scholarly journals Long-Term Neuroprotective Effect of Postischemic Hypothermia in a Neonatal Rat Model of Severe Hypoxic Ischemic Encephalopathy: A Comparative Study on the Duration and Depth of Hypothermia

2010 ◽  
Vol 68 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Byong Sop Lee ◽  
Chul-Woong Woo ◽  
Sang-Tae Kim ◽  
Ki-Soo Kim
Keyword(s):  
Comparative Study ◽  
Rat Model ◽  
Neuroprotective Effect ◽  
Neonatal Rat ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy ◽  
Neonatal Rat Model

Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy

2017 ◽  
Vol 1659 ◽  
pp. 81-87 ◽  
Author(s):  
Bulent Goren ◽  
Aysen Cakir ◽  
Busra Ocalan ◽  
Sema Serter Kocoglu ◽  
Tulin Alkan ◽  
...  
Keyword(s):  
Rat Model ◽  
Neonatal Rat ◽  
Hypoxic Ischemic Encephalopathy ◽  
Cognitive Effects ◽  
Ischemic Encephalopathy ◽  
Neonatal Rat Model

scholarly journals Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy

2020 ◽  
Vol 8 ◽  
Author(s):  
Bhavna Gupta ◽  
Mary G. Hornick ◽  
Seema Briyal ◽  
Ramona Donovan ◽  
Preetha Prazad ◽  
...  
Keyword(s):  
Rat Model ◽  
Immunomodulatory Effect ◽  
Neonatal Rat ◽  
Hypoxic Ischemic Encephalopathy ◽  
Cb2 Agonist ◽  
Ischemic Encephalopathy ◽  
Neonatal Rat Model

scholarly journals hUC-MSCs Exert a Neuroprotective Effect via Anti-apoptotic Mechanisms in a Neonatal HIE Rat Model

2019 ◽  
Vol 28 (12) ◽  
pp. 1552-1559 ◽  
Author(s):  
Jianwei Xu ◽  
Zhanhui Feng ◽  
Xianyao Wang ◽  
Ying Xiong ◽  
Lan Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Rat Model ◽  
Caspase 3 ◽  
Neuroprotective Effect ◽  
Hypoxic Ischemic Encephalopathy ◽  
Human Umbilical Cord ◽  
Motor Functions ◽  
Ischemic Encephalopathy

In this study, we investigated how human umbilical cord mesenchymal stem cells exerted a neuroprotective effect via antiapoptotic mechanisms in a neonatal hypoxic-ischemic encephalopathy rat model. A total of 78 10-day old (P10) rats were used. After human umbilical cord mesenchymal stem cells were collected from human umbilical cords and amplified in culture, they were administered to rat subjects 1 h after induced hypoxic-ischemic encephalopathy treatment. The short-term (48 h) and long-term (28 day) outcomes were evaluated after human umbilical cord mesenchymal stem cells treatment using neurobehavioral function assessment. Triphenyltetrazolium chloride monohydrate staining was performed at 48 h. Beclin-2 and caspase-3 levels were evaluated with Western blot and real time polymerase chain reaction at 48 h. Human umbilical cord mesenchymal stem cells were collected and administrated to hypoxic-ischemic encephalopathy pups by intracerebroventricular injection. Hypoxic-ischemic encephalopathy typically induced significant delay in development and caused impairment in both cognitive and motor functions in rat subjects. Human umbilical cord mesenchymal stem cells were shown to ameliorate hypoxic-ischemic encephalopathy-induced damage and improve both cognitive and motor functions. Although hypoxic-ischemic encephalopathy induced significant expression of caspase-3 and Beclin-2, human umbilical cord mesenchymal stem cells decreased the expression of both of them. Human umbilical cord mesenchymal stem cells may serve as a potential treatment to ameliorate brain injury in hypoxic-ischemic encephalopathy patients.

Neuroprotective effect of L-arginine in a neonatal rat model of hypoxic-ischemia

2019 ◽  
Vol 129 (11) ◽  
pp. 1139-1144 ◽  
Author(s):  
Ibrahim Hirfanoglu ◽  
Canan Turkyilmaz ◽  
Zafer Turkyilmaz ◽  
Esra Onal ◽  
Figen Soylemezoglu ◽  
...  
Keyword(s):  
Rat Model ◽  
Neuroprotective Effect ◽  
Neonatal Rat ◽  
Hypoxic Ischemia ◽  
Neonatal Rat Model

Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic–ischemic brain injury

2003 ◽  
Vol 25 (7) ◽  
pp. 494-498 ◽  
Author(s):  
Adem Aydin ◽  
Kursad Genc̨ ◽  
Mustafa Akhisaroglu ◽  
Kutsal Yorukoglu ◽  
Necati Gokmen ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuroprotective Effect ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model

scholarly journals Novel Neuroprotective Agents to Treat Neonatal Hypoxic-Ischemic Encephalopathy: Inter-Alpha Inhibitor Proteins

2020 ◽  
Vol 21 (23) ◽  
pp. 9193
Author(s):  
Liam M. Koehn ◽  
Xiaodi Chen ◽  
Aric F. Logsdon ◽  
Yow-Pin Lim ◽  
Barbara S. Stonestreet
Keyword(s):  
Brain Injury ◽  
Premature Infants ◽  
Time Window ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Neonatal Rat ◽  
Hypoxic Ischemic Encephalopathy ◽  
Limited Effectiveness ◽  
Ischemic Encephalopathy

Perinatal hypoxia-ischemia (HI) is a major cause of brain injury and mortality in neonates. Hypoxic-ischemic encephalopathy (HIE) predisposes infants to long-term cognitive deficits that influence their quality of life and place a large burden on society. The only approved treatment to protect the brain after HI is therapeutic hypothermia, which has limited effectiveness, a narrow therapeutic time window, and is not considered safe for treatment of premature infants. Alternative or adjunctive therapies are needed to improve outcomes of full-term and premature infants after exposure to HI. Inter-alpha inhibitor proteins (IAIPs) are immunomodulatory molecules that are proposed to limit the progression of neonatal inflammatory conditions, such as sepsis. Inflammation exacerbates neonatal HIE and suggests that IAIPs could attenuate HI-related brain injury and improve cognitive outcomes associated with HIE. Recent studies have shown that intraperitoneal treatment with IAIPs can decrease neuronal and non-neuronal cell death, attenuate glial responses and leukocyte invasion, and provide long-term behavioral benefits in neonatal rat models of HI-related brain injury. The present review summarizes these findings and outlines the remaining experimental analyses necessary to determine the clinical applicability of this promising neuroprotective treatment for neonatal HI-related brain injury.

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