AH is still very high in VLBW infants in NICUs in China. SGA, caesarean section, antenatal steroid use, a low Apgar score at 5 min and intubation in the DR were associated with increased odds of hypothermia. Moderate/severe hypothermia was associated with mortality and poor outcomes, such as RDS, IVH, LOS, etc.

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